Antifibrinolytics Reduce Blood Loss in Adult Spinal Deformity Surgery: A Prospective Randomized Controlled Trial

Goz, Vadim; Slobodyanyuk, Kseniya; Cheriyan, Thomas; Schwab, Frank J.; Verma, Kushagra; Hoelscher, Christian; Peters, Austin; Huncke, Tessa; Lonner, Baron S.; Errico, Thomas J.

doi:10.1016/j.spinee.2013.07.032

Cited by 4 publications

(2 citation statements)

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“…There is growing evidence for the well tolerated and beneficial use of tranexamic acid to reduce perioperative blood loss, allogeneic blood transfusions and associated costs in major orthopaedic surgery such as total hip or knee arthroplasty, and spine surgery. [313][314][315][316][317][318][319][320][321][322][323][324][325][326] However, tranexamic acid is not recommended in patients with hypersensitivity or allergy to the drug, history of venous or arterial thrombosis, or thrombophilia, cardiovascular disease, acute renal failure or subarachnoid haemorrhage, or in patients with a history of seizures or epilepsy. 327 There is emerging evidence that topical administration of tranexamic acid may be beneficial in reducing the rate of blood transfusions in both total hip replacement and total knee replacement surgery.…”

Section: Antifibrinolyticsmentioning

confidence: 99%

Management of severe perioperative bleeding

Kozek‐Langenecker

Ahmed

Afshari

et al. 2017

European Journal of Anaesthesiology

693

316

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: The management of perioperative bleeding involves multiple assessments and strategies to ensure appropriate patient care. Initially, it is important to identify those patients with an increased risk of perioperative bleeding. Next, strategies should be employed to correct preoperative anaemia and to stabilise macrocirculation and microcirculation to optimise the patient's tolerance to bleeding. Finally, targeted interventions should be used to reduce intraoperative and postoperative bleeding, and so prevent subsequent morbidity and mortality. The objective of these updated guidelines is to provide healthcare professionals with an overview of the most recent evidence to help ensure improved clinical management of patients. For this update, electronic databases were searched without language restrictions from 2011 or 2012 (depending on the search) until 2015. These searches produced 18 334 articles. All articles were assessed and the existing 2013 guidelines were revised to take account of new evidence. This update includes revisions to existing recommendations with respect to the wording, or changes in the grade of recommendation, and also the addition of new recommendations. The final draft guideline was posted on the European Society of Anaesthesiology website for four weeks for review. All comments were collated and the guidelines were amended as appropriate. This publication reflects the output of this work.

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Section: Antifibrinolyticsmentioning

confidence: 99%

Management of severe perioperative bleeding

Kozek‐Langenecker

Ahmed

Afshari

et al. 2017

European Journal of Anaesthesiology

693

316

View full text Add to dashboard Cite

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“…19,20 Overall, orthopedic studies have demonstrated the efficacy of TXA and EACA over placebo in relation to blood loss. 14,[21][22][23][24][25][26][27][28][29][30] In two recent Cochrane reviews TXA was noted to be more efficacious than EACA at reducing total blood loss. 9,14 Numerous studies in both the adult and pediatric literature have shown reduced blood loss utilizing these medications.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Two Different Dosing Protocols for Tranexamic Acid in Posterior Spinal Fusion for Spinal Deformity: A Prospective, Randomized Trial

et al. 2015

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Osteotomies in the treatment of spinal deformities: indications, classification, and surgical planning

Diebo

Liu

Lafage

et al. 2014

Eur J Orthop Surg Traumatol

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The surgical treatment of adult spinal deformity has been shown to offer superior clinical and radiographic outcomes compared with nonoperative approaches; furthermore, osteotomies are increasingly applied for treating spinal deformities. Establishing a plan for a patient suffering from marked spinal deformity is a matter of consideration of certain radiographic parameters which correlate with health-related quality of life scores, adherence to consistent principles of alignment and established formulas, and selecting the appropriate osteotomies. This is a review of the most recent work on vertebral osteotomies and includes a summary of a systematic and anatomically based osteotomy classification. A universal classification will facilitate communication, standardize outcomes research, and establish a framework upon which indications can be properly studied and described. Ongoing multicenter collaboration is certain to drive a more evidence-based approach to the complex clinical scenarios of patients suffering from spinal deformity.

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Antifibrinolytics Reduce Blood Loss in Adult Spinal Deformity Surgery: A Prospective Randomized Controlled Trial

Cited by 4 publications

References 0 publications

Management of severe perioperative bleeding

Management of severe perioperative bleeding

A Comparison of Two Different Dosing Protocols for Tranexamic Acid in Posterior Spinal Fusion for Spinal Deformity: A Prospective, Randomized Trial

Osteotomies in the treatment of spinal deformities: indications, classification, and surgical planning

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