Antifertility Potential of n-Butanol and Ethyl Acetate Extracts of Penicillium oxalicum OM282858 in Male Albino Rats as Biological Control Agents

Taha, Ayat; Gouda, Shaymaa A.

doi:10.18006/2022.10(6).1354.1365

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…These findings align with the previous study of De Franciscis et al (2015). Monitoring sperm count and motility are crucial criteria for determining an animal's fertility (Taha & Soliman, 2019;Taha & Gouda, 2022). The number of sperm abnormalities was significantly higher in the Cdpolluted water group (Group B) than that recorded in the normal control group (Group A) and significantly lower in the fungal biosorption water treatment group (Table 7).…”

Section: Effect Of Fungal Treatment On Semen Parameters In Male Albin...supporting

confidence: 90%

Biosorption of Cadmium from Polluted Waters Using Dead Biomass of the Fungus Alternaria tenuissima and its Toxicological Effects on Male Albino Rats

Gouda et al.

2023

Egypt. J. of Aquatic Biolo. and Fish.

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It is important to find and identify more biological adsorbents that can effectively remove metals from water instead of using the traditional approach. In the present study, a fungal strain resistant to cadmium was isolated from polluted sites. It was identified morphologically and molecularly as Alternaria tenuissima, with an accession number of OQ691600. Heat inactivated biomass of A. tenuissima was evaluated for cadmium (Cd) biosorption. The biosorption process was conducted at a temperature of 28±2°C to remove Cd from water at an initial concentration of 92 mg/ L, under different conditions, such as pH (4-6), biosorbent dose (1-3 g/L), and sorption time (15-60 min). The obtained results demonstrated that the dead biomass of A. tenuissima effectively removed Cd, with maximum significant biosorption efficiency of 99.95±0.003% and capacity of 92.33±0.21 mg/g, which were achieved at a pH value of 6 for 30 min and a biosorbent dose of 1 g/L. Fourier transform-infrared (FT-IR) spectroscopy analysis revealed changes in the functional groups present on the surface of A. tenuissima biomass through the biosorption process. Following the biosorption process, three groups of male albino rats were used. The negative control group received only double-distilled water through oral administration. The Cd-polluted water group received a Cd aqueous solution (92 mg/L) through oral administration for 30 days. The treatment group received Cd aqueous solution (92 mg/L) through oral administration after treatment with A. tenuissima as the biosorbent material for a period of 30 days. The results showed that Cd caused a significant drop in weight gain and testicular index weight, as well as total protein, albumin, semen count, and motility. There were significant increases in abnormal sperm, the spleen, and brain index weight, as well as biochemical parameters, including aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and uric acid, showed notable changes. The liver, kidney, testis, and epididymis of male albino rats showed several histopathological changes along with bioaccumulation of Cd traces in liver and kidney tissues. However, in the treatment group, all these findings were noticeably improved. Based on our findings, the dead biomass of A. tenuissima has the potential to be a very effective biosorbent for removing cadmium from water, without causing any hazardous effects on animals.

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Section: Effect Of Fungal Treatment On Semen Parameters In Male Albin...supporting

confidence: 90%

Biosorption of Cadmium from Polluted Waters Using Dead Biomass of the Fungus Alternaria tenuissima and its Toxicological Effects on Male Albino Rats

Gouda et al.

2023

Egypt. J. of Aquatic Biolo. and Fish.

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“…Measuring the fertilizing potential of sperm was one way to get a sense of whether an animal was fertile or not, and both the number and moility of its sperm were crucial considerations (Mahmoud et al, 2018;Taha & Soliman, 2019;Taha & Gouda, 2022). As can be shown in Figs.…”

Section: Effect Of Lead Removal Using T Stipitatus On Semen Quality F...mentioning

confidence: 99%

Bioremoval of Lead from Polluted Waters Using the Fungus Talaromyces stipitatus and Its Impact on Male Albino Rats

Taha et al.

2023

Egypt. J. of Aquatic Biolo. and Fish.

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Lead (Pb) is one of the most serious environmental pollutants due to its accumulation in soil and water, which causes serious problems for human health and the environment. Biosorption using dead microbial biomass represents one of the most innovative, economically feasible, and environmentally safe tools for removing heavy metals. Therefore, the present study focused on removing lead using Talaromyces stipitatus as a dead fungal biomass and evaluating its impact on animal toxicity. Lead-tolerant fungi were isolated from polluted sites, and T. stipitatus was chosen for the biosorption investigation based on its distinctive characteristics and identified according to its morphological and molecular characteristics then submitted to the GenBank database under accession number OQ691598. The biosorption capacity and efficiency of Pb were evaluated at 28±2°C with various parameters, which included pH, contact time and biomass concentration. Our findings showed that the highest significant biosorption capacity (56.10 mg/g) and efficiency (96.62%) for lead removal from aqueous solutions (lead initial concentration, 58 mg/L) were achieved at pH 6 and 30 minutes of contact time, with a biomass content of 1 g/L. Three groups of male albino rats were used after the biosorption study; the negative control group orally received double-distilled water only; the positive control group orally received Pb aqueous solution (58 mg/L) for 30 days, and the treatment group orally received Pb aqueous solution (58 mg/L) after being treated with T. stipitatus as biosorbent material for 30 days. The findings revealed that Pb induced a significant decrease in weight gain and relative weights of liver and testis, sperm count and motility, as well as serum total protein and albumin levels, but it induced a significant increase in relative weights of lung, brain, and prostate, serum aspartate aminotransferase and alanine aminotransferase activities, serum urea, creatinine, and uric acid levels, sperm abnormalities, and bioaccumulation of Pb traces in liver and kidney tissues with several histopathological changes in the liver, kidney, testis and epididymis of male albino rats. The treatment group showed considerable improvements in each of the aforementioned results in animals. These findings suggest that T. stipitatus is capable of removing lead from polluted waters without posing any health risks to animals. To the best of our knowledge, no previous report has documented the use of T. stipitatus for lead removal and its effect on animal toxicity.

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Evaluating the effects of quinestrol on the reproductive organs of the Nile rat ( Arvicanthis niloticus ) for use in the rat control

Omar,

El-Tantawi,

Soliman

et al. 2023

Egyptian Journal of Basic and Applied Sciences

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Antifertility Potential of n-Butanol and Ethyl Acetate Extracts of Penicillium oxalicum OM282858 in Male Albino Rats as Biological Control Agents

Cited by 4 publications

References 37 publications

Biosorption of Cadmium from Polluted Waters Using Dead Biomass of the Fungus Alternaria tenuissima and its Toxicological Effects on Male Albino Rats

Biosorption of Cadmium from Polluted Waters Using Dead Biomass of the Fungus Alternaria tenuissima and its Toxicological Effects on Male Albino Rats

Bioremoval of Lead from Polluted Waters Using the Fungus Talaromyces stipitatus and Its Impact on Male Albino Rats

Evaluating the effects of quinestrol on the reproductive organs of the Nile rat ( Arvicanthis niloticus ) for use in the rat control

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