Antidiarrhoeal Activity of Diterpenes of Andrographis paniculata (Kal-Megh) against Escherichia coli Enterotoxin in in vivo Models

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

“…It had been believed that Andrographis paniculata was effective against bacterial dysentery and diarrhea, but how it was accomplished has been unclear up to date. Extracts of Andrographis paniculata have been shown significant antidiarrhoeal activity against Escherichia coli associated diarrhea, 12,13) while andrographolide exhibited similar activity to loperamide the most common antidiarrheal drug. In a double blind study, patients with acute diarrhea and bacillary dysentery responded favorably to Andrographis paniculata.…”

“…5) In Thailand, this plant was selected by the Ministry of Public Health as one of the medicinal plants to be included in "The National List of Essential Drugs A.D. 1999" (List of Herbal Medicinal Products). 6) Extensive research has revealed that Andrographis paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial, such as antiinflammatory, [7][8][9][10][11] antidiarrhoeal, 12,13) antiviral, 14) anti-malarial, 15,16) hepatoprotective, [17][18][19][20][21][22][23][24][25][26][27][28][29] cardiovascular, 30,31) anticancer, [32][33][34][35][36][37][38][39] and immunostimulatory [40][41][42][43][44] activities. On the other hand, male reproductive toxicity 45) and cytotoxicity 46) of this plant have been reported as well.…”

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

“…A. paniculata grows erect to a height of 30 -110 cm with glabrous leaves and white flowers with rose-purple spots on the petals (Sabu, 2006). It grows abundantly in southeastern Asia -India, Pakistan and Indonesia but is cultivated extensively in China, Thailand (Sandberg, 1994), the East and West Indies, and Mauritius (Gupta et al, 1990). Because of its well -known medicinal properties, it is cultivated quite easily.…”

Quality Control Tests on <i>Andrographis paniculata Nees</i> (Family: Acanthaceae) – an Indian ‘Wonder’ Plant Grown in Nigeria

“…In this study we examine the dry aerial parts of the plant obtained in the Institute, using the methods prescribed by WHO [1]. The results obtained are discussed within the context of the Institute's aim of developing a suitable dosage form from Andrographis paniculata -a bitter wonder plant reputed for its immunostimulant and other properties in humans [2][3][4][5][6][7].…”