Antidiabetic effects ofEmbelia ribesextract in high fat diet and low dose streptozotocin-induced type 2 diabetic rats

Abstract

Embelia ribes is extensively used in the traditional Indian system of medicine for treatment of various disorders. We herein investigated the antidiabetic effects of E. ribes ethanolic extract in high fat diet (HFD) and low dose streptozotocin (STZ)-induced type 2 diabetes in Wistar rats. HFD-fed and low dose STZ (35 mg kg −1 , i.p)-induced diabetic rats were treated with E. ribes extract (100 and 200 mg kg −1 day −1 ) or metformin (180 mg kg −1 day −1 ) for 21 days while continuing on HFD. Antihyperglycemic effects of E. ribes extract were demonstrated by significant reduction (p < 0.01) in fasting blood glucose, hepatic glucose-6-phosphatase activity and increased glycogen content, whereas insulin sensitizing effects were seen during oral glucose tolerance testing. In addition, it significantly (p < 0.01) restored the elevated systolic and diastolic blood pressure, reduced hepatic fatty degeneration, oxidative changes and the reversal of circulating levels of serum lipids, lipase, insulin, leptin and adiponectin towards normal in diabetic rats. These findings demonstrated the antidiabetic potential of E. ribes extract in HFD-fed and low dose STZ-treated diabetic rats. This may be associated with strong antioxidant potential and restoration of the serum levels of leptin, adiponectin, insulin and lipids.

Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice

“…High glucose levels were stored in the liver and muscle tissue with the help of insulin using a glucose transporter. As a result, the hepatic glycogen content in the HFD/STZ-induced diabetic control group signifi cantly reduced (P<0.05) compared to the normal control group, which was indicative of tissue insulin resistance [Bhandari et al, 2013]. Treatment with MVR and glibenclamide would be able to restore glycogen content indicating tissue glucose uptake and hepatic glucose production [Moore et al, 2012].…”

Sansevieria roxburghiana Schult. & Schult. F. (Family: Asparagaceae) Attenuates Type 2 Diabetes and Its Associated Cardiomyopathy

“…Despite the presented literature revealed that β-cells have the ability to regenerate, however, controversies are still existing [52,53]. The partial destruction of β-cells by the small dose of streptozotocin to high fat fed rats has been claimed to induce T2D by lowering insulin secretion coupled with insulin resistance [23,54]. The significantly lower level of serum insulin in T2D control rats indicted the partial destruction of pancreatic β-cells.…”

A Review on Therapeutic Use of Vidanga (Embelia Ribes) for Pathological Consequences Associated With Obesity as Per Ayurvedic Classics

“…Administration of Embelia Ribes ethanolic extract to diabetic rats produced considerable reduction in serum lipase activity, that suggests its potential in prevention of lipid abnormalities and obesity (Bhandari et al 2013). 11 Ethanolic extract of Embelia Ribes has shown lipid lowering potential in terms of decrease serum total cholesterol, and triglycerides, and increase in HDLcholesterol levels in streptozotocin induced diabetes in rats after twenty days of oral administration at the dose of 200 mg/kg compared to pathogenic diabetic rats (Bhandari et al 2012). 12 Pretreatment with embelin (50 mg/kg) significantly decreased the elevated levels of serum lipid levels and lipoproteins in high fat diet induced obese rats (Chaudhari HS et al).…”