Antiemetic Use for Nausea and Vomiting in Adult Emergency Department Patients: Randomized Controlled Trial Comparing Ondansetron, Metoclopramide, and Placebo

Oligoantiemesis or Inadequate Prescription of Antiemetics in the Emergency Department: A Local and National Perspective

“…It is also possible that some practitioners are not convinced of the efficacy of antiemetic agents in the ED. Although there is evidence that antiemetics are effective in the postoperative and chemotherapy settings, some studies suggest that antiemetics in ED patients with nausea and vomiting are no more effective than placebo (14). However, many of the previous studies may have used suboptimal drug doses, and many of the effects of the antiemetics may have been masked by the simultaneous administration of intravenous fluids.…”

Antiemetische Therapie in der präklinischen Notfallmedizin – Aktuelle Studienlage

“…Eine randomisiert-kontrollierte Multizenterstudie verglich Ondansetron (4 mg), MCP (20 mg) und Placebo bei Patienten mit Übelkeit und Erbrechen in der Notaufnahme, ohne Differenzierung der Ursache [11]. Die Autoren kamen zu dem Ergebnis, dass ▶ keine der verwendeten Substanzen -einschließ lich Placebo - eine signifikant bessere Wirksamkeit erzielen konnte und ▶ die behandelten Patienten aller 3 Gruppen mit der jeweiligen Behandlung zufrieden waren.…”

Drug treatment of adults with nausea and vomiting in primary care

“…We were unable to locate any general practice based studies and found only seven from emergency department practice. [11][12][13][14][15][16][17] Study designs for research in cancer treatment and postoperative nausea and vomiting involve concurrent administration of an antiemetic drug and an emetogenic substance, with measurement of the severity of the ensuing nausea and vomiting. In emergency department based studies, designs involve antiemetic administration followed by measurement of change in severity of the already present symptoms.…”