Antiemetic Effect of Droperidol After Ophthalmic Surgery

Iwamoto, Kumiko; Schwartz, Herman

doi:10.1001/archopht.1978.03910060132007

Cited by 41 publications

(10 citation statements)

References 10 publications

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“…However, it is commonly accepted that those patients are particularly predisposed to nausea and vomiting because of intraoperative vagal irritation during the recovery period after strabismus surgery [3]. In addition to being a distress factor to the patient, vomiting can be dangerous during emergence from anesthesia, leading to aspiration, dehydration, electrolyte imbalance, and ophthalmic wound contamination and may result in delay in discharge, especially in children [4, 5]. In this study, the patients undergoing strabismus surgery experienced less postoperative nausea and vomiting with propofol than with halothane/thiopental.…”

Section: Discussionsupporting

confidence: 42%

Comparison of Halothane/Thiopental and Propofol Anesthesia for Strabismus Surgery

Serin

Elibol²,

Sungurtekin³

et al. 1999

Ophthalmologica

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Day case surgery has become a widely accepted practice for many ophthalmological procedures including strabismus surgery. Prompt recovery from anesthesia and minimal postoperative morbidity are especially requested to the anesthesiologists to deal with the high day case surgery burden. The purpose of this study was to compare two anesthesia techniques, halothane/thiopental anesthesia and propofol anesthesia, for patients undergoing monocular strabismus surgery. We studied the level of postoperative consciousness, nausea and vomiting, ocular pain, starting oral intake and activity in 43 patients, ranging from 7 to 41 years of age. A scoring system was used to assess these parameters in the first postoperative 48 h. Although there was not a significant difference in the level of ocular pain, the propofol group had less morbidity in terms of having a better level of consciousness and appetite, less nausea and vomiting and enhanced activity than the halothane/thiopental group. We conclude that propofol anesthesia has significant advantages over halothane/thiopental anesthesia on an outpatient basis for strabismus surgery.

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Section: Discussionsupporting

confidence: 42%

Comparison of Halothane/Thiopental and Propofol Anesthesia for Strabismus Surgery

Serin

Elibol²,

Sungurtekin³

et al. 1999

Ophthalmologica

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“…Harris et al [6] showed that some of this hypotensive effect is present after 60 min, maintaining a lower IOP during surgery. The potent antiemetic antinausea effect may prevent immediate postsurgical complications such as wound dehiscence or prolapse of the iris [5]. These effects were demonstrated in our study, where our results showed significant differences in the intraoperative AC depth and iris bulging in the droperidol group as well as in postoperative wound gaping.…”

Section: Discussionsupporting

confidence: 41%

“…Droperidol, a derivative of butyrophenone haloperidol, has a neuroleptic tranquilizer effect as well as antiemetic and antinausea effects [5]. In addition it was shown that when administered intravenously, it is potent and safe in lowering the IOP [6].…”

Section: Introductionsupporting

confidence: 41%

“…The antiemetic antinausea effect of droperidol in ophthalmic surgery has been known since 1970 [5] and has been confined to the different ophthalmic surgeries as strabismus [5,11,12,13], cataract, pars plana vitrectomy and other surgeries [5]. …”

Section: Discussionmentioning

confidence: 41%

“…It enables the surgeon to control factors that may affect the final surgical outcome, such as arterial blood pressure and intraocular pressure (IOP) [3, 4]. However, postanesthetic nausea and vomiting, encountered frequently after general anesthesia, may cause undesirable complications [5]. …”

Section: Introductionmentioning

confidence: 40%

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The Effects of Droperidol in Perforating Keratoplasty

et al. 2006

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Purpose: To evaluate the intraoperative and postoperative effects of droperidol administered with general anesthesia during perforating keratoplasty. Methods: A prospective, randomized, double-masked clinical trial. Twenty-seven patients undergoing penetrating keratoplasty under general anesthesia were included. Patients were assigned randomly to two groups. Fifteen subjects received droperidol during induction of general anesthesia. Twelve control patients received general anesthesia without droperidol. Results: Droperidol significantly reduced fellow eye intraocular pressure (p < 0.0001). Intraoperative anterior chamber depth was significantly deeper with droperidol (p = 0.0002). Iris bulging was observed in 25% of the control group and 0% with droperidol. There was significantly less postoperative nausea in the droperidol group (p = 0.038). There was less postoperative vomiting in the droperidol group, although the difference was not significant (p = 0.07). Postoperative wound gaping was observed in 2 patients; both of them did not receive droperidol. Conclusions: Droperidol effectively reduces intraoperative and postoperative complications in keratoplasty surgery.

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Drugs for preventing postoperative nausea and vomiting

Carlisle

Stevenson²

2006

Cochrane Database of Systematic Reviews

227

133

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Either nausea or vomiting is reported to affect, at most, 80 out of 100 people after surgery. If all 100 of these people are given one of the listed drugs, about 28 would benefit and 72 would not. Nausea and vomiting are usually less common and, therefore, drugs are less useful. For 100 people, of whom 30 would vomit or feel sick after surgery if given placebo, 10 people would benefit from a drug and 90 would not. Between one to five patients out of every 100 people may experience a mild side effect, such as sedation or headache, when given an antiemetic drug. Collaborative research should focus on determining whether antiemetic drugs cause more severe, probably rare, side effects. Further comparison of the antiemetic effect of one drug versus another is not a research priority.

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Antiemetic Effect of Droperidol After Ophthalmic Surgery

Cited by 41 publications

References 10 publications

Comparison of Halothane/Thiopental and Propofol Anesthesia for Strabismus Surgery

Comparison of Halothane/Thiopental and Propofol Anesthesia for Strabismus Surgery

The Effects of Droperidol in Perforating Keratoplasty

Drugs for preventing postoperative nausea and vomiting

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