Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

Nashar, Milka; Kiselova-Kaneva, Yoana; Ivanova, Diana

doi:10.5772/intechopen.85445

Cited by 2 publications

(3 citation statements)

References 133 publications

(73 reference statements)

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“…In this regard the potential of medicinal plants has been studied and remains not fully elucidated. In our previous studies we have established anti-obesity potential of agrimony in humans and rats [26]. Agrimonia eupatoria L. is a wide distributed herb, prescribed in folk medicine for the treatment of inflammatory diseases and as an antidiabetic remedy [29].…”

Section: Serum Lipid Parameterstotal Cholesterol (Tc) and Triglycerid...mentioning

confidence: 99%

“…Identification of herbal remedies and/or phytochemicals with anti-obesity properties would contribute to development of functional foods for prevention and treatment of this condition. In our previous studies we have established anti-obesity potential of agrimony (Agrimonia eupatoria L.) in humans and in rats [26] and impact on gene expression in cell cultures [19,21]. A. eupatoria has also been established to be rich in polyphenols and other biologically active substances with antioxidant and other biological properties [18].…”

Section: Introductionmentioning

confidence: 99%

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Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

Kiselova-Kaneva¹

2023

FARMACIA

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Potential of various herbs in regard to their ability to counteract obesity and related metabolic disturbances has been extensively studied. The aim of the current study was to assess the potential of Agrimonia eupatoria aqueous infusion (AE) to counteract fructose induced changes in serum total cholesterol (TC) and triglycerides (TG), the ratio of retroperitoneal adipose tissue weight/body weight and adipose tissue gene expression of the proteins Lipe, Fasn, Dgat, Hmgcr and adipokines AdipoQ and Plin. Twenty-four male Wistar rats were equally divided in to four groups -standard diet (ST); standard diet with AE (ST+AE); fructose overloaded (FR); fructose overloaded with AE (FR+AE). FR group showed significantly higher levels of TC, TG and adipose tissue weight relative to other groups. AE administration resulted in lower TC and TG levels, as compared to ST group (0.93 ± 0.43 mmol/L vs. 1.29 ± 0.57 mmol/L, p < 0.05 and 0.59 ± 0.1 vs. 0.91 ± 0.17 mmol/L, p < 0.001, respectively). Similarly, TC and TG were decreased also in ST+AE group (0.47 ± 0.21 mmol/L vs. 0.87 ± 0.57 mmol/L, p < 0.01 and 0.77 ± 0.15 vs. 0.92 ± 0.25 mmol/L, p < 0.05, respectively) in comparison to ST group. Gene expression analysis revealed a significant increase in Lipe (2.35 fold change, p < 0.05) and Hmgcr (2.86 fold change, p < 0.05) and a decrease (83%, p < 0.001) in Fasn mRNA levels in the FR group. AE consumption contributed to a significant decrease in the expression of Dgat2 (56%, p < 0.05) and Hmgcr (0.52%, p < 0.05) in Fr+AE group and of Fasn (71%, p < 0.001) in the ST+AE group. In conclusion, recent study demonstrated that Agrimonia eupatoria aqueous infusion intake improved total cholesterol and triglycerides imbalance in Wistar rats and modulated adipose tissue gene expression, which indicated that the herb might exert its favourable effects on adipose tissue possibly by preventing triglyceride synthesis and inducing mobilization of stored TG. RezumatÎn general, potențialul terapeutic al diferitelor plante pentru combaterea obezității și al dezechilibrelor metabolice asociate este intens studiat. Scopul prezentului studiu a fost de a evalua capacitatea infuziei apoase de Agrimonia eupatoria (AE) de a echilibra modificările induse de fructoză asupra valorilor colesterolului total (TC) și trigliceridelor (TG) din ser, de a echilibra raportul masă țesut adipos retroperitoneal/masă corporală, și de a modula expresia genelor pentru proteinele Lipe, Fasn, Dgat, Hmgcr și adipokinele AdipoQ și Plin din țesutul adipos. Douăzeci și patru de șobolani albi Wistar au fost împărțiți în patru loturi, care au primit următoarele diete: dietă standard (ST); dietă standard cu AE (ST+AE); supliment de fructoză (FR); supliment de fructoză cu AE (FR+AE). Lotul FR a prezentat nivele semnificativ crescute ale TC, TG și ale masei de țesut adipos, comparativ cu celelalte loturi. Administrarea de AE a condus la o scădere a valorilor TC şi TG comparativ cu lotul ST (0,93 ± 0,43 mmol/L față de 1,29 ± 0,57 mmol/L, p < 0,05 și, respectiv 0,59 ± 0,1 față de 0,91 ±...

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Section: Serum Lipid Parameterstotal Cholesterol (Tc) and Triglycerid...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

Kiselova-Kaneva¹

2023

FARMACIA

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“…Phytopharmacological studies of various medicinal plants refer to traditional medicine as a source of ideas [17,[19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Traditional Knowledge of Medicinal Plants in Relation to Local Customs and Practices of the North Black Sea Coast Population

Cherneva¹,

Ivanov

2023

Acta Scientifica Naturalis

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This comprehensive ethnobotanical study was conducted along the North Black Sea coast area to find of the extent to which indigenous knowledge of medicinal plants and their relation to Bulgarian traditions and customs is preserved. We aim to identify the tendencies of passing this knowledge to future generations. The survey was conducted in 2015 in various urban and rural North Black Sea coast areas, using a face-to-face interviews technique. We used the Chi-square test to analyse the results. Pearson correlation coefficient was used for the assessment of the impact of demographics on respondents' answers. More than half of the respondents (61.08%) are not familiar with rituals and traditional practices related to medicinal plants. Moderate influence on respondents' answers is rendered by age only. For the local population of the North Black Sea coast, Enyovden turns out to be the most popular holiday related to medicinal plants. Enyovden is the herbalists' feast and is cited by 20% of respondents. The same percentage of interviewees mention Geranium spp. and Ocimum basilicum L. as the most favoured herbs related to local traditions and customs. Traditional knowledge of the relation between Bulgarian rituals and customs to medicinal plants and their magical powers is fading.

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Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

Cited by 2 publications

References 133 publications

Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

Fructose Induced Changes in Rat Serum Lipids and Adipose Tissue Gene Expression and Preventive Effects of Agrimonia Eupatoria Aqueous Infusion Intake

Traditional Knowledge of Medicinal Plants in Relation to Local Customs and Practices of the North Black Sea Coast Population

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