Antidiabetic Evaluation of Momordica charantia L Fruit Extracts

Tahira, S; Hussain, Fatma

doi:10.7727/wimj.2013.180

Cited by 17 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The specimens were further fixed with 10% neutral formalin, and histotomy sections of 4 μ m thickness were prepared in accordance with a general histological method. The slides were then stained with hematoxylin & eosin dye (H&E), and histopathological inspection was performed with a photomicroscope [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes‐Mimicking Mice

Baek

Jeong²,

Kwon

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The extract of the Momordica charantia fruit (MCE) is recognized as an alternative treatment for diabetes. The extract of Ligularia fischeri leaves (LFE) is traditionally used as a folk medicine for treating inflammatory diseases in Korea as well. In this study, we investigated the synergistic effect of MCE combined with LFE on antihyperglycemic and antihyperlipidemic potentials. Based on the α-glucosidase inhibitory effect and promotion of adipocyte differentiation in the 3T3-L1 cell line, the MLM was prepared with MCE:LFE (8:2 weight:weight). MLM showed the synergistic effects in the promotion of the glucose uptake rate, suppression of dipeptidyl peptidase-4 (DPP-4) mRNA expression, upregulation of an insulin receptor substrate and glucose transporter type-4 expression, and an increase in insulin-associated signaling in C2C12 cells. In addition, the efficacy of peroxisome proliferator-activated receptor-γ agonism and glucose uptake rate by MLM supplementation was significantly enhanced in vitro. Then, the antihyperglycemic and antihyperlipidemic effects of MCE, LFE, and MLM at the dose of 50, 100, and 200 mg/kg/day (n = 6 per each group) were determined in streptozotocin (STZ)-insulted mice fed an atherogenic diet (ATH) for 4 weeks. In addition, MLM (50, 100, and 200 mg/kg/day, n = 5 per each group) was supplemented in ATH-fed db/db mice for 10 weeks. Compared with MCE or LFE alone, MLM supplementation led to a more significant reduction of glucose levels in both STZ/ATH and db/db/ATH mice as well as lowered lipid profiles in STZ/ATH mice. In addition, the stimulation of islet of Langerhans regeneration was more pronounced by MLM supplementation in both mice models. In conclusion, antihyperglycemic and antihyperlipidemic effects were strengthened by the combined extracts of L. fischeri and M. charantia (MLM) in diabetes-mimicking mice.

show abstract

Section: Methodsmentioning

confidence: 99%

Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes‐Mimicking Mice

Baek

Jeong²,

Kwon

et al. 2018

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The fruits of M. charantia have been used not only as a vegetable but also as a traditional medicine. The uses or phytochemical properties of M. charantia from several literature reviews are antibacterial,[ 27 28 ] anticancer,[ 29 30 ] antidepressant,[ 31 ] antidiabetic,[ 32 33 34 ] antifungal,[ 35 36 ] anti-inflammatory,[ 37 38 ] antiobesity,[ 39 ] antioxidant,[ 40 41 ] antipyretic,[ 42 ] antiulcer,[ 43 44 ] and antiviral activities. [ 45 ] It also uses to treat the cardiovascular,[ 46 ] gout,[ 47 ] and hepatic diseases.…”

Section: Traditional Usesmentioning

confidence: 99%

An update review on the anthelmintic activity of bitter gourd, Momordica charantia

Poolperm¹,

Jiraungkoorskul²

2017

Phcog Rev

View full text Add to dashboard Cite

Momordica charantia (Family: Cucurbitales), as known as bitter melon or gourd, is a daily consumption as food and traditional medicinal plant in Southeast Asia and Indo-China. It has been shown to possess anticancer, antidepressant, antidiabetic, anti-inflammatory, antimicrobial, antiobesity, antioxidant, and antiulcer properties. Its common phytochemical components include alkaloids, charantin, flavonoids, glycosides, phenolics, tannins, and terpenoids. This plant is rich in various saponins including momordicin, momordin, momordicoside, karavilagenin, karaviloside, and kuguacin, all of which have been reported to contribute to its remedial properties including antibacterial, antifungal, antiviral, and antiparasitic infections. Based on established literature on the anthelmintic activity of M. charantia and possible mode of action, this review article has attempted to compile M. charantia could be further explored for the development of potential anthelmintic drug.

show abstract

“…[55] Similarly, Artemisia pallens Walls ex D.C. (Asteraceae) possesses various pharmacological properties such as antidiabetic, antioxidant, analgesic, and anti-inflammatory activity. [56] Crude ethanolic extract of Peucedanum japonicum Thunb has been identified as an antiobesity and antidiabetic candidate. [57] Leaves or whole aerial parts of wild bilberry (Vaccinium myrtillus L.) and northern highbush blueberry (Vaccinium corymbosum L.) cultivars [58] have been used as antidiabetic drugs mainly polyphenols [ Figure 1].…”

Section: Aegle Marmelosmentioning

confidence: 99%

Untitled

2016

IJGP

View full text Add to dashboard Cite

The present review explains the use of natural plant products for therapeutics of diabetes. It is a serious metabolic disorder that imposes multiple effects on human health. Although diabetes is curable, an erratic lifestyle always make panic and causes disease severity if proper medication is not being made available. Several ethnomedicines have been used by local people in form of crude extracts prepared from flowers, fruits, and roots of endemic plant species for cure of diabetes. There is a common usage of herbal parts for preparation of concoctions, syrups, vegetables, juices, green tea, from leaves, and roots for therapeutic purposes. This article explains antidiabetic effects of various plant secondary metabolites such as anthraquinones, flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and phytosterols. Daily meals containing good nutraceuticals such as protein and fiber can replace carbohydrate food that is a main source of glucose. Mainly, herbal foods rich in flavanols and polyphenols show hypoglycemic effects and can be used in the prevention of diabetes-induced vascular dysfunctions. Antidiabetic plant natural products restore insulin level and increase utilization of external glucose. Herbal dietary supplementation having diverse antioxidants, fibers, minerals, and antiglycants show inhibitory activity against α-amylase and α-glycosidase can easily control carbohydrate metabolism in humans. No doubt plant origin natural products can be used as alternative medicine for treatment of diabetes, but they must need proper composition and formulation before being used.

show abstract

Antidiabetic Evaluation of Momordica charantia L Fruit Extracts

Abstract: To investigate hypoglycaemic, hypolipidaemic and pancreatic beta cell regeneration activities of Momordica charantia L fruits (MC).

Cited by 17 publications

References 26 publications

Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes‐Mimicking Mice

Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes‐Mimicking Mice

An update review on the anthelmintic activity of bitter gourd, Momordica charantia

Untitled

Contact Info

Product

Resources

About