Antiemetic effects of sclareol, possibly through 5-HT3 and D2 receptor interaction pathways: In-vivo and in-silico studies

Bappi, Mehedi Hasan; Prottay, Abdullah Al Shamsh; Al-Khafaji, Khattab; Akbor, Md Showkoth; Hossain, Muhammad Kamal; Islam, Md Shahazul; Asha, Afia Ibnath; Medeiros, Cassio Rocha; Tahim, Catarina Martins; Lucetti, Elaine Cristina Pereira; Coutinho, Henrique Douglas Melo; Kamli, Hossam; Islam, Muhammad Torequl

doi:10.1016/j.fct.2023.114068

Cited by 6 publications

(2 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data are analyzed by means of analysis of variance (ANOVA) followed by t -Student–Newman–Keuls’s as post hoc test using the statistical software GraphPad Prism (version 6.5) and experimental groups are compared with the vehicle (control) group. The levels statistical significance ranged with p < 0.05 at 95% confidence intervals ( Bappi et al, 2023a ).…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Haque,

El-Nashar,

Akbor

et al. 2024

Front. Chem.

Self Cite

View full text Add to dashboard Cite

Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in a chick model. Additionally, in silico studies were performed to evaluate the molecular interactions with cyclooxygenase-2 (COX-2).Methods: The tested groups received d-pinitol (12.5, 25, and 50 mg/kg) and the standard drugs celecoxib and ketoprofen (42 mg/kg) via oral gavage prior to formalin injection. Then, the number of licks was counted for the first 10 min, and the paw edema diameter was measured at 60, 90, and 120 min.Results and Discussion: The d-pinitol groups significantly (p < 0.05) reduced the number of paw licks and paw edema diameters, compared to negative control. When d-pinitol was combined with celecoxib, it reduced inflammatory parameters more effectively than the individual groups. The in silico study showed a promising binding capacity of d-pinitol with COX-2. Taken together, d-pinitol exerted anti-inflammatory effects in a dose-dependent manner, possibly through COX-2 interaction pathway.

show abstract

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Haque,

El-Nashar,

Akbor

et al. 2024

Front. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Its 15 mg/kg oral dose attenuated the vomiting refluxes induced by copper sulfate, and sclareol decreased the number of retches and increased delay time. These results were supported through in silico findings suggesting that sclareol binds to 5-HT 3 R and D 1 receptors more strongly than ondansetron and domperidone …”

Section: Nausea and Vomitingmentioning

confidence: 99%

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Akotkar,

Aswar,

Ganeshpurkar

et al. 2024

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

The 5-hydroxytryptamine-3 receptor (5-HT3R), a subtype of serotonin receptor, is a ligand-gated ion channel crucial in mediating fast synaptic transmission in the central and peripheral nervous systems. This receptor significantly influences various neurological activities, encompassing neurotransmission, mood regulation, and cognitive processing; hence, it may serve as an innovative target for neurological disorders. Multiple studies have revealed promising results regarding the beneficial effects of these phytoconstituents and extracts on conditions such as nausea, vomiting, neuropathic pain depression, anxiety, Alzheimer’s disease, cognition, epilepsy, sleep, and dyskinesia via modulation of 5-HT3R in the pathophysiology of neurological disorder. The review delves into a detailed exploration of in silico, in vitro, and in vivo studies and clinical studies that discussed phytoconstituents acting on 5-HT3R and attenuates difficulties in neurological diseases. The diverse mechanisms by which plant-derived phytoconstituents influence 5-HT3R activity offer exciting avenues for developing innovative therapeutic interventions. Besides producing an agonistic or antagonistic effect, some phytoconstituents exert modulatory effects on 5-HT3R activity through multifaceted mechanisms. These include γ-aminobutyric acid and cholinergic neuronal pathways, interactions with neurokinin (NK)-1, NK2, serotonergic, and γ-aminobutyric acid(GABA)ergic systems, dopaminergic influences, and mediation of calcium ions release and inflammatory cascades. Notably, the phytoconstituent’s capacity to reduce oxidative stress has also emerged as a significant factor contributing to their modulatory role. Despite the promising implications, there is currently a dearth of exploration needed to understand the effect of phytochemicals on the 5-HT3R. Comprehensive preclinical and clinical research is of the utmost importance to broaden our knowledge of the potential therapeutic benefits associated with these substances.

show abstract

Anxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches

Prottay,

Emamuzzaman,

Ripu

et al. 2025

Behavioural Brain Research

View full text Add to dashboard Cite

Antiemetic effects of sclareol, possibly through 5-HT3 and D2 receptor interaction pathways: In-vivo and in-silico studies

Cited by 6 publications

References 101 publications

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Anxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches

Contact Info

Product

Resources

About

Antiemetic effects of sclareol, possibly through 5-HT3 and D2 receptor interaction pathways: In-vivo and in-silico studies

Cited by 6 publications

References 101 publications

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Phytoconstituents Targeting the Serotonin 5-HT3 Receptor: Promising Therapeutic Strategies for Neurological Disorders

Anxiogenic-like effects of coumarin, possibly through the GABAkine interaction pathway: Animal studies with in silico approaches

Contact Info

Product

Resources

About

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders