Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum

Prasad, J. Siva; Shrivastava, Abhishek; Khanna, Ashok; Bhatia, Gitika; Awasthi, Shailendra K.; Narender, Tadigoppula

doi:10.1016/j.phymed.2012.09.001

Cited by 43 publications

(29 citation statements)

References 31 publications

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“…The leaf and seed extracts of C. inophyllum have been revealed to exhibit anti-inflammatory and antioxidant functions (1,2). The seed oil has been demonstrated to promote wound healing and to exhibit antibacterial activity (8).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its traditional use in treating skin problems, including rashes, ulcers, pimples, cuts, wounds and sores, the leaf extracts function as antioxidant, antidyslipidemic and anti-inflammatory agents (1,2). The seeds (tonka beans) of C. cerasiferum Vesque and C. inophyllum contain the highest levels of coumarins (2H-1-benzopyran-2-one) (3), which are phenolic substances composed of fused benzene and α-pyrone rings that are secondary metabolites found in plants, bacteria and fungi.…”

Section: Calophyllum Inophyllum L (C Inophyllum) Of the Familymentioning

confidence: 99%

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Yellow and green pigments from Calophyllumï¿½inophyllum L. seed oil induce cell death in colon and lung cancer cells

et al. 2018

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Abstract. Natural compounds have been candidates for anticancer medicine over the last 20 years. During the process of isolating seed oil from Calophyllum inophyllum L., yellow and green pigments containing multiple compounds with an aromatic structure were identified. High-performance liquid chromatography and nuclear magnetic resonance analysis of these pigments revealed that the compounds present were identical, but the concentration of the compounds was different. Treatment with the pigments was able to induce the death of DLD-1 human colon cancer cells and increase the percentage of the cells in the sub-G 1 and sub-G 2 /M phases in a dose-dependent manner. Additionally, the pigments were able to exhibit cytotoxic activity on A549 and H1975 human non-small cell lung cancer (NSCLC) cell lines at 24 h, with half-maximal inhibitory concentrations (IC 50 ) values of 0.1206 and 0.0676%, respectively for green pigments, and 0.0434 and 0.0501%, respectively for yellow pigments. Furthermore, a decrease in IC 50 value was associated with an increase in the duration of treatment. However, a sharp decrease in IC 50 value of the yellow pigment was observed for H1975 cells at 48 h and for A549 cells at 72 h compared with no change in IC 50 value for the green pigment with time, suggesting that the pigments function and induce cell death differently in the two cell lines. An investigation was performed into the synergistic effect of the green pigment and gefitinib (Iressa ® , ZD1839), which is a selective epidermal growth factor receptor-tyrosine kinase inhibitor to block growth factor-mediated cell proliferation. The combination of the green pigment and gefitinib resulted in an enhancement of the decrease in viability of A549 and H1975 cells compared with treatment with gefitinib alone, which suggested that treatment with the green pigments was able to enhance the sensitivity of NSCLC cells to gefitinib. In conclusion, these pigments may be considered for development as anti-colon cancer agents.

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Section: Discussionmentioning

confidence: 99%

Section: Calophyllum Inophyllum L (C Inophyllum) Of the Familymentioning

confidence: 99%

Yellow and green pigments from Calophyllumï¿½inophyllum L. seed oil induce cell death in colon and lung cancer cells

et al. 2018

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“…The canophyllic acid, amentoflavone and a mixture of calophyllic acid and isocalophyllic acid isolated from C. inophyllum showed dose-dependent lipid-lowering activity under in vivo condition in triton-induced hyperlipidaemia model (Prasad et al 2012).…”

Section: Anti-dyslipidaemic Activitymentioning

confidence: 95%

The Genus Calophyllum: Review of Ethnomedicinal Uses, Phytochemistry and Pharmacology

Gupta

2020

Bioactive Natural Products in Drug Discovery

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The species of genus Calophyllum have been reported for several ethnomedicinal uses in the traditional systems of medicine. The scientific study of the genus Calophyllum revealed that it is a rich source of bioactive secondary metabolites. These phytochemicals have shown a wide range of biological activities. Some of these have reached to the clinical developmental stage. The Calophyllum inophyllum seed oil has been proved to be an acceptable sustainable source of biodiesel. Few species of the genus are endangered and have been included in the red list of threatened species by the IUCN Red List. Owing to the importance of the genus a review of its ethnomedicinal uses, phytochemistry, and pharmacology has been carried out. It will further help to explore the molecular mechanism of phytochemicals for health benefits. KeywordsCoumarins · Xanthones · Antiviral activity · Anti-proliferative activity · HIVinhibitors 5.1

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“…It is also found to have antifeedant activity in some insects [39]. Calophyllum inophyllum : Beneficial Phytochemicals, Their Uses, and Identification DOI: http://dx.doi.org /10.5772/intechopen.86991 Moreover, some compound triterpenoids have been isolated from the C. inophyllum leaves, such as 3β, 23-epoxy-friedelane-28-OIC acid, 3-oxofriedelin-28-OIC acid, epifriedelanol, oleanolic acid [40], 3,4-secofriedelane-3,28-dioic [41], β-amyrin [20], friedelin, canophyllal, canophyllol, and canophyllic acid [4,20,41].…”

Section: Terpenes and Terpenoidsmentioning

confidence: 99%

Calophyllum inophyllum: Beneficial Phytochemicals, Their Uses, and Identification

Susanto¹,

Aparamarta²,

Widjaja³

et al. 2020

Phytochemicals in Human Health

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Calophyllum inophyllum Linn. is one type of mangrove plant. This plant is commonly called nyamplung. This plant is abundant in Indonesia and has many properties that can be exploited from the roots, stems, and leaves to the seeds. All parts of this plant can be useful for human needs. Its oil is generally only used as biodiesel feedstock. The aim of this chapter is to discuss the identification and the uses of phytochemicals contained in C. inophyllum leaves. There are various kinds of phytochemicals contained in C. inophyllum leaves, such as triterpenoids, steroids, flavonoids, coumarins, xanthones, fatty acids, esters, alkenes, ethers, and alicyclic compounds. They have benefits to health, such as anticancer, anti- HIV, antiviral, antitumor, antiinflammatory, antimicrobial, antineoplastic, antiplatelet, antipsychotics, antioxidant, antiaging, antileukemic, antimalarial, anticoagulant, antifeedant, analgesic, photoprotective, molluscicidal, and piscicidal agents. Extraction is a famous method for isolating phytochemicals in C. inophyllum leaves, based on the solvent polarity index.

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Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum

Cited by 43 publications

References 31 publications

Yellow and green pigments from Calophyllumï¿½inophyllum L. seed oil induce cell death in colon and lung cancer cells

Yellow and green pigments from Calophyllumï¿½inophyllum L. seed oil induce cell death in colon and lung cancer cells

The Genus Calophyllum: Review of Ethnomedicinal Uses, Phytochemistry and Pharmacology

Calophyllum inophyllum: Beneficial Phytochemicals, Their Uses, and Identification

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