Antifilarial efficacy of green silver nanoparticles synthesized using Andrographis paniculata

Yadav, Smita; Sharma, Shweta; Ahmad, Faiyaz; Rathaur, Sushma

doi:10.1016/j.jddst.2020.101557

Cited by 14 publications

(17 citation statements)

References 34 publications

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“…N/A: Not available. Current study 34 23 12 40 Synthesis process Heating and mixing 3–7 h at 70 °C Reflux and vacuumed and heating at 90 °C Heating at 120 °C and mixing Room Temperature 1 h Room Temperature in dark – 24 h Plant material S. persica roots S. persica roots S. persica stem S. persica bark S. persica leaves Size of NPs 10–70 nm (average is 37.5 nm 10–20 nm 1–6 nm 50 nm 3–5 nm Shape of NPs Spherical and rod Spherical Spherical Spherical Spherical Characterization UV–Vis, FE-SEM, TEM, XRD, FTIR, DLS UV–Vis, SEM, HR-TEM, XRD, FTIR, EDX UV–Vis, SEM, HR-TEM, XRD, FTIR, EDX UV–Vis, SEM, HR-TEM, PXRD UV–Vis, FTIR TEM, SAED, XRD MIC and MBC (µg/ml) 0.19 and 0.39 for S. epidermidis (ATCC 12228) 0.78 and 0.39 for E. coli (ATCC 11229) N/A N/A 200 and ≥ 400 for S. aureus (ATCC 25923) 100 and 200 for E. coli (ATCC 25,922) N/A ZOI (mm) 20 for S. epidermidis and 15 for E. coli at 40 µg/ well 15 for S. aureus (ATCC 29213) and 13 for E. coli (ATCC 25922) at 100 µg/ well Pseudomonas aeruginosa (ATCC 27853) Micrococcus luteus (ATCC 10240) …”

Section: Discussionmentioning

confidence: 99%

“…They also exhibit effective antimicrobial efficacy against fungal pathogens 31 . Recently, applications of AgNPs in other biomedical fields have also been reported, for instance, anticoagulant activity 32 , thrombolytic effect 33 , anti-filarial 34 , anti-leishmania 35 , antilarval, anthelmintic, antioxidant activity and anticancer 36 . The applications of AgNPs in biomedical and pharmaceuticals will continue to rise, owing to their potential industrial applications related to global health and eco-benign production requiring cheaper raw materials and cost-effective procedures.…”

Section: Introductionmentioning

confidence: 99%

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Salvadora persica mediated synthesis of silver nanoparticles and their antimicrobial efficacy

Arshad

Sami

Sadaf

et al. 2021

Sci Rep

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Silver nanoparticles (AgNPs) exhibit strong antimicrobial properties against many pathogens. Traditionally employed chemical methods for AgNPs synthesis are toxic for the environment. Here, we report a quicker, simpler, and environmentally benign process to synthesize AgNPs by using an aqueous ‘root extract’ of Salvadora persica (Sp) plant as a reducing agent. The synthesized Salvadora persica nano particles (SpNPs) showed significantly higher antimicrobial efficacy compared to earlier reported studies. We characterized SpNPs using UV–Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), Field Emission Scanning Electron Microscopy (FE-SEM), Dynamic Light Scattering (DLS) and X-ray powder diffraction (P-XRD). UV–Vis spectrum showed the highest absorbance at 420 nm. FTIR analysis depicts presence of bond stretching including OH– (3300 cm−1), C=N– (2100 cm−1) and NH– (1630 cm−1) which are attributed in the involvement of phenolics, proteins or nitrogenous compounds in reduction and stabilization of AgNPs. TEM, FE-SEM and DLS analysis revealed the spherical and rod nature of SpNPs and an average size of particles as 37.5 nm. XRD analysis showed the presence of the cubic structure of Ag which confirmed the synthesis of silver nanoparticles. To demonstrate antimicrobial efficacy, we evaluated SpNPs antimicrobial activity against two bacterial pathogens (Escherichia coli (ATCC 11229) and Staphylococcus epidermidis (ATCC 12228)). SpNPs showed a significantly high inhibition for both pathogens and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were found to be 0.39 µg/mL and 0.78 µg/mL for E. coli while 0.19 µg/mL and 0.39 µg/mL for S. epidermidis respectively. Further, Syto 16 staining of bacterial cells provided a supplemental confirmation of the antimicrobial efficacy as the bacterial cells treated with SpNPs stop to fluoresce compared to the untreated bacterial cells. Our highly potent SpNPs will likely have a great potential for many antimicrobial applications including wound healing, water purification, air filtering and other biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salvadora persica mediated synthesis of silver nanoparticles and their antimicrobial efficacy

Arshad

Sami

Sadaf

et al. 2021

Sci Rep

View full text Add to dashboard Cite

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“…7,9 These chemical methods led to the release of chemicals that are harmful in nature into the atmosphere and make the synthesis process toxic because the chemical method's byproducts are harmful to the ecosystem. 9,187 Anticoagulant activity, 188 thrombolytic effect, 161 antifilarial, 189 antileishmanial, 190 antilarval, anthelmintic, antioxidant, and anticancer activity 191 are some of the recent uses of AgNPs in other biomedical fields. AgNPs have much potential for dealing with multidrug resistance (MDR) because microbes do not have any genotypic resistance to silver.…”

Section: Biologically Synthesizing Metallicmentioning

confidence: 99%

“…Anticoagulant activity, thrombolytic effect, antifilarial, antileishmanial, antilarval, anthelmintic, antioxidant, and anticancer activity are some of the recent uses of AgNPs in other biomedical fields. AgNPs have much potential for dealing with multidrug resistance (MDR) because microbes do not have any genotypic resistance to silver…”

Section: Biologically Synthesizing Metallic Nanoparticles From Plantsmentioning

confidence: 99%

Green Synthesis of Nanoparticles and Their Biomedical Applications: A Review

Shreyash

Bajpai

Khan

et al. 2021

ACS Appl. Nano Mater.

138

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In the arena of material sciences, one of the burning topics for research has been biogenically synthesizing nanoparticles (NPs) from plant derivatives and studying their applicability to be used as sustainable catalysts. The contemporary work happening on nanocatalysts focuses on the scope of application of green catalysts. For devising a technology that is ecofriendly as well as rapid, it seems a very viable option to biogenically synthesize NPs from plants. The potential that plants have in synthesizing these NPs has been mostly an unexplored venture, and the massive plant diversity is the reason for this is the lack of exploration. The NPs have antioxidant, antibacterial, and antimicrobial characteristics, which make them suitable candidates for application in different biomedical applications. This review begins with a discussion about the different natural products that are used for NP synthesis and goes on to discuss the factors that affect the synthesis. The authors have aimed to provide detailed information about green NPs and their applications in different biomedical areas. Existing literature on NP-based biomedical applications focuses more on synthetic NPs, and we hope that this review will help the readers to formulate a fresh perspective by concentrating their interests toward naturally synthesized NPs and their applications.

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“…An antifilarial study using AP-AGNPs on adult female filarial parasites reported a LC50 of 11.6 μg/mL and also showed a significant reduction in parasite levels. These novel green nanoparticles also induced oxidative stress with mitochondrial-mediated apoptosis for a superior antifilarial efficacy, compared to the free AP extract treated group, when tested in adult filarial parasitic worms [ 82 ].…”

Section: Advances In a Paniculata Nano-formulationsmentioning

confidence: 99%

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview

2022

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Andrographis paniculata is a well-known Asian medicinal plant with a major phytoconstituent of diterpene lactones, such as andrographolide, 14-deoxyandrographolide, and neoandrographolide. A World Health Organization (WHO) monograph on selected medicinal plants showed that A. paniculata extracts and its major diterpene lactones have promising anti-inflammatory, antidiabetic, antimalarial, anticancer, antifungal, antibacterial, antioxidant, and hypoglycemic activities. However, these active phytochemicals have poor water solubility and bioavailability when delivered in a conventional dosage form. These biological barriers can be mitigated if the extract or isolated compound are delivered as nanoparticles. This review discusses existing studies and marketed products of A. paniculata in solid, liquid, semi-solid, and gaseous dosage forms, either as an extract or isolated pure compounds, as well as their deficits in reaching maximum bioavailability. The pharmaceutics and pharmacological activity of A. paniculata as a nano-delivery system are also discussed.

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Antifilarial efficacy of green silver nanoparticles synthesized using Andrographis paniculata

Cited by 14 publications

References 34 publications

Salvadora persica mediated synthesis of silver nanoparticles and their antimicrobial efficacy

Salvadora persica mediated synthesis of silver nanoparticles and their antimicrobial efficacy

Green Synthesis of Nanoparticles and Their Biomedical Applications: A Review

Andrographis paniculata Dosage Forms and Advances in Nanoparticulate Delivery Systems: An Overview

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