Antidiabetic screening and scoring of 11 plants traditionally used in South Africa

Venter, Maryna van de; Roux, Saartjie; Bungu, Lelethu C.; Louw, Johan; Crouch, Neil R.; Grace, Olwen M.; Maharaj, Vinesh; Pillay, Priyen; Sewnarian, Prenitha; Bhagwandin, Niresh; Folb, Peter I.

doi:10.1016/j.jep.2008.05.031

Cited by 146 publications

(106 citation statements)

References 23 publications

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“…The in vitro anti-diabetic and toxicity screening were done by using an adapted method described by Van de Venter et al (2008). This method measures glucose utilization, which can be used for long-term exposure of the cells to the sample.…”

Section: In Vitro Anti-diabetic and Toxicity Screeningmentioning

confidence: 99%

“…1) extracts. The toxicity of these plant extracts in C2C12 myocytes was not determined because of the short exposure time of the cells to the plant extracts (Van de Venter et al, 2008).…”

Section: In Vitromentioning

confidence: 99%

“…The results obtained were interpreted by making use of the scoring system developed by Van de Venter et al (2008) to determine which plant to further analyze. According to this scoring system the potential anti-diabetic activity as well as the toxicity of the plant extract is taken into consideration to assist in the selection of the most active and least toxic plant extract (Table 1).…”

Section: In Vitromentioning

confidence: 99%

“…Effect of plant extracts on glucose utilization and toxicity in Chang liver cells, 3T3-L1 preadipocytes and C2C12 myocytes using the scoring system of Van de Venter et al (2008).…”

Section: Tablementioning

confidence: 99%

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Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Deutschländer

Venter

Roux

et al. 2009

Journal of Ethnopharmacology

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a b s t r a c tAim: To validate plant species for hypoglycaemic activity. Materials and methods: Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: ␣-glucosidase and ␣-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadipocytes and Chang liver cells by measuring glucose uptake. Cytotoxicity was done in preadipocytes and hepatocytes. Results: Extract of Euclea undulata rootbark exhibited highest activity, displaying a glucose uptake of 162.2% by Chang liver cells at 50 g/ml. An inhibition concentration of 50% for Euclea undulata was found to be 49.95 g/ml for ␣-glucosidase and 2.8 g/ml for ␣-amylase. No cytotoxicity was recorded for Euclea undulata, while Schkuhria pinnata and Elaeodendron transvaalense exhibited cytotoxicity at 12.5 g/ml. ␣-Glucosidase and ␣-amylase assays showed inhibitory activity on enzymes for three plant extracts. Conclusion: Euclea undulata, Schkuhria pinnata and Elaeodendron transvaalense showed in vitro hypoglycaemic activity. Schkuhria pinnata and Elaeodendron transvaalense indicated cytotoxicity on 3T3-L1 preadipocytes and Chang liver cells. Euclea undulata, Pteronia divaricata and Elaeodendron transvaalense inhibited ␣-glucosidase and ␣-amylase enzymes. Ethnopharmacological relevance: Screening of plant extracts scientifically validated traditional use of Euclea undulata for treatment of diabetes. Cytotoxicity results revealed that acetone extracts of Schkuhria pinnata and Elaeodendron transvaalense are toxic and raise concern for chronic use.

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Section: In Vitro Anti-diabetic and Toxicity Screeningmentioning

confidence: 99%

“…1) extracts. The toxicity of these plant extracts in C2C12 myocytes was not determined because of the short exposure time of the cells to the plant extracts (Van de Venter et al, 2008).…”

Section: In Vitromentioning

confidence: 99%

Section: In Vitromentioning

confidence: 99%

“…Effect of plant extracts on glucose utilization and toxicity in Chang liver cells, 3T3-L1 preadipocytes and C2C12 myocytes using the scoring system of Van de Venter et al (2008).…”

Section: Tablementioning

confidence: 99%

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Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Deutschländer

Venter

Roux

et al. 2009

Journal of Ethnopharmacology

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“…Alkaloid rich extract derived from M. inermis induced a strong inhibition of protein synthesis in mammalian cells but did not exhibit mutagenic or genotoxic activity Traore et al (2000) Momordica balsamina In vitro toxicity results raise concern for chronic use van de Venter et al (2008) Nauclea latifolia…”

Section: Mitragyna Inermismentioning

confidence: 99%

Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review

Yagi¹,

Yagi²

2018

Afr. J. Pharm. Pharmacol.

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Sclerocarya birrea (a. rich) hochst. [‘marula’] (anacardiaceae): a review of its phytochemistry, pharmacology and toxicology and its ethnomedicinal uses

Ojewole

Mawoza

Chiwororo

et al. 2009

Phytotherapy Research

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A plethora of ethnotherapeutic properties and pharmacological actions have been attributed to Sclerocarya birrea (family: Anacardiaceae). It is one of the most highly valued indigenous trees of southern Africa. Reports in biomedical literature have indicated the presence of medicinally-important chemical constituents in the plant, notably: polyphenols, tannins, coumarins, flavonoids, triterpenoids, phytosterols, and so forth. Pharmacological studies by various groups of investigators have shown that S. birrea possesses antidiarrhoeal, antidiabetic, anti-inflammatory, antimicrobial, antiplasmodial, antihypertensive, anticonvulsant, antinociceptive and antioxidant properties, thus lending pharmacological support to the plant's folkloric, ethnotherapeutic uses in South African traditional medicine. In view of the immense medicinal importance of the plant, this review aimed at compiling all currently available information on S. birrea's chemical constituents, as well as its ethnomedicinal, pharmacological and toxicological properties.

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Antidiabetic screening and scoring of 11 plants traditionally used in South Africa

Cited by 146 publications

References 23 publications

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Hypoglycaemic activity of four plant extracts traditionally used in South Africa for diabetes

Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review

Sclerocarya birrea (a. rich) hochst. [‘marula’] (anacardiaceae): a review of its phytochemistry, pharmacology and toxicology and its ethnomedicinal uses

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