2013
DOI: 10.1248/bpb.b12-01079
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Antiemetic Effects of a Potent and Selective Neurokinin-1 Receptor Antagonist, FK886, on Cisplatin- and Apomorphine-Induced Emesis in Dogs

Abstract: showed rapid onset of antiemetic activity after oral administration. At doses of 0.32 mg/kg or more, a pretreatment time of 0.5 h was sufficient for complete inhibition of apomorphine-induced emetic responses. This fast onset after oral administration was supported by pharmacokinetic data, which demonstrated plasma levels of FK886 after oral administration reached levels similar to those 30 min after intravenous administration. These results suggest that FK886 has excellent antiemetic properties in dogs, and t… Show more

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Cited by 4 publications
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“…Session 1 consisted of about 1‐h recordings of GMA and animal behaviors. In this session (control group), after a 15‐min baseline recording of GMA, hypodermic injection of apomorphine (0.1 mg/kg) solved into normal saline (0.01 mg/mL) was given. The GMA and animal behaviors were recorded throughout the entire experimental period for every 15 min.…”
Section: Methodsmentioning
confidence: 99%
“…Session 1 consisted of about 1‐h recordings of GMA and animal behaviors. In this session (control group), after a 15‐min baseline recording of GMA, hypodermic injection of apomorphine (0.1 mg/kg) solved into normal saline (0.01 mg/mL) was given. The GMA and animal behaviors were recorded throughout the entire experimental period for every 15 min.…”
Section: Methodsmentioning
confidence: 99%