Antifoam fouling and its reduction by surfactant precoat treatment of polysulphone ultrafilter

Yamagiwa, Kazuaki; Kobayashi, Hiroe; Onodera, Masayuki; Ohkawa, Akira

doi:10.1007/bf00155419

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…In another study, for a spin filter and cross flow filtration system, it was determined that filter fouling was due to the deposition of nucleic acids and dead cells . In other studies, membrane fouling due to antifoam has been studied …”

Section: Introductionmentioning

confidence: 99%

“…5,6 In other studies, membrane fouling due to antifoam has been studied. 7 Mathematical models have been developed to describe how transmembrane pressure (DP) should increase during constant flux dead-end filtration. This increase in pressure can be attributed most generally to an increase in total resistance (R tot ) due to the increased amounts of biological material deposited on the membrane per…”

Section: Introductionmentioning

confidence: 99%

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Understanding and modeling alternating tangential flow filtration for perfusion cell culture

Kelly

Scully

Zhang

et al. 2014

Biotechnology Progress

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Alternating tangential flow (ATF) filtration has been used with success in the Biopharmaceutical industry as a lower shear technology for cell retention with perfusion cultures. The ATF system is different than tangential flow filtration; however, in that reverse flow is used once per cycle as a means to minimize fouling. Few studies have been reported in the literature that evaluates ATF and how key system variables affect the rate at which ATF filters foul. In this study, an experimental setup was devised that allowed for determination of the time it took for fouling to occur for given mammalian (PER.C6) cell culture cell densities and viabilities as permeate flow rate and antifoam concentration was varied. The experimental results indicate, in accordance with D'Arcy's law, that the average resistance to permeate flow (across a cycle of operation) increases as biological material deposits on the membrane. Scanning electron microscope images of the post-run filtration surface indicated that both cells and antifoam micelles deposit on the membrane. A unique mathematical model, based on the assumption that fouling was due to pore blockage from the cells and micelles in combination, was devised that allowed for estimation of sticking factors for the cells and the micelles on the membrane. This model was then used to accurately predict the increase in transmembane pressure during constant flux operation for an ATF cartridge used for perfusion cell culture.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Understanding and modeling alternating tangential flow filtration for perfusion cell culture

Kelly

Scully

Zhang

et al. 2014

Biotechnology Progress

View full text Add to dashboard Cite

show abstract

“…, the component that can adsorb/accumulate on membrane surface or inside the membrane pores and causes fouling). The types of fouling are classified into five main types: colloidal fouling [ 5 ], scaling fouling [ 6 ], antifoam fouling [ 7 ], protein fouling [ 8 , 9 ], and membrane biofouling [ 10 , 11 ]. These types of fouling can be reduced using hydrodynamic [ 12 ], surface modification [ 13 ], and regular cleaning methods [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

PES Surface Modification Using Green Chemistry: New Generation of Antifouling Membranes

Nady¹

2016

Membranes

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A major limitation in using membrane-based separation processes is the loss of performance due to membrane fouling. This drawback can be addressed thanks to surface modification treatments. A new and promising surface modification using green chemistry has been recently investigated. This modification is carried out at room temperature and in aqueous medium using green catalyst (enzyme) and nontoxic modifier, which can be safely labelled “green surface modification”. This modification can be considered as a nucleus of new generation of antifouling membranes and surfaces. In the current research, ferulic acid modifier and laccase bio-catalyst were used to make poly(ethersulfone) (PES) membrane less vulnerable to protein adsorption. The blank and modified PES membranes are evaluated based on e.g., their flux and protein repellence. Both the blank and the modified PES membranes (or laminated PES on silicon dioxide surface) are characterized using many techniques e.g., SEM, EDX, XPS and SPM, etc. The pure water flux of the most modified membranes was reduced by 10% on average relative to the blank membrane, and around a 94% reduction in protein adsorption was determined. In the conclusions section, a comparison between three modifiers—ferulic acid, and two other previously used modifiers (4-hydroxybenzoic acid and gallic acid)—is presented.

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“…The properties of both the components and the membrane material are of importance, because they determine whether these components can attach/adsorb onto the membrane surface [ 1 , 2 ]. Membrane fouling can be caused by various components, such as colloidal particles [ 3 , 4 ], minerals [ 5 , 6 ], antifoam [ 7 , 8 ], proteins [ 9 , 10 ], and microorganisms [ 11 , 12 ]. Various remediation methods have been proposed to influence the interaction between these foulants (i.e., the components that can be adsorbed on or onto the membrane surface) and membranes, including adjustment of the system hydrodynamics [ 13 , 14 , 15 ], surface modification [ 16 , 17 ], and regular cleaning [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Protein-Repellence PES Membranes Using Bio-grafting of Ortho-aminophenol

et al. 2016

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Surface modification becomes an effective tool for improvement of both flux and selectivity of membrane by reducing the adsorption of the components of the fluid used onto its surface. A successful green modification of poly(ethersulfone) (PES) membranes using ortho-aminophenol (2-AP) modifier and laccase enzyme biocatalyst under very flexible conditions is presented in this paper. The modified PES membranes were evaluated using many techniques including total color change, pure water flux, and protein repellence that were related to the gravimetric grafting yield. In addition, static water contact angle on laminated PES layers were determined. Blank and modified commercial membranes (surface and cross-section) and laminated PES layers (surface) were imaged by scanning electron microscope (SEM) and scanning probe microscope (SPM) to illustrate the formed modifying poly(2-aminophenol) layer(s). This green modification resulted in an improvement of both membrane flux and protein repellence, up to 15.4% and 81.27%, respectively, relative to the blank membrane.

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Antifoam fouling and its reduction by surfactant precoat treatment of polysulphone ultrafilter

Cited by 6 publications

References 8 publications

Understanding and modeling alternating tangential flow filtration for perfusion cell culture

Understanding and modeling alternating tangential flow filtration for perfusion cell culture

PES Surface Modification Using Green Chemistry: New Generation of Antifouling Membranes

Protein-Repellence PES Membranes Using Bio-grafting of Ortho-aminophenol

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