Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells

Lee, Mi Kyeong; Yang, Hyun-Jin; Yoon, Jeong Seon; Jeong, Eun Ju; Kim, Do Yoon; Ha, Na Ry; Sung, Sang Hyun; Kim, Young Choong

doi:10.1007/s12272-001-1239-9

Cited by 21 publications

(9 citation statements)

References 24 publications

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“…This indigenous plant has been used as a Korean traditional medicine for the treatment of hypertension, hematemesis, epistaxis, and hemorrhoids [1]. Diterpenoids [2], essential oils [3], lignans [4], and flavonoids [5] were isolated from this plant and some of them showed neuroprotective [4], antiaggregative [6], antifibrotic [2], and fungitoxic [3] activities. In the course of our continuing search for biologically active compounds from natural Korean medicinal sources, we investigated MeOH extracts of the leaves of T. orientalis.…”

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confidence: 99%

Three New Diterpenoids from the Leaves ofThuja orientalis

2012

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Three new diterpenoids, 18-formyloxy-8β-hydroxysandaracopimar-15-ene (1), 15(R)-n-butoxypinusolidic acid (2), and 15,16-dihydro-15,16-dimethoxylambertianic acid (3), along with twelve known compounds (4-15) were isolated from MeOH extracts of leaves of Thuja orientalis L. The structures of the three new compounds were elucidated on the basis of spectroscopic analyses, including extensive 2D-NMR data. The absolute stereochemistry of compound 2 was clarified by a CD spectroscopic study. The isolated compounds were evaluated for cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the sulforhodamin B (SRB) bioassay.

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confidence: 99%

Three New Diterpenoids from the Leaves ofThuja orientalis

2012

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“…Cell viability was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay [5].…”

Section: Measurement Of Cell Viabilitymentioning

confidence: 99%

“…In relation to liver fibrosis, a diverse array of natural products including flavonoids, alkaloids and terpenoids have been suggested to have antifibrotic activity [5][6][7][8].There is therefore a growing interest in searching for antifibrotic compounds from natural products with lower adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells

et al. 2010

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The CHCl(3) fraction of Cnidium monnieri fruits significantly inhibited the proliferation of hepatic stellate cells in an in-vitro assay system employing HSC-T6 hepatic stellate cell lines. Activity-guided fractionation of the CHCl(3) fraction of C. monnieri led to the isolation of ten coumarins: osthol (1), meranzin (2), auraptenol (3), meranzin hydrate (4), 7-hydroxy-8-methoxy coumarin (5), imperatorin (6), xanthotoxol (7), xanthotoxin (8), bergapten (9) and isopimpinellin (10). Of these, compounds 1 and 6 significantly inhibited proliferation of HSCs in a time- and concentration-dependent manner. In addition, compounds 1 and 6 significantly reduced collagen content in HSC-T6 cells.

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“…Napthoquinone derivatives of phlomisoic acid methyl ether ( 4 ) were found to exhibite cytotoxic activity against human tumor cells . Oleoresin of P. sibirica and Biota orientalis yielded the product of oxidative metabolism at the C‐16 atom of labdanoid core, pinusolide ( 5 ) . Pinusolide attenuated the neurotoxic effect of staurosporine in primary cultures of rat cortical cells .…”

Section: Introductionmentioning

confidence: 99%

Furanolabdanoid–based 1,2,4‐oxadiazoles: Synthesis and cytotoxic activity

et al. 2016

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Several 15,16-epoxy-8,13,14-labdatriene derivatives modified at the C-16 position with a 1,2,4-oxadiazole ring with various substituent in the 5-th position, were obtained via multistep synthesis from 16-formyl derivatives of natural diterpenoid lambertianic acid. The cytotoxicity of furanolabdanoid-based 1,2,4oxadiazoles was evaluated against human cancer cells (CEM-13, MT-4, U-937, MCF-7, MDA-MB-231, MEL-8) using the conventional MTT assays. All the tested diterpenoid-oxadiazole hybrids displayed better cytotoxic activity then lambertianic acid. The activity and selectivity to the cell line increased even further in the compounds containing a chloromethyl substituent in the 5th position of the 1,2,4-oxadiazole ring. Two of the synthesized compounds exhibited high cytotoxic activity against lymphoblastoid cell line CEM-13 (GI 50 0.08-0.34 mM), which was higher that than of the comparative drug Doxorubicin. The antitumor mechanism may be related to apoptosis induction in U-937, MCF-7, and CEM-13 cells.[a] Dr.

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Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells

Cited by 21 publications

References 24 publications

Three New Diterpenoids from the Leaves ofThuja orientalis

Three New Diterpenoids from the Leaves ofThuja orientalis

Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells

Furanolabdanoid–based 1,2,4‐oxadiazoles: Synthesis and cytotoxic activity

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