Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

Hartogh, Danja J. Den; Gabriel, Alessandra; Tsiani, Evangelia

doi:10.3390/nu12010058

Cited by 71 publications

(48 citation statements)

References 92 publications

(154 reference statements)

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“…Recent evidence emphasized the anti-hyperglycemic activity of curcumin, both in animals and humans [ 40 ]. Specifically, this compound had the capability to improve glucose uptake, insulin sensitivity, and pancreatic β-cell function, as well as liver and kidney function, and to reduce glucose and lipid levels, oxidative stress, and inflammation [ 41 ], by interacting with almost all the players involved in these processes, as demonstrated in in vitro studies [ 13 , 41 ].…”

Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases in humans, limited and fragmentary information is currently available about curcumin’s effects on pregnancy and pregnancy-related complications. It is known that immune-metabolic alterations occurring during pregnancy have consequences on both maternal and fetal tissues, leading to short- and long-term complications. The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. The current review summarizes the latest data, mostly obtained from animal models and in vitro studies, on the impact of curcumin on the molecular mechanisms involved in pregnancy pathophysiology, with the aim to shed light on the possible beneficial and/or adverse effects of curcumin on pregnancy outcomes.

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Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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“…To date, highly absorbed curcumin preparations have been demonstrated to have the following effects on various illnesses: improved QOL in patients with end-stage pancreatic cancer [26]; improved memory function and reduced amyloid-β/tau protein accumulation in patients with mild cognitive impairment [27]; improvement of moderate Crohn's disease [28]; alleviation of pain in patients with knee osteoarthritis [29][30][31]; and decreased levels of α1-antitrypsin-LDL, a form of oxidized LDL in blood, and possible reduction of cardiovascular risk in patients with moderate chronic obstructive pulmonary disease [32]. Many animal experiments have revealed the potential of curcumin as a therapeutic agent for hypertension and myocardial infarction-induced heart diseases [33,34], diabetes [35], obesity [36], and atherosclerosis [37]. curcuRouge™ developed in this study is considered to have a higher bioavailability than Theracurmin® and other absorption-improved preparations, such as BCM-95® and Meriva®.…”

Section: Discussionmentioning

confidence: 99%

A Novel Amorphous Curcumin Preparation Improved Oral Absorption Efficiency in Healthy Volunteers: A Single-Dose, Double-Blind, Two-Way Crossover Study

Sunagawa

Miyazaki

Funamoto

et al. 2020

Preprint

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Background: Curcumin has diverse biological activities such as anti-cancer, antioxidant, and anti-inflammatory properties and is assumed to exhibit beneficial effects in the prevention and treatment of various diseases. Although curcumin is known to be safe in humans, its therapeutic efficacy is limited owing to its poor bioavailability. To overcome this problem, we prepared a novel curcumin preparation curcuRougeTM using the amorphous solid dispersion method. In this study, we aimed to investigate the oral absorption efficiency of curcuRougeTM and compare its efficiency with that of Theracurmin®, a highly absorptive curcumin preparation dispersed with colloidal submicron-particles exhibiting improved bioavailability, in rats and healthy volunteers. Methods: In the animal experiment, male Sprague–Dawley rats were orally administered curcuRougeTM or Theracurmin® (10 mg/kg of curcumin). The plasma curcumin levels were measured at 0.25, 0.5, 1, 2, 4, and 6 h after administration. In addition, we performed a single-dose, double-blind, two-way crossover study to compare plasma curcumin levels after the administration of curcuRougeTM or Theracurmin® in humans. Twelve healthy volunteers were administered curcuRougeTM or Theracurmin® containing 30 mg curcumin. The plasma curcumin concentrations at 0.5, 1, 2, 4, and 8 h after ingestion were determined. Results: The area under plasma concentration–time curve (AUC0-6 h) and maximum plasma concentration (Cmax) of curcuRougeTM in rats were 3.7- and 9.6-fold higher than those of Theracurmin®, respectively. Twelve healthy volunteers were orally administered 90 mg of curcuRougeTM or Theracurmin® in a randomized double-blind crossover study. In these volunteers, the AUC0-8 h and Cmax of curcuRougeTM were 3.4-fold and 5.4-fold higher than those of Theracurmin®, respectively. Conclusion: These findings indicate that curcuRougeTM shows better bioavailability than other highly absorptive curcumin preparations, such as Theracurmin®. Hence, curcuRougeTM is assumed to exhibit clinical efficacy for managing various diseases at a low dose.Trial registration: The trial was registered with the UMIN Clinical Trials Registry (January 8, 2020, UMIN000039083, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000044573).

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“…Increased oxidative stress, inflammation and stress activated protein kinases inhibit insulin-induced IRS1 tyrosine phosphorylation in diabetes [16]. Plenty of studies reported that curcumin enhanced the insulin signaling and increased the insulin sensitivity through reduction oxidative stress and decrease in TNF alpha and NFkB activations in STZ induced diabetic rats [9,15]. Curcumin treatment stimulated the level of IRS1 phosphorylation in rat insulinoma cells and improved the high glucose-induced insulin resistance [17].…”

Section: Discussionmentioning

confidence: 99%

“…Many studies showed that blood glucose level can be reduced by curcumin treatment through decrease in hepatic glucose production, inhibiting hyperglycemiainduced inflammation, reduction of insulin resistance and inducing glucose uptake [9]. Peeyush et al showed that curcumin treatment significantly normalized the diabetic cerebellar disorder in STZ induced diabetic rats [10].…”

Section: Introductionmentioning

confidence: 99%

Effect of curcumin on activation and expression of IRS1, Grb2, K-Ras and Bax in STZ-induced diabetic rat brains

et al. 2020

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Aim: Diabetes mellitus leads to development of neuropathy as a secondary complication. The main mechanism of diabetic neuropathy is the dysregulation of energy balance and glucose homeostasis in brain. This study aimed to examine the effects of curcumin as an antidiabetic compound on the expressions of IRS1, Grb2, K-Ras and Bax proteins in diabetic rat brains. Material and Methods: 16 Wistar albino rats were divided randomly into four groups as: control, curcumin; STZ-treated and STZ+Curcumin treated groups. The rats in STZ group were induced to develop diabetes by intraperitoneal administration of STZ. Then, they were treated with curcumin daily by gavage. Expressions and activation of IRS1, Grb2, K-Ras and Bax were determined by western blot analyses. Results: Western blot analyses showed that curcumin treatment increased IRS1 tyrosine phosphorylation and it reversed the negative effect of STZ on IRS1 activation. K-Ras expression significantly decreased while Bax expression increased in STZ group (p<0.05). No significant changes in the expressions of Grb2 and IRS1 were observed for all groups. Conclusion: Based on the results, it could be suggested that curcumin treatment significantly reversed the negative effects of STZ on insulin signaling pathway members in STZ induced diabetic rat brains.

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Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies

Cited by 71 publications

References 92 publications

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

A Novel Amorphous Curcumin Preparation Improved Oral Absorption Efficiency in Healthy Volunteers: A Single-Dose, Double-Blind, Two-Way Crossover Study

Effect of curcumin on activation and expression of IRS1, Grb2, K-Ras and Bax in STZ-induced diabetic rat brains

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