We consider the effect of disorder on the tight-binding Hamiltonians with a flat band and derive a common mathematical formulation of the average density of states and inverse participation ratio applicable for a wide range of them. The system information in the formulation appears through a single parameter which plays an important role in search of the critical points for disorder driven transitions in flat bands [1]. In weak disorder regime, the formulation indicates an insensitivity of the statistical measures to disorder strength, thus confirming the numerical results obtained by our as well as previous studies.