Antidiabetic Principle in Cucumis sativus L.

Abstract

Diabetes is one of the leading cause of death globally. One of the strategies towards managing diabetes is the antidiabetic drugs which has recorded a huge success but accompanied with different degrees of side effect, hence, the use of natural plants products is encouraged. Several reports of antidiabetic medicinal plants have flooded literature but few has led to identification of active ingredient in such. Cucumis sativus is one of such plants reported to have antidiabetic property but there is little or no data on the active agent. This chapter therefore provides report on the active principle and mechanism of action underlying the antidiabetic activity of C. sativus.

Separate and Combined Effects of Resistance Training and Cucumber (Cucumis sativus) Juice Consumption on the Diabetic Indicators and Lipid Profile in Women with Type 2 Diabetes

“…Kaempferol has anti-inflammatory, anti-cancer, and anti-diabetic properties, which protect the liver and prevent metabolic diseases. Kaempferol has been reported to lower blood sugar and inhibit alpha-amylase and alpha-glucosidase (two carbohydrate-hydrolyzing enzymes found in the digestive tract) (25). Ibitoye et al showed that kaempferol isolated from cucumber inhibits alpha-amylase and alpha-glucosidase enzymes with anti-diabetic properties and hypoglycemic and antioxidant activities (26).…”

Quantitative analysis of Phytochemical Constituents and Antioxidant Efficiency of Cucumis prophetarum L.

“…3 They are also rich in flavonoids and polyphenols that exhibit antidiabetic activity. 4 The fruits of Cucumis trigonus contain steroid and triterpenoid compounds, cucurbitacin B and proteolytic enzymes and it showed analgesic and anti-inflammatory activities. C. prophetarum has also been testified to have various biological activities as abortifacient and antihepatotoxic in the treatment of liver diseases.…”