Antidiabetic modulatory effects of Vernonia amygdalina and Allium sativum combined extract in streptozotocin-induced diabetic rats

Imaga, Ngozi Awa; Iheagwam, Franklyn Nonso; Asibe, Comfort; Sogunle, Temiloluwa Boluwatife; Chinedu, Shalom Nwodo

doi:10.1007/s42535-022-00449-5

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…[37][38][39] Studies done using animal models also affirmed that supplementation of animal feed with plant enriched diets contribute to normalization of rats induced with diabetes. [40,41] The principles of prevention and management in T2DM include frequent blood glucose monitoring, reduction in carbohydrate and Therapy adjustment. Blood glucose monitoring before and after meal will enable early recognition of glucose abnormalities and allow prompt action to prevent several diabetic complications.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of remission of type 2 diabetes mellitus using a wholly Nigerian dietary intervention at University of Port Harcourt Teaching Hospital, Nigeria

Akoko

Siminialayi

Chinenye

2022

ijhs

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Background: The diagnosis of Type 2 diabetes mellitus is commonly associated with denial followed by a search for instant cure by spiritual intervention or herbal remedies. In the absence of effective health insurance policies in Nigeria, most treatments are paid for as out of pocket expenses, causing many with non-communicable diseases to go into poverty. The aim of this study is to evaluate the efficacy of a wholly Nigerian diet in achieving remission of type 2 diabetes mellitus. Method: Sixty study participants were randomized into matched control (standard of care) and treatment (dietary caloric restriction intervention) groups. Participants were followed for 24 weeks and samples taken at baseline, midline and at the end of the study for analysis. Results: While there was no change in mean HbA1c levels between baseline and at 6 months (8.390 ± 2.0242 compared to 8.140±2.1229), there was a statistically significant decrease in HbA1c value between baseline and at 6 months (7.617±2.0773 compared to 6.017±1.2301). Also, there was significant weight loss in the intervention group (mean waist circumference decreased from 88.82cm to 80.0cm [p=0.001] while BMI decreased from 22.67 to 22.86kg/m2 [p=0.025]).

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Section: Discussionmentioning

confidence: 99%

Feasibility of remission of type 2 diabetes mellitus using a wholly Nigerian dietary intervention at University of Port Harcourt Teaching Hospital, Nigeria

Akoko

Siminialayi

Chinenye

2022

ijhs

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“…We suggest that well-designed clinical studies be conducted to validate the antidiabetic properties of VA in human participants in regions where this medicinal plant is frequently used among indigenous communities, such as Ghana and Nigeria. Moreover, the synergistic effect of VA and other known antidiabetic medicinal plants such as Allium sativum [ 86 ] could be further exploited, as synergistic effect of bioactive compounds from medicinal plants has been proven to be promising and effective [ 87 ].…”

Section: Molecular Mechanisms Of Vernonia Amygdalina ...mentioning

confidence: 99%

Therapeutic Benefit of Vernonia amygdalina in the Treatment of Diabetes and Its Associated Complications in Preclinical Studies

Asante,

Wiafe

2023

Journal of Diabetes Research

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Diabetes mellitus (DM), a complex heterogeneous metabolic disorder characterized by a defect in the function of insulin, is on the rapid rise globally. Sustained hyperglycemia which is a major sign of DM is linked to the generation of reactive oxygen species which promotes adverse complications of the disorder. Traditional herbal treatment of DM is a common practice in Africa and other tropical parts of the world. Vernonia amygdalina (VA), one of the highly researched species in the Asteraceae family, has proven to possess potent antidiabetic properties. Several phytochemicals identified in multiple extracts from VA are purported to be responsible for the antidiabetic potential of the plant. In this review, we discuss the therapeutic potential of VA in diabetes and its associated complications. We appraise the current evidence and further suggest potential areas that could be effectively exploited in future VA research on diabetes.

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Antidiabetic modulatory effects of Vernonia amygdalina and Allium sativum combined extract in streptozotocin-induced diabetic rats

Cited by 2 publications

References 37 publications

Feasibility of remission of type 2 diabetes mellitus using a wholly Nigerian dietary intervention at University of Port Harcourt Teaching Hospital, Nigeria

Feasibility of remission of type 2 diabetes mellitus using a wholly Nigerian dietary intervention at University of Port Harcourt Teaching Hospital, Nigeria

Therapeutic Benefit of Vernonia amygdalina in the Treatment of Diabetes and Its Associated Complications in Preclinical Studies

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