Antidromic discharge property of meso-accumbens dopaminergic VTA neurons in rats

Addictive neurons

“…Spontaneous spikes are not always observed in VTA DA neurons and bursting is even seldom [24] . The particular feature of SWB concerns the gradual decrease of amplitude of each subsequent spike ( Figure 3A).…”

“…Therefore, also previous studies in rats observed heterogeneities in spike properties and when possible have classified them as type 1 or 2 [24] . The latter has considered those triggering antidromic spikes (in response to electrical stimulation) with a latency of ~13 ms as VTA DA neuron − type 1.…”

“…DSE of vehicle groups is small, but that of TP robust and is blocked by 1 µM AM251 (perhaps in a different cell, since frequencies before the depolarization also differ). DSE was probed with 3 s 60 mV step from HP of −75 mV, and [24] . There is an adaptation of amplitude during the bursts, but note that the same is not always observed at opposite phases of spikes.…”