Antiendometrial Autoantibodies Are Generated in Patients With Endometriosis

Abstract

Our results show that autoantibodies reactive against endometrial antigens are present in patients with endometriosis.

Detection of Antiendometrial Antibodies in Sera of Patients With Endometriosis by Dual‐Colored, Double‐Labeling Immunohistochemical Method and Western Blot

“…These results are inconsistent with those of others [11][12][13][14][15] serum IgG from endometriosis patients but not from fertile women without endometriosis reacted against endometrial antigens with MW of 26, 34, 42, 82, 94, 100, and 120 kDa, which were found exclusively in the endometrium or in implants of endometriosis patients. Gorai et al 14 found that sera from women with endometriosis as well as that from a small number of normal women without endometriosis showed immune reactivity against endometrial antigens with MW of 26, 34, and 42 kDa and that the frequencies of antibodies to these endometrial antigens were significantly higher in endometriosis patients than in normal control women. Rajkumar et al 13 were unable to identify any endometrial antigens with MW <34 kDa to which serum antibodies were present but demonstrated the presence of serum antibodies against a 34 kDa endometrial antigen only in patients with endometriosis.…”

Serum anti-PDIK1L autoantibody as a novel marker for endometriosis

“…This supports a concept that endometriosis possesses an autoimmune nature (9,(11)(12)(13)17). PDIK1L is a protein kinase that will associate with CLP-36-interacting kinase and is widely expressed in many organs and tissues (18).…”

“…Previous studies have suggested that some autoAb-reactions are provoked in patients with endometriosis (9)(10)(11)(12). Accordingly, autoantibodies (autoAbs) as serum biomarkers for the diagnosis of endometriosis have been investigated: anti-a-enolase-autoAb was found to be useful (13); however, the sensitivity of anti-a-enolaseautoAb was just comparable to CA125.…”

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

“…High levels of BLyS result in B lymphocyte production of a plethora of autoantibodies. These autoantibodies include antiendometrial, anti-DNA, antiphospholipid, and antinuclear antibodies [38], and two of them have been identified as antiendometrial autoantibodies against alpha 2-HS glycoprotein and transferrin [39]. Because transferrin functions as an iron transporter in the human body, a high transferrin level in peritoneal fluid could reflect a high iron level in peritoneal fluid in endometriosis patients [39].…”