Antifibrotic mechanism of deferoxamine in concanavalin A induced-liver fibrosis: Impact on interferon therapy

Darwish, Samar F.; El-Bakly, Wesam M.; El-Naga, Reem N.; Awad, Azza S.; El‐Demerdash, Ebtehal

doi:10.1016/j.bcp.2015.09.001

Cited by 31 publications

(18 citation statements)

References 57 publications

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“…In the present study, ConA significantly lowered the liver tissue content of GSH and activities of SOD and CAT while it induced a significant increase in liver MDA content. These results are in accordance with previous studies (22,35). Apocynin pretreatment significantly counteracted ConA-induced oxidative stress in accordance with earlier studies performed in the heart and vascular tissue of rats (36,37).…”

Section: Discussionsupporting

confidence: 83%

“…Liver fibrosis is characterized by both quantitative and qualitative alteration of hepatic ECM, as a consequence of HSCs activation towards myofibroblastlike cells. This is characterized by increased liver content of α-SMA as a marker for activated HSCs, and accumulation of ECM mainly collagen, which is stimulated by the multifactorial growth factor TGF-β (22). In the present study, histopathological examination of collagen fibers using Masson's trichrome stain revealed severe fibroblastic cells proliferation in liver samples of ConA intoxicated group as well as elevated hydroxyproline content.…”

Section: Discussionmentioning

confidence: 72%

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The potential antifibrotic impact of apocynin and alpha-lipoic acid in concanavalin A-induced liver fibrosis in rats: Role of NADPH oxidases 1 and 4

Fayed

El-Naga

Akool

et al. 2018

DD&T

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 72%

The potential antifibrotic impact of apocynin and alpha-lipoic acid in concanavalin A-induced liver fibrosis in rats: Role of NADPH oxidases 1 and 4

Fayed

El-Naga

Akool

et al. 2018

DD&T

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“…Similar kind of attenuation was observed by Shoeib et al and Leite et al [58,59]. On the other hand, tissue iron is highly monitored and maintained by heme oxygenase (HO) which is often degraded by foreign harmful stimuli and initiate several types of dysfunctions like iron overload, hypertrophy and apoptosis ( Figures 7A-7D) [10,60]. Our histology showed that massive amount of iron has been observed in both liver and kidney ( Figures 8D and 11D) which were normalized by 1% Syzygium cumini seed supplement.…”

Section: Discussionsupporting

confidence: 69%

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

Sagor¹,

Mohib²,

Tabassum³

et al. 2016

J Drug Metab Toxicol

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Nowadays, the drug induced organ damage has increased drastically. Similarly, number of Adverse Drug Reactions (ADR) is on the rise. Unwanted and harmful effects of a drug have been a good reason for early withdrawal of a good molecule from the market or clinical trial. In the present study, we have investigated the preventive role of Syzygium cumini against Acetaminophen induced organ damage. In this study, four different groups of rats were evaluated. Group A serves as a control group, Group B serves as control + Syzygium cumini group, Group C serves as disease group and Group D serves as disease + treatment group. Only two groups have been treated and exposed to an overdose of acetaminophen. However, liver and kidney markers like Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Creatinin and Uric acid (UA) were measured respectively. Moreover, oxidative stress markers such as Malondialdehyde (MDA), Nitric Oxide (NO) and Advanced Oxidation Protein Product (AOPP) were found higher in acetaminophen overdose rats compared to control rats. Furthermore, antioxidant enzymes like Catalase (CAT), Superoxide Dismutase (SOD) and Linear Peptide Glutathione (GSH) were restored significantly by Syzygium cumini seed treatment. Finally, our study revealed that supplementation of 1% Syzygium cumini seed with food attenuated inflammatory cell infiltration, collagen secretion, extracellular matrix deposition and iron overload in both hepatic and kidney. We assume that the protection might be achieved due to having strong antioxidant properties of Syzygium cumini.

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“…Deferoxamine is a chelating agent that binds free ferric iron (Fe 3+ ). It is used effectively in a variety of diseases associated with blood breakdown; it can prevent fibrosis by attenuating oxidative stress and the subsequent inflammatory cascade [ 182 ]. There are promising experimental data for treatment of intracerebral hemorrhage [ 183 ].…”

Section: Resultsmentioning

confidence: 99%

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review

Bigio

Curzio

2015

Fluids Barriers CNS

107

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Pharmacological interventions have been tested experimentally and clinically to prevent hydrocephalus and avoid the need for shunting beginning in the 1950s. Clinical trials of varied quality have not demonstrated lasting and convincing protective effects through manipulation of cerebrospinal fluid production, diuresis, blood clot fibrinolysis, or manipulation of fibrosis in the subarachnoid compartment, although there remains some promise in the latter areas. Acetazolamide bolus seems to be useful for predicting shunt response in adults with hydrocephalus. Neuroprotection in the situation of established hydrocephalus has been tested experimentally beginning more recently. Therapies designed to modify blood flow or pulsation, reduce inflammation, reduce oxidative damage, or protect neurons are so far of limited success; more experimental work is needed in these areas. As has been recommended for preclinical studies in stroke and brain trauma, stringent conditions should be met for preclinical studies in hydrocephalus.Electronic supplementary materialThe online version of this article (doi:10.1186/s12987-016-0025-2) contains supplementary material, which is available to authorized users.

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Antifibrotic mechanism of deferoxamine in concanavalin A induced-liver fibrosis: Impact on interferon therapy

Cited by 31 publications

References 57 publications

The potential antifibrotic impact of apocynin and alpha-lipoic acid in concanavalin A-induced liver fibrosis in rats: Role of NADPH oxidases 1 and 4

The potential antifibrotic impact of apocynin and alpha-lipoic acid in concanavalin A-induced liver fibrosis in rats: Role of NADPH oxidases 1 and 4

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

Nonsurgical therapy for hydrocephalus: a comprehensive and critical review

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