Antifibrotic candidates of Selenium nanoparticles and selenium in the experimental model

Abstract

This research was designed to compare the efficacy of selenium in nanoscale (SeNPs) with its free form (Se) against liver fibrosis induced by thioacetamide (TAA) in rats. In a completely randomized design, 60 adult female rats were distributed as: Group (1) control (received saline) and other three groups received TAA to induce liver fibrosis (100 mg/kg b.wt of three times a week for 6 weeks). Fifteen rats were termed TAA (Group 2). Rats in group (3) were simultaneously administered SeNPs (0.48 mg/kg/b.wt) orally (TAA+SeNPs). Rats in group (4) were simultaneously administered Se (0.48 mg/kg/b.wt) orally (TAA+Se). TAA injection enhanced liver enzymes activity, oxidative stress markers and inflammatory mediators, while suppressed the activity of the antioxidant enzymes activity versus the control group. SeNPs as well as Se supplementation blunted liver enzymes activity, oxidative stress indicators and inflammatory intermediates, while potentiated the activity of the antioxidant enzymes relative to TAA group. Histological investigation of liver tissue appreciated the biochemical findings. Aforementioned data clearly indicate that the mitigation of oxidative stress and inflammation may be the probable mechanisms by which SeNPs or Se can offer their antifibrotic action. Worth mentioning, SeNPs showed superior effect above Se in its free form in this respect.

Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro

“…Hirst and coworkers also investigated CeO 2 NP (3–5 nm) and CCl 4 -induced liver fibrosis in mice and found that CeO 2 NP reduced oxidative stress damage markers to levels comparable to N -acetylcysteine [ 19 ]. Other NP types, such as TiO 2 NP, silicon dioxide NP [ 31 ], zinc oxide NP [ 32 ] and selenium NP [ 33 ], have previously been shown to inhibit liver fibrosis, demonstrating that NPs are indeed capable of attenuating the fibrotic liver phenotype.…”

Recent advances in the therapeutic applications of selenium nanoparticles

“…The findings revealed that SeNPs and Se intake reduced the action of liver enzymes, oxidative stress markers, and inflammatory mediators while increasing the activity of enzymes as compared to the thioacetamide group. The reduction of oxidative stress and inflammation could be the processes via which SeNPs or Se exert antifibrotic effects [ 39 ].…”