Antidiabetic effects of extracts from Psidium guajava

Oh, Won Keun; Lee, Chul‐Ho; Lee, Myung Sun; Bae, Eun Young; Sohn, Cheon Bae; Oh, Hyuncheol; Kim, Bo Yeon; Ahn, Jong Seog

doi:10.1016/j.jep.2004.09.041

Cited by 168 publications

(97 citation statements)

References 19 publications

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“…The butanol-soluble fraction significantly decrease the number of lipid droplets. 66 Ethanolic extract of stem bark of P. guajava exhibited significant hypoglycaemic activity in alloxan-induced hyperglycaemic rats. 67 The aqueous leaf extract of P. guajava have the potential effect of inhibition of the alpha-glucosidase activity from the small intestinal mucosa of diabetic mouse.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Phytopharmacological overview of Psidium guajava Linn.

Anand¹,

Manikandan²,

Kumar³

et al. 2016

Phcogj

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Psidium guajava Linn. possesses useful medicinal benefits. It has been recognized as the medicinally essential phytoconstituents, such as phenolic, flavonoid and carotenoid. Numerous pharmacological investigation have confirmed that the ability of this plant is to exhibit antimicrobial, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, antioxidant and anticancer activities and it supports the traditional uses. This is a comprehensive of the phytoconstituents and pharmacological benefits.

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Section: Antidiabetic Activitymentioning

confidence: 99%

Phytopharmacological overview of Psidium guajava Linn.

Anand¹,

Manikandan²,

Kumar³

et al. 2016

Phcogj

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“…A great deal of research has shown and related its chemical composition and activities, based on the use of extracts prepared with organic toxic solvents (De Araújo et al, 2014;Thaipong et al, 2006), thus limiting its use in the health care industry. Also, the vast majority of the extracts studied were prepared from leaves and not from the hole fruit as suggested herein (Jaiarj et al, 1999;Lutterodt, Maleque, 1988, Oh et al, 2005.…”

Section: Introductionmentioning

confidence: 99%

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Chiari-Andréo

Trovatti

Marto

et al. 2017

Braz. J. Pharm. Sci.

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Guava (Psidium guajava L.) is a native fruit of the American tropics with commercial applications for its taste, flavor and aroma. Numerous pharmacological uses have been described for it, such as the antiseptic effect of its leaves, the use of the fresh fruit and tea from its leaves for the treatment of diarrhea, dysentery, diabetes mellitus, and others. However, considering its rich composition, the guava also is a potential source of antioxidants to be used in the development of new formulations for cosmetic and/or dermatological applications, the main focus of this research. Herein, we describe the study of the phytochemical composition and the antioxidant activity of a guava extract prepared with non-toxic solvents aiming its use at biological applications. High performance liquid chromatography and mass spectrometry were employed to identify the major components, while thermoanalytical measurements and hot stage microscopy were used to assess the chemical stability of guava fruit extract. The antioxidant activity was also evaluated assessing the SOD-like activity and ABTS free radical scavenger. The results show that the extract is a rich source of phenolic compounds, such as quercetin, kaempferol, schottenol, among many others. All of the components found in guava extract exhibit biological effects according to the literature data, mainly antioxidant properties. Uniterms

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“…For example, Park team [7] screened chemical database distributed by Interbioscreen containing 350000 compounds, identifying 9 novel PTP1B inhibitors in 2009. In 2005, study showed that the extracts from Psidium guajava could inhibit PTP1B and decrease the blood sugar in mice [8]. In 2011, Liu et al [9] screened 32 compounds of hypoglycemic components in Psidium guajava, obtaining 5 flavanoids and tannins compounds with PTP1B inhibitory effect.…”

Section: Introductionmentioning

confidence: 99%

Discovery and study of novel protein tyrosine phosphatase 1B inhibitors

Zhang¹,

Chen²,

Feng³

2017

AIP Conference Proceedings

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Abstract. Protein tyrosine phosphatase 1B (PTP1B) is considered to be a target for therapy of type diabetes and obesity. So it is of great significance to take advantage of a computer aided drug design protocol involving the structured-based virtual screening with docking simulations for fast searching small molecule PTP1B inhibitors. Based on optimized complex structure of PTP1B bound with specific inhibitor of IX1, structured-based virtual screening against a library of natural products containing 35308 molecules, which was constructed based on Traditional Chinese Medicine database@ Taiwan (TCM database@ Taiwan ), was conducted to determine the occurrence of PTP1B inhibitors using the Lubbock module and CDOCKER module from Discovery Studio 3.1 software package. The results were further filtered by predictive ADME simulation and predictive toxic simulation. As a result, 2 good drug-like molecules, namely parabenzoquinone compound 1 and Clavepictine analogue 2 were identified ultimately with the dock score of original inhibitor (IX1) and the receptor as a threshold. Binding model analyses revealed that these two candidate compounds have good interactions with PTP1B. The PTP1B inhibitory activity of compound 2 hasn't been reported before. The optimized compound 2 has higher scores and deserves further study.

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Antidiabetic effects of extracts from Psidium guajava

Cited by 168 publications

References 19 publications

Phytopharmacological overview of Psidium guajava Linn.

Phytopharmacological overview of Psidium guajava Linn.

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Discovery and study of novel protein tyrosine phosphatase 1B inhibitors

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