Antifibrotics and mortality in idiopathic pulmonary fibrosis: external validity and avoidance of immortal time bias
Hironao Hozumi,
Koichi Miyashita,
Eiji Nakatani
et al.
Abstract:Background and objective
Pooled analyses of previous randomized controlled trials reported that antifibrotics improved survival in patients with idiopathic pulmonary fibrosis (IPF), but the results were only based on short-term outcome data from selected patients who met strict criteria. Observational studies/meta-analyses also suggested that antifibrotics improve survival, but these studies failed to control for immortal time bias that considerably exaggerates drug effects. Therefore, whether … Show more
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