Antifibrotic Effect of Curcumin on Thioacetamide Induced Liver Fibrosis

Abdou, Suzan E.; Taha, Nabil M.; Mandour, Abd El-Wahab; Lebda, Mohamed A.; Hofi, Hanaa R. El; El-Morshedy, A. M.

doi:10.5455/ajvs.179458

Cited by 7 publications

(9 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histopathologically, severe alterations of liver structure with fibrogenesis processes were noted. Similar observations were detected in many experimental studies on TAA induced relative influences (Al-Attar, 2011, Al-Attar, 2012, Mustafa et al, 2013, Ali et al, 2014, Abdou et al, 2015, Al-Attar and Shawush, 2015, Wang et al, 2015).…”

Section: Discussionsupporting

confidence: 88%

“…The hepatic toxic chemical TAA has been widely used in the study of the underlying mechanisms of hepatic fibrogenesis and the therapeutic effects of potential antifibrosis drugs. Additionally, many experimental investigations showed that TAA induced hepatic fibrosis and cirrhosis in rats and mice (Al-Attar, 2011, Al-Attar, 2012, Ali et al, 2014, Abdou et al, 2015, Al-Attar and Shawush, 2015; Meng et al, 2015, Wang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Plants are a rich source of bioactive components that have desirable health benefits and are traditionally known to be useful for prevention of chronic diseases (Yogalakshmi et al, 2010). Herbal medicines have been reported to show protective effects from liver fibrosis and injury (Hsieh et al, 2008, Yuan et al, 2008, Al-Attar, 2012, Saravanan et al, 2013, Ali et al, 2014, Abdou et al, 2015, Al-Attar and Shawush, 2015). Olea oleaster corresponds to Olea europaea subsp.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Olea oleaster and Juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice

Al-Attar

Al-Robai

Almalki

2016

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

The effect of Olea oleaster and Juniperus procera leaves extracts and their combination on thioacetamide (TAA)-induced hepatic cirrhosis were investigated in male albino mice. One hundred sixty mice were used in this study and were randomly distributed into eight groups of 20 each. Mice of group 1 served as controls. Mice of group 2 were treated with TAA. Mice of group 3 were exposed to TAA and supplemented with O. oleaster leaves extracts. Mice of group 4 were treated with TAA and supplemented with J. procera leaves extracts. Mice of group 5 were subjected to TAA and supplemented with O. oleaster and J. procera leaves extracts. Mice of groups 6, 7 and 8 were supplemented with O. oleaster, J. procera, and O. oleaster and J. procera leaves extracts respectively. Administration of TAA for six and twelve weeks resulted in a decline in body weight gain and increased the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin. Histopathological evaluations of hepatic sections from mice treated with TAA showed severe alterations including increase of fibrogenesis processes with structural damage. Treatment of mice with these extracts showed a pronounced attenuation in TAA induced hepatic cirrhosis associated with physiological and histopathological alterations. Finally, this study suggests that the supplementation of these extracts may act as antioxidant agents and could be an excellent adjuvant support in the therapy of hepatic cirrhosis.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Olea oleaster and Juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice

Al-Attar

Al-Robai

Almalki

2016

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…The present study showed that the administration of TAA for three and six weeks induced an elevation in the levels of serum ALT, AST, ALP, GGT and total bilirubin in rats, since necrosis or membrane damage releases these enzymes into circulation, which agrees with the previously reported results ( Kew, 2000 ). Moreover, many investigations showed that these parameters were significantly enhanced in experimental animals exposed to TAA ( Al-Attar, 2011 , Al-Attar, 2012 , Ali et al, 2014 , Kim et al, 2014 , Zargar, 2014 , Abdou et al, 2015 , Al-Attar and Shawush, 2015 , Al-Attar et al, 2016 , Luo et al, 2015 ). Damage of hepatocytes is reflected by an elevation in the levels of hepato specific enzymes (ALT, AST, and ALP), these are cytoplasmic in lection and are released into circulation after cellular damage ( Sallie et al, 1991 ).…”

Section: Discussionmentioning

confidence: 99%

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Al-Attar

Al-Rethea

2017

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

The current study was designed to investigate the possible protective effect of omega-3 fatty acids from fish oil on hepatic fibrosis induced by thioacetamide (TAA) in male rats. The experimental animals were divided into four groups. The first group was received saline solution and served as control. The second group was given 250 mg/kg body weight of TAA. The third group was treated with omega-3 fatty acids and TAA. The fourth group was given saline solution and supplemented with omega-3 fatty acids. Treatment of rats with TAA for three and six weeks resulted in a significant decrease in body weight gain, while the value of liver/body weight ratio was statistically increased. Furthermore, the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and total bilirubin were significantly increased. After three weeks of exposure to only TAA, liver sections showed an abnormal morphology characterized by noticeable fibrosis with the extracellular matrix collagen contents and damage of liver cells' structure. Liver sections from rats treated with only TAA for six weeks revealed an obvious increase in extracellular matrix collagen content and bridging fibrosis. Treating TAA-intoxicated rats with omega-3 fatty acids significantly attenuated the severe physiological and histopathological changes. Finally, the present investigation suggests that omega-3 fatty acids could act against hepatic fibrosis induced by TAA due to its antioxidant properties, thus supporting its use in hepatic fibrosis therapy.

show abstract

“…All rats were allowed two weeks as acclimatized period before the beginning of study for adaptation and ensure normal growth and behavior. Rats were randomly separated into 6 groups (10 rats each): control group: received 0.2 ml of distilled water/ 100 g bwt/ day orally (vehicle of TAA and ALA) using a stomach tube three times a week, TAA-treated group: received intraperitoneal (IP) injection of TAA (250 mg/kg bwt dissolved in distilled water) three times a week according to Abdou et al (2015). ALA-treated group: received ALA (100 mg/kg bwt/day) orally using a stomach tube three times a week according to Yousef et al, (2015).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Potential Ameliorative Effects of Alpha Lipoic Acid and Silymarin on Thioacetamide-Induced Hepatic Damage in Rats

Salama¹,

Oda²,

Khafaga³

et al. 2017

AJVS

View full text Add to dashboard Cite

Key words:liver, thioacetamide, silymarin, alpha lipoic acid, rats.The present study was designed to study the ameliorative role of alpha lipoic acid (ALA) and silymarin (SIL) against thioacetamide (TAA)-induced hepatic damage. Sixty male albino rats were randomly separated into 6 groups (n=10); control group, TAA-treated group: received intraperitoneal injection of TAA 250 mg/kg bwt/day three times a week, ALAtreated group: received ALA 100 mg/kg bwt/day) orally three times a week, SIL-treated group: received SIL 100 mg/kg bwt/day orally three times a week, TAA+ALA-treated group, and TAA+SIL-treated group at the same previous doses and routes for ten weeks. Results showed that TAA induced a significant elevation in total and direct bilirubin, total cholesterol and triglycerides levels and serum liver enzymes after four and ten weeks of the treatments. While the serum levels of total proteins, albumin and high density lipoproteincholesterol revealed a significant decrease. TAA injection resulted in an increase in the hepatic lipid peroxidation and decreased levels of antioxidant biomarker. Histopathologically, TAA revealed marked degenerative, necrotic and fibrotic alterations in the liver, particularly during ten weeks post-treatment. ALA and SIL-treatment ameliorated TAA-induced oxidative damage, alterations in the liver function tests and liver histopathology. However, ALA demonstrated better hepatic protection against TAAinduced liver damage as compared to SIL. The study clearly concluded that ALA has more powerful antioxidant properties than SIL.

show abstract

Antifibrotic Effect of Curcumin on Thioacetamide Induced Liver Fibrosis

Cited by 7 publications

References 48 publications

Effect of Olea oleaster and Juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice

Effect of Olea oleaster and Juniperus procera leaves extracts on thioacetamide induced hepatic cirrhosis in male albino mice

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Potential Ameliorative Effects of Alpha Lipoic Acid and Silymarin on Thioacetamide-Induced Hepatic Damage in Rats

Contact Info

Product

Resources

About