Antidiarrheal Activity of the Ethyl Acetate Extract of Morinda morindoides in Rats

Souleymane, Méité; N'guessan, J. D.; Calixte, Bahi; Yapi, HF; Djaman, AJ; Guina, FG

doi:10.4314/tjpr.v8i3.44533

Cited by 71 publications

(72 citation statements)

References 25 publications

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“…The liberated ricinoleic acid also causes irritation and inflammation of the intestinal mucosa leading to the release of endogenous prostaglandins. Other mechanisms of castor oil induced diarrhea include inhibition of intestinal Na+/K+ -ATPase activity, activation of adenylate cyclase or mucosal cAMP mediated active secretion and platelet activating factor (Meite et al, 2009). The decrease in the wetness of feces and the frequency of defecation as well as the decrease in the intensity and frequency of body squirming observed, proved the potent antidiarrhoeal and analgesic activities of P. neriifolius leaves which might be due to the inhibition of prostaglandins biosynthesis.…”

Section: Resultsmentioning

confidence: 99%

Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

Razan

Tahia²,

Hossain

et al. 2016

Bangla Pharma J

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The methanol extract of leaf of Podocarpus neriifolius D. Don exhibited in vivo peripheral analgesic and antidiarrheal activities in Swiss Albino mice. In the peripheral analgesic activity assay, the methanolic extract showed 50.00 ± 8.57% and 70.25 ± 1.18% inhibition of acetic acid-induced writhing at 200 and 400 mg/kg body weight, respectively. In addition, the extract also revealed a dose dependant inhibition of castor oilinduced diarrhea with 43.77 ± 3.13% and 56.23 ± 6.49% inhibition of feces at 200 and 400 mg/kg body weight, respectively.

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Section: Resultsmentioning

confidence: 99%

Analgesic and Antidiarrheal Activities of Leaf of Podocarpus neriifolius D. Don

Razan

Tahia²,

Hossain

et al. 2016

Bangla Pharma J

View full text Add to dashboard Cite

show abstract

“…This variation in body weight was small and not significant in female rats. The decline in the stools emission in all treated animals would be correlated with the presence of anti-diarrheal compounds and antimotility such as saponins, terpenes, phenols, anthraquinones and anthocyanidins [22] in our extract, or could be due to the decline in food intake which it would be due to the anti-nutritional compounds such as tannins [21]. Assessment of liver and kidney function is a very vital index in evaluating the toxicity of drugs and plant extracts.…”

Section: Discussionmentioning

confidence: 99%

Acute and Subchronic Oral Toxicity Studies of an Ethanol/Water Extract of <i>Euphorbia scordifolia </i>Jacq (Euphorbiaceae) in Mice and in Rats

Fokam

Noubissi

Kamgang

2017

IJPPE

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Abstract. Euphorbia scordifolia is used in Cameroon as galactagogue and in the treatment of gastrointestinal disorders. This work was undertaken to evaluate the acute and subchronic toxicities of ethanol/water extract of Euphorbia scordifolia (EWEs). Acute toxicity study was carried out by oral administration of 1, 2, 3, 4 and 5 g/kg body weight of EWEs to mice in the respective groups. Subchronic toxicity study was conducted by oral administration of the extract at daily doses of 50, 75 and 100 mg/kg body weight to another group of rats for 28 days, while rats in the control group received 10 mL/kg body weight of distilled water. Following the 28-day treatment, the rats were sacrificed for hematological, biochemical and histopathology studies. In the acute toxicity study, EWEs was found to be non-toxic at a dose of 5000 mg/kg body weight. The subchronic treatment with EWEs did not alter either the body weight gain or the food and water consumption. Biochemical analysis did not show any significant differences in any of the parameters examined in males or females. Hematological analysis showed a significant decrease (P<0.01) in white blood cells and red blood cells in males treated with 100 mg/kg bw and a significant (P<0.01) decrease in hemoglobin and hemoglobin hematocrit in all treated females. Necropsy and histopathological examination revealed some slight hepatic necrosis with the dose 100 mg/kg bw. It would be necessary to use the ethanol/water extract for short periods (<4 weeks). Thus, the plant, at least its ethanol/water extract, could be considered with a wide margin of safety for short-term oral use.

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“…Diarrhea is another common disease in developing countries especially in children and is responsible for the death of millions of people each year [3] . Medicinal plants are a gifted source especially for anti-diarrheal drugs [4] . For this motive, to combat the problem of diarrhea in developing countries, the World Health Organization in its Diarrheal Disease Control programme has encouraged to use traditional folklore medicines in the treatment and prevention [3,5] .…”

Section: Introductionmentioning

confidence: 99%