Antiepileptic drug‐induced lymphoproliferative disorder associated with acquired C1 esterase inhibitor deficiency and angioedema

Schlaifer, Daniel; Arlet, P.; Roque, P Montane de la; Ollier, S.; Abbal, M.; Tallec, Y. Le

doi:10.1111/j.1600-0609.1992.tb01808.x

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“…Angioedema in association with lymhoproliferative disorders was also reported previously with association with acquired C1 esterase inhibitor deficiency in literature. [9] As serum C1 esterase inhibitor was not suggestive, it precludes the association with hereditary angioedema in the index case. Phenytoin was given in a very high dose as suggested by the measured drug level.…”

Section: Discussionmentioning

confidence: 94%

Phenytoin induced life threatening macroglossia in a child

Mondal

Sarkar

Sabui

et al. 2013

Journal of Neurosciences in Rural Practice

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Isolated acquired macroglossia of tongue rarely reported. It occurs due to causes like hereditary angioedema, localized angioedema, etc., Here we describe an 8-year-old boy developing life threatening localized angioedema of tongue due to phenytoin without any association with drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome or pseudolymphoma encountered in rural medical college. Anticonvulsants, that is, phenytoin induced this isolated peculiar complication, which was not described before.

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Section: Discussionmentioning

confidence: 94%