Antidiarrheal activity of hexane extract of Citrus limon peel in an experimental animal model

Adeniyi, Olasupo Stephen; James, Omale; Omeje, Samuel Chukwuma; Edino, Victoria Ojimaojo

doi:10.1016/s2095-4964(17)60327-3

Cited by 22 publications

(20 citation statements)

References 23 publications

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“…The laxative and abortifacient activities of castor seeds were attributed to the activation of intestinal and uterine smooth-muscle cells via prostaglandin EP3 receptors induced by ricinoleic acid [12]. Castor oil-induced diarrhea can be antagonized by hexane extract of Citrus limon peel that activates antisecretory and antimotility mechanisms through the β adrenergic system [13]. The purgative and anthelmintic actions of the oral ingestion of castor seeds, at least in part, could also be ascribed to the irritative effect caused to intestine by ricin, as reported in toxicological studies (reviewed in [14]).…”

Section: Castor Bean In Traditional and Folk Medicinementioning

confidence: 99%

Ricin: An Ancient Story for a Timeless Plant Toxin

Polito¹,

Bortolotti²,

Battelli³

et al. 2019

Preprint

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The castor plant (Ricinus communis L.) has been known since time immemorial in traditional medicine in the pharmacopeia of Mediterranean and eastern ancient cultures. Moreover, it is still used in folk medicine worldwide. Castor bean has been mainly recommended as anti-inflammatory, anthelmintic, anti-bacterial, laxative, abortifacient, for wounds, ulcers, and many other indications. Many cases of human intoxication occurred accidentally or voluntarily with the ingestion of castor seeds or derivatives. Ricinus toxicity depends on several molecules, among them the most important is ricin, a protein belonging to the family of ribosome-inactivating proteins. Ricin is the most studied of this category of proteins and it is also known to the general public, having been used for biocrimes in several cases. Here, the main steps of ricin research are reported with particular regards to its enzymatic activity, structure and cytotoxicity. Moreover, we discuss ricin toxicity for animals and humans, as well as the relation amongst bioterrorism and ricin and its impact on environmental toxicity. Ricin has also been of great utility to develop a number of immunotoxins specific for the elimination of unwanted cells, mainly cancer cells; some of these immunotoxins gave promising results also in clinical trials.

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Section: Castor Bean In Traditional and Folk Medicinementioning

confidence: 99%

Ricin: An Ancient Story for a Timeless Plant Toxin

Polito¹,

Bortolotti²,

Battelli³

et al. 2019

Preprint

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“…These occurrences usually followed by increased propulsion [48]. Adeniyi et al [50] reported the citrus peels′ benefits in reducing the occurrences of passage of wet feces. Besides, the inhibition of accumulating intestinal fluid and reduction in intestinal motility by stimulating the βadrenergic receptors of intestine were also elucidated.…”

mentioning

confidence: 99%

“…Stimulation of αand β-adrenergic receptors inhibits the rate and force of intestinal contraction [51,52]. When β-receptors were inhibited, the inhibition of fluid secretion in intestine was significant, hence exerted citrus peels′ antidiarrheal effect [50,[53][54][55]. Therefore, it is determined that adrenergic pathway inhibition aids the blockage of fluid secretion in the gut hence diarrhea occurrence can be stopped [56,57].…”

mentioning

confidence: 99%

“…Adeniyi et al [50] revealed that Citrus limon′s peel extract significantly reduced the frequency of wet fecal pellets in animal model [58]. Hexane extraction of Citrus limon peel (HECLP) showed that it reduced the highest percentage inhibition of wet fecal pellets.…”

mentioning

confidence: 99%

“…The mechanism involved was antisecretory and antimotility of adrenergic pathway where the β-receptors were blocked and thus no fluid secretion and intestinal fluid accumu-lation was insignificant. Hence, C. limon peel showed a high potential in combating diarrhea hence it possesses antidiarrheal effects [50,58].…”

mentioning

confidence: 99%

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Citrus Peel as a Source of Beneficial Phytochemical and Pharmacological Potential

Abidin¹,

Bakar²,

Anuar³

et al. 2019

Asian J. Chem.

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Citrus plant is native to tropical Asia. Despite that it is also found in all tropical and subtropical country. The worldwide annual production of citrus fruits is 105 million metric tons between 2000 and 2004 [1] and has been increasing steadily throughout 2000s reaching over 124 million tonnes by 2016 [2]. Citrus fruits belong to the family Rutaceae of the genus Citrus. Which includes fruits such as tangerine, orange, lemon, lime and grapefruit. Citrus fruits are well-known as a source of beneficial nutrients as well as phenolic compounds which are for human health. In major citrus producing countries such as Brazil and the United States, the percentage of fruits being utilized into juices reaches 96 % while the average percentage is 34 % [1]. Based on the average yield of juices, peel of citrus covers a big part of surplus [1,3-5]. Owing to a large amount of waste produced, fermentation of the waste is affecting the environment. Citrus by-products which eventually discarded

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Value‐Added Products from Fruit and Vegetable Wastes: A Review

Sánchez

Laca

et al. 2021

CLEAN Soil Air Water

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Fruit and vegetable wastes (FVW) are some of the most abundant agro‐industrial wastes. This residual biomass can be used to obtain biofuels such as bioethanol, biomethane, biohydrogen, and biobutanol. Additionally, FVW can also be employed as a raw material for recovering bioactive compounds (antioxidants, enzymes, or antibiotics) and to produce organic acids of industrial interest (citric acid, lactic acid, acetic acid). However, the use of these wastes as a substrate to obtain the mentioned value‐added products usually requires several steps, including different pre‐treatments, microbial biotransformation, and separation and purification processes. The aim of this work is to provide an overview of the different products that can be obtained from FVW, as well as the technologies that can be employed in the revalorization procedures.

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Antidiarrheal activity of hexane extract of Citrus limon peel in an experimental animal model

Cited by 22 publications

References 23 publications

Ricin: An Ancient Story for a Timeless Plant Toxin

Ricin: An Ancient Story for a Timeless Plant Toxin

Citrus Peel as a Source of Beneficial Phytochemical and Pharmacological Potential

Value‐Added Products from Fruit and Vegetable Wastes: A Review

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