Antiemetic and Myeloprotective Effects of <i>Rhus verniciflua Stoke</i> in a Cisplatin‐Induced Rat Model

Kim, Hyo-Seon; Kim, Hyeong-Geug; Im, Hwi-Jin; Lee, Jin-Seok; Lee, Sung-Bae; Kim, Wonyong; Lee, Hye Won; Lee, Sam-Keun; Byun, Chang Kyu; Son, Chang‐Gue

doi:10.1155/2017/9830342

Cited by 9 publications

(20 citation statements)

References 37 publications

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“…The histological studies of BM during chemotherapy are poorly reported in the literature. However, similar results were only observed with preventive treatment with L. casei CRL431 (15), or with natural compounds derived from herbal plants, like Ginseng or Rhus verniciflua using different models of immunocompromised hosts (34,35). Moreover, our histological results were correlated with the cell total counts and cell morphologically recognizable counts in both BM and blood.…”

Section: Discussionsupporting

confidence: 81%

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

et al. 2021

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Myelosuppression is the major dose-limiting toxicity of cancer chemotherapy. There have been many attempts to find new strategies that reduce myelosuppression. The dietary supplementation with lactic acid bacteria (LAB) improved respiratory innate immune response and the resistance against respiratory pathogens in immunosupressed hosts. Although LAB viability is an important factor in achieving optimal protective effects, non-viable LAB are capable of stimulating immunity. In this work, we studied the ability of oral preventive administration of viable and non-viable Lactobacillus rhamnosus CRL1505 or L. plantarum CRL1506 (Lr05, Lr05NV, Lp06V or Lp06NV, respectively) to minimize myelosuppressive and immunosuppressive effects derived from chemotherapy. Cyclophosphamide (Cy) impaired steady-state myelopoiesis in lactobacilli-treated and untreated control mice. Lr05V, Lr05NV and Lp06V treatments were the most effective to induce the early recovery of bone marrow (BM) tissue architecture, leukocytes, myeloid, pool mitotic and post-mitotic, peroxidase positive, and Gr-1Low/High cells in BM. We selected the CRL1505 strain for being the one capable of maintaining its myelopoiesis-enhancing properties in its non-viable form. Although the CRL1505 treatments do not modify the Cy ability to induce apoptosis, both increased the incorporation of BrdU in BM cells. Consequently, Lr05NV and Lr05V treatments were able to promote early recovery of LSK cells (Lin-Sca-1+c-Kit+ cells), multipotent progenitors (Lin-Sca-1+c-Kit+CD34+ cells), and myeloid cells (Gr-1+Ly6G+Ly6C- cells) with respect to the untreated Cy control. In addition, these treatments were able to increase the frequency of IL17A-producing innate lymphoid cells in the intestinal lamina propria (IL-17A+RORγt+CD4-NKp46+ cells) after Cy injection. These results were correlated with an increase in the IL-17A serum levels, a GM-CSF high expression and a CXCL12 lower expression in BM. Therefore, both Lr05V and Lr05NV treatments are able to activate beneficially the IL-17A/GM-CSF axis and accelerate the recovery of Cy-induced immunosuppression by increasing BM myeloid precursors. We demonstrated for the first time the beneficial effect of CRL1505 strain on myelopoiesis affected by a chemotherapeutic drug. Furthermore, Lr05NV could be a good and safe resource for reducing chemotherapy-induced leukopenia. The results are a starting point for future research and open up broad prospects for future applications of the immunobiotics.

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Section: Discussionsupporting

confidence: 81%

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

et al. 2021

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“…Several studies have demonstrated the myeloprotective effect of some plant extracts or their active metabolites in chemotherapy. For example, the aqueous extract of R. verniciflua (also from the Anacardiaceae family, such as A. adstringens ) improves the resistance of rats to the adverse effects of chemotherapy in the gastrointestinal tract and the bone marrow [ 5 ]. Similarly, curcumin, a natural polyphenol, increases the tolerance of bone marrow cells to the toxic effects produced by chemotherapy and suppresses the defective hematopoiesis induced by tumor-derived VEGF in a tumor model [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, curcumin, a natural polyphenol extracted from turmeric, attenuates CbPt-induced myelosuppression and increases the survival rate of tumor-bearing animals [ 4 ]. Similarly, treatment of rats with extracts from the lacquer tree ( Rhus verniciflua Stoke) improves the resistance of rats to cisplatin chemotherapy-related adverse effects in the gastrointestinal tract and bone marrow [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Anacardic Acids from Amphipterygium adstringens Confer Cytoprotection against 5-Fluorouracil and Carboplatin Induced Blood Cell Toxicity While Increasing Antitumoral Activity and Survival in an Animal Model of Breast Cancer

et al. 2021

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Amphipterygium adstringens (cuachalalate) contains anacardic acids (AAs) such as 6-pentadecyl salicylic acid (6SA) that show immunomodulatory and antitumor activity with minimal or no secondary adverse effects. By contrast, most chemotherapeutic agents, such as 5-fluorouracil (5-FU) and carboplatin (CbPt), induce myelosuppression and leukopenia. Here, we investigated the myeloprotective and antineoplastic potential of an AA extract or the 6SA as monotherapy or in combination with commonly used chemotherapeutic agents (5-FU and CbPt) to determine the cytoprotective action of 6SA on immune cells. Treatment of Balb/c breast tumor-bearing female mice with an AA mixture or 6SA did not induce the myelosuppression or leukopenia observed with 5-FU and CbPt. The co-administration of AA mixture or isolated 6SA with 5-FU or CbPt reduced the apoptosis of circulating blood cells and bone marrow cells. Treatment of 4T1 breast tumor-bearing mice with the AA mixture or 6SA reduced tumor growth and lung metastasis and increased the survival rate compared with monotherapies. An increased effect was observed in tumor reduction with the combination of 6SA and CbPt. In conclusion, AAs have important myeloprotective and antineoplastic effects, and they can improve the efficiency of chemotherapeutics, thereby protecting the organism against the toxic effects of drugs such as 5-FU and CbPt.

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“…Moreover, 5‐HT acting on epithelial 5‐HT 3 receptor is involved in cisplatin‐induced anorexia and gastric dysmotility . Hence, cisplatin induces the release of 5‐HT from the small intestine (EC cells) and stimulates 5‐HT 3 receptors on gastrointestinal vagal afferents to initiate the vomiting reflex, gastric distension, and delayed gastric emptying . As shown in Figure A, although the serotonin released from intestinal in our experiments was not measured, cisplatin was able to elevate intestinal TPH‐1 activity, which suggesting the production of serotonin may be increased from intestinal EC cells and contributing to gastrointestinal disorders.…”

Section: Discussionmentioning

confidence: 63%

D‐methionine improves cisplatin‐induced anorexia and dyspepsia syndrome by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration

Wong

Lin

Liu

et al. 2020

Neurogastroenterology Motil

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Background:Cisplatin is a widely used antineoplastic drug. However, cisplatin-induced dyspepsia syndromes, including delayed gastric emptying, gastric distension, early satiety, nausea, and vomiting, often force patients to take doses lower than those prescribed or even refuse treatment. D-methionine has an appetite-enhancing effect and alleviates weight loss during cisplatin treatment. Methods:This work established a model of anorexia and dyspepsia symptoms with intraperitoneal injection of cisplatin (5 mg/kg) once a week for three cycles.Presupplementation with or without D-methionine (300 mg/kg) was performed.Orexigenic and anorexigenic hormones (ghrelin, leptin, and glucagon-like peptide-1), tryptophan hydroxylase 1 (TPH1), 5-hydroxytryptamine receptors (5-HT 2C and 5-HT 3 ), and hypothalamic feeding-related peptides were measured by immunohistochemistry staining, enzyme-linked immunosorbent assay, and real-time PCR assay.Key results: Cisplatin administration caused marked decrease in appetite and body weight, promoted adipose and fat tissue atrophy, and delayed gastric emptying and gastric distension, and D-methionine preadministration prior to cisplatin administration significantly ameliorated these side effects. Besides, cisplatin induced an evident increase in serum ghrelin level, TPH1 activity, and 5-HT 3 receptor expression in the intestine and decreased plasma leptin levels and gastric ghrelin mRNA gene expression levels. D-methionine supplementation recovered these changes. The expression of orexigenic neuropeptide Y/ agouti-related peptide and anorexigenic cocaine-and amphetamine-regulated transcript proopiomelanocortin neurons were altered by D-methionine supplementation in cisplatininduced anorexia rats. Conclusions and inferences: D-methionine supplementation prevents cisplatin-in-duced anorexia and dyspepsia syndrome possibly by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration. Therefore, D-methionine can be used as an adjuvant therapy for treating cisplatin-induced adverse effects.

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Antiemetic and Myeloprotective Effects of Rhus verniciflua Stoke in a Cisplatin‐Induced Rat Model

Cited by 9 publications

References 37 publications

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains

Anacardic Acids from Amphipterygium adstringens Confer Cytoprotection against 5-Fluorouracil and Carboplatin Induced Blood Cell Toxicity While Increasing Antitumoral Activity and Survival in an Animal Model of Breast Cancer

D‐methionine improves cisplatin‐induced anorexia and dyspepsia syndrome by attenuating intestinal tryptophan hydroxylase 1 activity and increasing plasma leptin concentration

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