Antiepileptic Drugs in the Treatment of Anxiety Disorders: Role in Therapy

Ameringen, Michael Van; Mancini, Catherine; Patterson, Beth; Truong, Christine

doi:10.3109/9780849382666.012

Cited by 17 publications

(21 citation statements)

References 201 publications

(170 reference statements)

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“…In contrast, the specific anticonvulsants pentobarbital and ethosuximide reduce escape behavior in this test (Commissaris et al 1998b). In this context, it is interesting to note that a relationship between epilepsy and PD in humans has been postulated, an idea supported by clinical studies with antiepileptic compounds in PD (see Andreatini et al 2001;Biraben et al 2001;Schenberg et al 2001;Van Ameringen et al 2004). This was also shown with pregabalin and gabapentin in the present study, compounds that combine anticonvulsant and anxiolytic properties.…”

Section: Distance Traveled (Cm)supporting

confidence: 77%

Defensive-like behaviors induced by ultrasound: further pharmacological characterization in Lister-hooded rats

2007

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Section: Distance Traveled (Cm)supporting

confidence: 77%

Defensive-like behaviors induced by ultrasound: further pharmacological characterization in Lister-hooded rats

2007

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“…In addition to the anticonvulsant action most of the antiepileptic drugs produce anxiolytic activity. 28 Therefore, the present study also evaluated the anxiolytic activity of EAFCF in EPM and OFT. The EPM is etiologically validated and most widely accepted model for screening novel anxiolytic agents in mice 2 as well as in rats.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant and anxiolyic activities of ethyl acetate fraction of Cassia fistula Linn. pods in mice

Kalaiyarasi¹,

Karthika²,

Ragupathi³

2014

Phcog Commn.

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Context: Cassia fistula L. (Leguminacea) is used by Indian and Tanzanian traditional healers for treating various ailments related to the central nervous system. Aims: The present study aimed to evaluate the anticonvulsant and anxiolytic activity of the ethyl acetate fraction obtained from a hydroalcoholic extraction of Cassia fistula pods (EAFCF) and thereby to provide scientific validation for its traditional use. Methods: Preliminary phytochemical analysis and estimation of the flavonoid content of the ethyl acetate fraction was performed. Anticonvulsant activity was assessed by the subcutaneous pentylenetetrazole test (s.c. PTZ test). Anxiolytic activity was assessed by elevated plus maze (EPM) and open field tests (OFT). The sedative and motor toxicity was evaluated by a phenobarbitone induced sleep test and rotarod behavior respectively. Results: Photochemical analysis revealed the presence of a high flavanoid content in the ethyl acetate fraction. Treatment of EAFCF (50 and 100 mg/kg) significantly increased the latency to the onset of minimal clonic seizure and generalized tonic clonic seizure and animals were completely protected from death due to PTZ administration. Administration of EAFCF at the dose of 100 mg/kg markedly increased the open arm entries and time spent in open arm in EPM. In OFT, EAFCF increased the number of central squares crossed and time spent in the central compartment. EAFCF in the doses used in this experiment did not produce sedation or motor toxicity. Conclusion: The results obtained herein clearly indicate the anticonvulsant and anxiolytic activity of EAFCF which may be due to the high flavonoid content. These findings give the scientific support for common use of this plant for treating epilepsy and anxiety.

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“…In fact, almost all AEDs have been successfully trialled in the treatment of panic disorder (Gallinat et al, 2003;Pande et al, 2000;Van Ameringen, Manzini, Pipe, & Benett, 2004;Zwanzger et al, 2003). Some studies defend that these drugs act antipanic ones by reinforcing gabergic transmission (Lauria-Horner & Pohl, 2003;Rupprecht & Zwanger, 2003).…”

Section: Pharmacological Datamentioning

confidence: 99%