Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae)

Birru, Eshetie Melese; Asrie, Assefa Belay; Adinew, Getnet Mequanint; Tsegaw, Asegedech

doi:10.1186/s12906-016-1252-4

Cited by 35 publications

(40 citation statements)

References 34 publications

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“…Phytochemical screening study showed that the leaves extract of Ruta chalepensis was endowed with alkaloids, flavonoids, polyphenols, terpenoids, cardiac glycosides, and saponins. [22] Previous studies showed that terpenoids and steroids like phytosterols have a capacity to inhibit the production of prostaglandin E2 [23,24], which has a crucial role in the stimulation of intestinal secretions. [25,26] Accordingly, the significant antidiarrheal activity observed in the Ruta chalepensis crude extract at different doses could probably be linked to the presence of these secondary metabolites in the crude extract.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antidiarrheal Activity of Hydromethanol Crude Extracts of Ruta chalepensis and Vernonia amygdalina in Mice

Degu

Kefale

Alemayehu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. The herbal medicine practitioners in Ethiopia have used a wide range of medicinal plants as antidiarrheal agents. Among these, Ruta chalepensis and Vernonia amygdalina were claimed to have antidiarrheal activity in Ethiopian folklore medicine. Hence, the aim of the present study was to evaluate the antidiarrheal activity of the crude extracts of Ruta chalepensis and Vernonia amygdalina in mice. Methods. The crude extracts were obtained by cold maceration with 80% methanol, and its antidiarrheal activities were evaluated using a castor oil-induced diarrheal model. The test groups were treated with 100, 200, and 400 mg/kg body weight (bw) of the crude extract of each plant, while the positive controls and negative controls were given loperamide (3 mg/kg.bw) and 2% Tween 80 (10 ml/kg.bw), respectively. Results. In the castor oil-induced model, the crude extract of Ruta chalepensis (200 and 400 mg/kg.bw) significantly prolonged the onset of diarrhea in mice. Besides, it also showed a significant reduction in the frequency of stooling and weight of feces. Contrastingly, the crude extract of Vernonia amygdalina had a significant effect in delaying the onset of time of diarrhea and reduction of the frequency of stool and the weight of feces only at the maximum tested dose (400 mg/kg.bw). Conclusion. The present study demonstrated that the crude leaves extract of Ruta chalepensis (200 and 400 mg/kg.bw) and Vernonia amygdalina (400 mg/kg.bw) possessed significant antidiarrheal activity in the castor oil-induced diarrheal model.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Antidiarrheal Activity of Hydromethanol Crude Extracts of Ruta chalepensis and Vernonia amygdalina in Mice

Degu

Kefale

Alemayehu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Constipation and diarrhea are two distinct antagonistic disorders characterized by an imbalance in intestinal absorption/secretion leading to unexplained abdominal pain, discomfort and bloating in association with altered bowel habits (Birru and others ).…”

Section: Discussionmentioning

confidence: 99%

Reverse Effect ofOpuntia ficus‐indicaL. Juice and Seeds Aqueous Extract on Gastric Emptying and Small‐Bowel Motility in Rat

Rtibi

Selmi

Saidani

et al. 2017

Journal of Food Science

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This study was conducted to compare the effects of juice and seeds on gastric emptying, small-bowel motility and intestinal ion transport. Separate groups of rats were randomized to receive NaCl, increasing doses of juice (5, 10, and 20 mL/kg, b.w.) or seeds aqueous extract (100, 200, and 400 mg/kg, b.w.). Simultaneously, two other groups were received, the reference drugs; clonidine (1 mg/kg) and yohimbine (2 mg/kg). The charcoal meal was used as a suspension for gastrointestinal motility test. The purgative action of juice was confirmed using the loperamide (5 mg/kg, p.o.) induced constipation. To evaluate the antisecretory effect, we were used as a hypersecretion agent, the castor oil at the dose of 5 mL/kg. Compared to the control and standard groups, we were showed that the prickly pear has an opposite effect on small-bowel motility and gastric emptying. Indeed, the juice at various doses has a laxative effect of gastrointestinal transit in healthy and constipated-rats. However, the aqueous extract of the seeds leads to a reduction of motility in normal rats which gives it a remarkable antidiarrhoeal activity, a notable intestinal fluid accumulation decline and electrolyte concentrations reestablishment. Moreover, orally juice administered at different doses accelerated the stomach emptying time in contrast to the seeds aqueous extract. More importantly, a significant variation in the phytochemical constituents levels between juice and seeds was found. These findings confirm the reverse therapeutic effects of this fruit in the treatment of digestive disturbances such as difficulty stool evacuation and massive intestinal secretion, likewise, the gastric emptying process perturbation.

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“…Statistical significance of differences between groups was assessed by one-way ANOVA followed by post-hoc Tukey's multiple comparison test. The results were considered significant at p-value < 0.05 [18][19].…”

Section: Methodsmentioning

confidence: 99%

Antidiarrheal activity of ethanolic extract of leaves of Sangkareho (Callicarpa longifolia Lam) from Central Kalimantan

2019

Lett Appl NanoBioSci

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Diarrhea is one of the leading causes of preventable death in developing countries including in Indonesia and Malaysia. It has been reported that the leaves of sangkareho (Callicarpa longifolia Lam) is used traditionally as an antidiarrheal treatment in Central Kalimantan. The present study was aimed to evaluate the pharmacological activity against diarrhea using the ethanolic extract of sangkareho leaves. The extract was used for castor oil-induced diarrhea in mice. The extracts were given orally to the mice at 200, 300, 400 mg/kg bodyweight and loperamide was used as a standard drug for diarrhea. The results showed % inhibition of diarrhea with values of no detected, 42.62%, 81.97%, 70.49% at 200, 300, 400 mg/kg bodyweight dose levels of the extract and loperamide, respectively as compared to the negative control. It can be considered at a dose level of 400 mg/kg bodyweight the extract has a greater anti-diarrheal effect than loperamide. In conclusion, ethanolic extract of sangkareho leaves (Callicarpa longifolia Lam) has anti-diarrheal activity and this supports the use of this plant as antidiarrhea in traditional treatment.

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Antidiarrheal activity of crude methanolic root extract of Idigofera spicata Forssk.(Fabaceae)

Cited by 35 publications

References 34 publications

Evaluation of the Antidiarrheal Activity of Hydromethanol Crude Extracts of Ruta chalepensis and Vernonia amygdalina in Mice

Evaluation of the Antidiarrheal Activity of Hydromethanol Crude Extracts of Ruta chalepensis and Vernonia amygdalina in Mice

Reverse Effect ofOpuntia ficus‐indicaL. Juice and Seeds Aqueous Extract on Gastric Emptying and Small‐Bowel Motility in Rat

Antidiarrheal activity of ethanolic extract of leaves of Sangkareho (Callicarpa longifolia Lam) from Central Kalimantan

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