Antidiarrheal activity of α-terpineol in mice

Negreiros, Polyanna dos Santos; Costa, Douglas Soares da; Silva, Valdelânia Gomes da; Lima, Izabela Borges de Carvalho; Nunes, Daniel Barbosa; Sousa, Francisca Beatriz de Melo; Araújo, Thiago de Souza Lopes; Medeiros, Jand Venes R.; Santos, Rivaldo Vital dos; Oliveira, Rita

doi:10.1016/j.biopha.2018.11.131

Cited by 38 publications

(15 citation statements)

References 49 publications

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“…Figure 6a,b shows that intraluminal injection of RAG (60 mg/kg) decreased CT-induced intestinal fluid secretion by 0.095 ± 0.008 g/cm for the CT-treated group versus 0.046 ± 0.005 g/cm for the RAG treated group (p < 0.05) after 4 hours. These early results show that RAG is able to reduce fluid production after four hours of cholera toxin-induced diarrhea, as reported by [57], [73], and [74], proving the action of different types of natural products against cholera toxin-induced diarrhea.…”

Section: Evaluation Of Rag On Cholera Toxin-induced Fluid Secretion Isupporting

confidence: 72%

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Araújo

Oliveira²,

Sousa

et al. 2020

Pharmaceuticals

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Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the antidiarrheal activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm−1, 1368 cm−1, and 1029 cm−1, which relate to the vibration of O–H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 105 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.

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Section: Evaluation Of Rag On Cholera Toxin-induced Fluid Secretion Isupporting

confidence: 72%

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Araújo

Oliveira²,

Sousa

et al. 2020

Pharmaceuticals

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“…In another rodent study, α-terpineol presented high antidiarrheal potential in models of acute diarrhea in Swiss mice (castor oil-induced diarrhea), inflammatory diarrhea (induction by prostaglandin E2), and secretory diarrhea (cholera toxin-induced model), resulting from the ability of this monoterpene alcohol to inhibit intestinal motility by means of anticholinergic mechanisms and, consequently, to prevent the accumulation of intestinal fluid and to reduce the secretion of water and chlorides to the intestinal lumen (dos Santos Negreiros et al 2019). In the same study, it was observed that α-terpineol also reduced fluid formation and loss of Cl − ions by interacting directly with GM1 receptors and cholera toxin, thus increasing the uptake of intestinal fluids.…”

Section: Bicas Et Al (2011)mentioning

confidence: 99%

Production, Properties, and Applications of α-Terpineol

Sales

Felipe

Bicas

2020

Food Bioprocess Technol

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α-Terpineol (CAS No. 98-55-5) is a tertiary monoterpenoid alcohol widely and commonly used in the flavors and fragrances industry for its sensory properties. It is present in different natural sources, but its production is mostly based on chemical hydration using α-pinene or turpentine. Moreover, many bioprocesses for the microbial production of α-terpineol via biotransformation of monoterpenes (limonene, αand β-pinenes) are also available in the literature. In addition to its traditional use, αterpineol has also been evaluated in other application fields (e.g., medical), since some biological properties other than aroma, such as antioxidant, anti-inflammatory, antiproliferative, antimicrobial, and analgesic effects, among others, have been attributed to this compound. Therefore, this review presents an original compilation of data regarding the production (extraction directly from nature; chemical synthesis; via biotechnological process), the chemical and biological properties, and the current market and novel applications of α-terpineol to guide further research in this area. Considering the information presented, we believe that αterpineol applications may transcend the flavors and fragrances industry in the future.

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“…The active ingredient of castor oil inducing diarrhea is ricinoleic acid, which produces irritating and in ammatory actions on the intestinal mucosa and leads to the release of prostaglandins [25]. In addition, it also can promote the release of nitric oxide (NO) and the activation of adenylate cyclase, reduce the activity of ATPase pump, so as to reduce the absorption of potassium sodium ions, which leading to the accumulation of electrolytes and water, then diarrhea phenomenon appears [3]. Therefore, the castor oil-induced diarrheal model including secretory and motility diarrhea [25].…”

Section: Discussionmentioning

confidence: 99%

“…Diarrhea is one of the main reasons of morbidity and mortality in developing countries, especially, the death of children [2]. In 2016, it accounted that more than 1300 children die per day and approximately 480,000 die per year [3]. In view of the high incidence of diarrhea and the side effects of Western medicine, the World Health Organization (WHO) is encouraging the search for traditional Chinese antidiarrheal herbs.…”

Section: Introductionmentioning

confidence: 99%

Antidiarrheal Activity of Ethanol Extract of Ophioglossum Vulgatum In Mice And Spasmolytic Effect on Smooth Muscle Contraction of Isolated Jejunum In Rabbits

Zhang¹,

Yang²,

Fang³

et al. 2020

Preprint

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BackgroundOphioglossum vulgatum Linn. (Ophioglossaceae) (OV), which is traditionally used on wounds and burns, enjoys a reputation as the king of medicine in Taiwan. There are few studies on its role in gastrointestinal diseases. Our aim was to assess the antidiarrheal and spasmolytic effect of the ethanol whole plant extract of Ophioglossum vulgatum (EWOV).MethodsStudy was conducted from June 2018 to July 2019. The chemical constituents of EWOV were analyzed by high performance liquid chromatography (HPLC). In vivo, the antidiarrheal activity of EWOV (125, 250 and 500 mg/kg; orally) in castor oil-induced Kun Ming mice was evaluated. In vitro, the effect of EWOV (0.01-10 mg/mL) on the spontaneous contraction of isolated rabbit jejunum smooth muscle was studied. Verapamil was the positive control group in both vivo and vitro studies. The jejunum stripes were pre-contracted by ACh (10-5 M) and KCl (60 mM) which could induce the jejunum spasm. The possible spasmolytic effect was analyzed in the pretreatment of the jejunum preparations with EWOV (0.3, 1 mg/mL) or verapamil (0.03, 0.1 µM) in Ca2+-free and high-K+ (60 mM) solution containing EDTA.ResultsEWOV (250 and 500 mg/kg) exhibited antidiarrheal effect. EWOV (0.01-10 mg/mL) inhibited the spontaneous and ACh/KCl-induced contraction with an EC50 value of 1.46 (0.89-2.04), 1.06 (0.63-1.48) and 0.48 (0.29-0.67), and it shifted the concentration-response curves of CaCl2 to right with decreased in max, similar to verapamil. ConclusionsEWOV has significant antidiarrheal and spasmolytic effect, possibly by mediating calcium channel blocking activity, this provides the pharmacological basis for use in gastrointestinal disorders.

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Antidiarrheal activity of α-terpineol in mice

Cited by 38 publications

References 49 publications

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Production, Properties, and Applications of α-Terpineol

Antidiarrheal Activity of Ethanol Extract of Ophioglossum Vulgatum In Mice And Spasmolytic Effect on Smooth Muscle Contraction of Isolated Jejunum In Rabbits

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