Antidiarrhoeal activity of Strychnos potatorum seed extract in rats

Biswas, Swati; Murugesan, T.; Sinha, Sagnik; Maiti, Kuntal; Gayen, Jiaur R.; Pal, Mintu; Saha, B. P.

doi:10.1016/s0367-326x(01)00368-9

Cited by 39 publications

(22 citation statements)

References 3 publications

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“…23 The induction of diarrhea by castor oil can also be attributed to the liberation of prostaglandins by colonic cells. 17 Castor oil-induced diarrhea has been shown to be attenuated by many plants extracts such as Strychnos potatorum, 24 Amaranthus spinosus, 25 Ixora coccinea, 26 Pyrenacantha staudtii, 27 Ficus benghalensis, 28 and Matricaria recutita 29 or isolated molecules such as ternatin 30 and piperine. 31 Diarrhea can be also due to the direct or indirect effect of many digestive system products such as bile acids.…”

Section: Discussionmentioning

confidence: 99%

“…41 Indeed, besides their antioxidant activity, these molecules are implicated in the regulation of GIT. 24 Tannins are present in many plants and can denature protein to form the protein tannate complex, which makes the intestinal mucosa more resistant and reduces secretion. 45 Tannins may be responsible for the inhibition of GIT and thereafter the antidiarrheal activity.…”

Section: Figmentioning

confidence: 99%

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Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat

Souli¹,

Sebaï²,

Rtibi³

et al. 2015

Journal of Medicinal Food

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The present study was undertaken to determine whether total and methanol juice extracts of two Tunisian Pomegranate (Punica granatum L.) varieties (Garsi and Gabsi) protect against diarrhea as well as their effects on gastrointestinal transit (GIT) in healthy rats. In this respect, male Wistar rats were used and divided into control-and pomegranatetreated groups. The antidiarrheal activity was evaluated using the castor oil-induced diarrhea method and the GIT was assessed using charcoal meal. Our results showed that total and methanol P. granatum juice extracts produced a significant dose-dependent protection against castor oil-induced diarrhea. Pomegranate extracts and juice also decreased the GIT significantly and dose dependently. Importantly, the Garsi variety appeared to be more effective than the Gabsi variety on these two parameters. These findings suggest that pomegranate extracts have a potent antidiarrheal property in rats confirming their efficiency in the Tunisian traditional medicine.

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Section: Discussionmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat

Souli¹,

Sebaï²,

Rtibi³

et al. 2015

Journal of Medicinal Food

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“…The method of Biswas et al [9] was followed. Non-fasted animals were divided in to four groups of six each.…”

Section: Methodsmentioning

confidence: 99%

Protective effect of Arque-Ajeeb on acute experimental diarrhoea in rats

Khan

Qasmi

et al. 2004

BMC Complement Altern Med

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Background: Diarrhoea is a major health problem for children worldwide, accounting for 5-8 million deaths each year. Arque-Ajeeb (AA) is a compound formulation of Unani medicine. It is reputed for its beneficial effects in the treatment of diarrhoea and cholera, but the claim of its efficacy is yet to be tested. Therefore the present study has been planned to investigate the real efficacy of this drug in rats.

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“…The small intestine was dissected out from the pylorus to the caecum and the total distance travelled by the charcoal plug along the small intestine was estimated for both the control and treated groups. For each group, the results were expressed as percentage of the distance travelled from the pylorus to the caecum [12]. …”

Section: Gastrointestinal Motility Tests (Charcoal Meal)mentioning

confidence: 99%

Detection of Bioflavonoids from Methanol Bark Extracts of Acacia and their Role as Antidiarrhoeal Agents

Raj¹,

Rai²,

Singh³

2017

JAPLR

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Drugs and chemicalsLoperamide was provided as gift sample (Torrent pharmaceuticals, Sikkim, India), Atropine sulphate (Loba chemie, Pvt. Ltd., Mumbai), Activated charcoal and carboxymetyl cellulose sodium (SD fine chem, Mumbai) was purchased. AbstractA variety of healing properties have been attributed to the extract of Acacia catechu Willd of family Fabaceae in folk medicine. It has been used for the treatment of dysentery, diarrhoea, colitis, ulcers, piles, boils, skin eruptions, inflammation, psoriasis, leprosy, anaemia and leucoderma. Objective of the study was to evaluate the antidiarrhoeal activity of methanol bark extract of Acacia catechu willd against experimentally induced diarrhoea by castor oil in albino rats. The methanol bark extract of Acacia catechu (200 and 250mg/kg body weight) was administered orally to two groups of rats (six animals per group) in order to evaluate the activity of the extract against castor oil induced diarrhoea in animal model rats. Two other groups received distilled water (3ml/ kg, p.o.) and Loperamide (3mg/kg, p.o.) as suspension (1% CMC) which served as positive control. The effect of the bark extract on castor oil induced diarrhoea and gastrointestinal transit (charcoal meal test) was assessed respectively. In this study, the methanol bark extract was qualitatively assayed for presence of carbohydrates, glycosides, proteins, phytosterols, flavonoids, alkaloids and tannins. However, the different compounds like catechin and quercetin were confirmed by HPTLC. At the oral doses of 200 and 250 mg/kg body weight, the plant bark extract showed significant (p<0.05) antidiarrhoeal activity compared to the positive control groups in dose-dependent manner. The present study shows that methanol extract of Acacia catechu has significant antidiarhoeal activity. Keywords: Detection of Bioflavonoids from Methanol Bark Extracts of Acacia and their Role as Antidiarrhoeal Agents 2/7Copyright: ©2017 Raj et al.Apparatus: CAMAG HPTLC system equipped with Linomat V applicator, TLC scanner 3, Reprostar 3 and WIN CATS-4 software was used. Collection and authentication of plant materialCertified sample of methanolic bark extract of Acacia catechu was purchased from Herbo Nutra, Mohan garden, Uttam Nagar, New Delhi-59. Phytochemical testingThe phytochemical analysis of the crude methanol bark extract was chemically assayed for presence of carbohydrates, glycosides, proteins, phytosterols, flavonoids, alkaloids, steroids and tannins. Main chemical constituent's catechin and quercetin were estimated through HPTLC. High performance thin layer chromatographyPreliminary phytochemical screening of Acacia catechu was done to identify the chemical constituents and HPTLC finger printing performed for standardization of the drug. CAMAG HPTLC system equipped with Linomat V applicator, TLC scanner 3, Reprostar 3 and WIN CATS-4 software was used to analyse the methanolic bark extract of Acacia catechu. Sample preparation40 mg of methanol bark extracts of Acacia catechu dissolved in 1 ml of HPTLC grade meth...

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Antidiarrhoeal activity of Strychnos potatorum seed extract in rats

Cited by 39 publications

References 3 publications

Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat

Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat

Protective effect of Arque-Ajeeb on acute experimental diarrhoea in rats

Detection of Bioflavonoids from Methanol Bark Extracts of Acacia and their Role as Antidiarrhoeal Agents

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