Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review

Hosseini, Azar; Hosseinzadeh, Hossein

doi:10.1016/j.biopha.2018.01.072

Cited by 118 publications

(88 citation statements)

References 144 publications

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“…Turmeric ( Curcuma longa L) from Zingiberaceae family (Hosseini & Hosseinzadeh, ) is a golden spice. Turmeric is a traditional medicinal plant that is used extensively in domestic use and its application to improve the taste and color and therapeutic properties (Nelson et al, ) without any toxicity in oral administration (Soleimani et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…About 20% to 25% of the adult population worldwide have MetS according to IDF definition, and it is increasing in all over the world (Alberti et al, 2006). Turmeric (Curcuma longa L) from Zingiberaceae family (Hosseini & Hosseinzadeh, 2018) is a golden spice. Turmeric is a traditional medicinal plant that is used extensively in domestic use and its application to improve the taste and color and therapeutic properties (Nelson et al, 2017) without any toxicity in oral administration Abbreviation: ACVD, atherosclerotic cardiovascular diseases; BMI, body mass index; BP, blood pressure; C/EBPα, CCAAT/enhancer binding protein α; CI, confidence intervals; CVD, cardiovascular diseases; DBP, diastolic blood pressure; FFA, free fatty acids; HDL-C, highdensity lipoprotein cholesterol; IDF, International Diabetes Federation; LPL, lipoprotein lipase; MetS, metabolic syndrome; NCEP-ATP III, National Cholesterol Education Program Adult Treatment Panel III; NF-κB, nuclear factor-kappa B; Nrf2, nuclear factor erythroid-2related factor-2; PPAR-γ, peroxisome proliferator-activated receptor-gamma; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-analyses; RCTs, randomized controlled trials; SBP, systolic blood pressure; T2D, type 2 diabetes; TG, triglycerides; WC, waist circumference; WMD, weighted mean differences (Soleimani et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Azhdari

Karandish

Mansoori

2019

Phytotherapy Research

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The finding of studies on the effect of curcumin extract on metabolic factor in patients with metabolic syndrome has had arguable results. This systematic review with meta‐analysis of randomized controlled trials (RCT) aimed to analyze the effect of curcumin/turmeric on metabolic factors in patients with metabolic syndrome. The PICO strategy was used to establish the guiding question of this review. Several databases for RCT were searched until September 2018. Of the 144 articles initially identified, seven trials met the eligibility criteria. A random‐effects model with a mean weight difference (WMD) and a 95% confidence interval was performed for quantitative data synthesis. Pooled estimates of WMD were calculated between intervention and control groups using random‐effects model in the presence of high level of heterogeneity between the studies. The results showed significant improvement of fasting blood glucose (p = 0.01), triglycerides (p < 0.001), high‐density lipoprotein cholesterol (p = 0.003), and diastolic blood pressure (p = 0.007) levels. Curcumin was not associated with a significant change in waist circumference measurement (p = 0.6) and systolic blood pressure level (p = 0.269). Curcumin supplementation improves some components of metabolic syndrome.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Azhdari

Karandish

Mansoori

2019

Phytotherapy Research

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“…The extract or active ingredients of some important plants, such as Curcuma longa (Hosseini & Hosseinzadeh, ), Berberis vulgaris (Mohammadzadeh, Mehri, & Hosseinzadeh, ), Nigella Sativa (Tavakkoli, Ahmadi, Razavi, & Hosseinzadeh, ), Cinnamomum zeylanicum (Dorri, Hashemitabar, & Hosseinzadeh, ), Silybum Marianum (Fanoudi, Alavi, Karimi, & Hosseinzadeh, ), Camellia sinensis (Rameshrad, Razavi, & Hosseinzadeh, ), Vitis vinifera (Tabeshpour, Mehri, Shaebani, & Hosseinzadeh, ), and Crocus sativus (Razavi & Hosseinzadeh, ) have shown the beneficial effects against natural toxins and toxic chemicals. Several reviews exist about the protective effects of GB mostly on dementia and neurological disorders; however, no review has been written about its neutralizing effects against toxins and toxicities so far, and in regard to the various and useful applications and the effects of GB, which have been established up to now, it was necessary to collect and review the papers about the protective effects of this precious plant on toxicities developed via the exposure to natural toxins, chemical toxic agents, and also radiation (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

Omidkhoda

Razavi

Hosseinzadeh

2019

Phytotherapy Research

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Nowadays in our developing and industrial world, humans' health or even their life is threatened by exposure to poisons. In this situation, detecting a protective compound could be helpful and interesting. In the present article, we collected and reviewed all studies, which have been conducted so far about the protective effects of Ginkgo biloba L. (GB), one of the most ancient medicinal tree species, against toxicities induced by chemical toxic agents, natural toxins, and also radiation. In overall, investigations showed that GB exerts the antioxidant, antiinflammatory, antiapoptotic, and antigenotoxicity effects in different toxicities. There are also some special mechanisms about its protective effects against some specific toxic agents, such as acetylcholine esterase inhibition in the aluminium neurotoxicity or membrane‐bond phosphodiesterase activation in the triethyltin toxicity. Ginkgolide A was the most investigated active ingredient of G. biloba leaf extract as a protective compound against toxicities, which had the similar effects of total extract. A few clinical studies have been conducted in this field, which demonstrated the beneficial effects of GB against toxic agents. However, the promising effects of this valuable herbal extract will practically remain useless without carrying out more clinical studies and proving its effects on human beings.

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“…Curcumin is also involved in the increase of insulin in plasma and the decrease of blood glucose in diabetic patients [7,8]. Curcumin was also found to exhibit a protective effect against natural and chemical toxicities [9]. 2 of 19 Structurally, curcumin has two aryl moieties connected by a seven-carbon chain.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway

Castaño

Parween

Pandey

2019

Preprint

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Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have potent wound healing, anti-inflammatory, and anti-carcinogenic activities. While curcuminoids have been studied for many years, not much is known about their effects on steroid metabolism. Since many anti-cancer drugs target enzymes from the steroidogenic pathway, we tested the effect of curcuminoids on cytochrome P450 CYP17A1, CYP21A2, and CYP19A1 enzyme activities. When using 10 µg/ml of curcuminoids, both the 17α-hydroxylase as well as 17,20 lyase activities of CYP17A1 were reduced significantly. On the other hand, only a mild reduction in CYP21A2 activity was observed. Furthermore, CYP19A1 activity was also reduced up to ~20% of control when using 1-100 µg/ml of curcuminoids in a dose-dependent manner. Molecular docking studies confirmed that curcumin could dock into the active sites of CYP17A1, CYP19A1 as well as CYP21A2. In CYP17A1 and CYP19A1, curcumin docked within 2.5 Å of central heme while in CYP21A2 the distance from heme was 3.4 Å, which is still in the same range or lower than distances of bound steroid substrates. These studies suggest that curcuminoids may cause inhibition of steroid metabolism, especially at higher dosages. Also, the recent popularity of turmeric powder as a dilatory supplement needs further evaluation for the effect of curcuminoids on steroid metabolism. Molecular structure of curcuminoids could be modified to generate better lead compounds with inhibitory effects on CYP17A1 and CYP19A1 for potential drugs against prostate cancer and breast cancer.

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Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review

Cited by 118 publications

References 144 publications

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway

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