Antifouling activity of natural products from Brazilian seaweeds

Gama, Bernardo A.P. da; Carvalho, Ana G V; Weidner, Kerstin; Soares, Angélica Ribeiro; Coutinho, Ricardo; Fleury, Beatriz G.; Teixeira, Valéria Laneuville; Pereira, Renato Crespo

doi:10.1515/bot.2008.027

Cited by 45 publications

(29 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These are mainly terpenes, acetogenins and polyphenols, including many halogenated compounds (Maschek & Baker, 2008). These secondary metabolites provide defense against herbivores (Pereira et al, 2004b;Lima et al, 2008), fouling organisms (Da Gama et al, 2008) and pathogens (Paul & Ritson-Williams, 2008); they also play a role in reproduction (Amsler & Fairhead, 2005), protection from UV radiation (Gomez et al, 1998) and as allelopathic agents (Beach et al, 2003). These compounds have shown some interesting pharmacological activities such as: antitumoral (Barbier et al, 2001), antiparasitic (Davyt et al, 2001), antibacterial (Vairappan, 2003), antiviral (Santos et al, 1999;Pereira et al, 2004a;Soares et al, 2007), antioxidant (Nahas et al, 2007), and antifungal activity (de Oliveira et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Soares¹,

Robaina²,

Mendes³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

Organic extracts of 36 species of marine algae (sixteen species of Rhodophyta, eight species of Ochrophyta and twelve species of Chlorophyta) from seven locations on the Brazilian coast were evaluated for their anti-HSV-1 and anti-HSV-2 activity resistant to Acyclovir (ACV). Activity tests in crude extracts, followed by the identification of the major compounds present, were performed for all species. The chemical profiles of all crude extracts were obtained by 1 H-NMR and 13 C-NMR spectroscopy. The percentage of extracts with antiviral activity was higher for HSV-1 (86.1%) than for HSV-2 (55.5%). The green algae Ulva fasciata and Codium decorticatum both showed the highest activity (99.9%) against HSV-1, with triacylglycerols and fatty acids as the major components. The red alga Laurencia dendroidea showed good activity against HSV-1 (97.5%) and the halogenated sesquiterpenes obtusol and (-)-elatol were identified as the major components in the extract. Against HSV-2, the green alga Penicillus capitatus (Chlorophyta) and Stypopodium zonale (Ochrophyta) were the most active (96.0 and 95.8%). Atomaric acid, a meroditerpene, was identified as the major secondary metabolite in the S. zonale extract. These results reinforce the role of seaweeds as important sources of compounds with the potential to enter into the pipeline for development of new drugs against herpes simplex.

show abstract

Section: Introductionmentioning

confidence: 99%

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Soares¹,

Robaina²,

Mendes³

et al. 2012

Rev. bras. farmacogn.

View full text Add to dashboard Cite

show abstract

“…Brazilian bioprospecting is only in the beginning, but this is the crucial moment to think about better strategies. There are good reasons to believe that many species of Brazilian seaweeds have unique characteristics that can be exploited to create the basis for new products and processes, such as novel antifouling agents (e.g., Da Gama et al, 2008) and pharmaceuticals (VeigaSantos et al, 2010). However, as verified worldwide, supply is a serious obstacle today and a limiting factor for the development of pharmaceuticals using marine secondary metabolites.…”

Section: Perspectivesmentioning

confidence: 99%

“…As one of the world´s largest countries, Brazil possesses about 8000 km of coastline and a rich macroalgae flora that is potentially a producer of bioactive secondary metabolites with pharmaceutical (Veiga-Santos et al, 2010) or antifouling (Da Gama et al, 2008) properties. In addition, this biodiversity offers unexplored opportunities and challenges for the discovery of new genes, enzymes, and processes, which might be very useful in the bioprospecting context.…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives

Pereira¹,

Costa-Lotufo²

2012

Rev. bras. farmacogn.

Self Cite

View full text Add to dashboard Cite

Seaweeds are potential sources of high biotechnological interest due to production of a great diversity of compounds exhibiting a broad spectrum of biological activities. On the other hand, there is an urgent need for management options for a sustainable approach to the use of marine organisms as a source of bioactive compounds. This review discusses the bioprospection for bioactive seaweed compounds as pharmaceuticals and antifouling agents, encompassing their potential and possible obstacles and alternatives. In spite of their potential, research on pharmaceuticals and antifouling agents from seaweeds includes mainly the search for molecules that exhibit these biological activities, but lacks of consideration of fundamental and limiting aspects such as the development of alternatives to sustainable supply. However, for the complete development of pharmaceuticals and antifouling compounds in Brazil, marine bioprospection should be more comprehensive, associating the search for molecules with an analysis of their supply. In this way, it is possible to promote sustainable development and conservation of biodiversity, as well as to assert the economic development of Brazil.

show abstract

“…Esses metabólitos podem, no futuro, ser utilizados como ingredientes ativos em tintas náuticas. 93 Outra abordagem que vem sendo testada recentemente é a aplicação de anti-incrustantes livres de biocidas. Esses revestimentos apresentam um mecanismo de ação totalmente diferente das tintas anti-incrustantes tradicionais.…”

Section: Perspectivasunclassified

Tintas anti-incrustantes de terceira geração: novos biocidas no ambiente aquático

2011

View full text Add to dashboard Cite

Recebido em 7/6/10; aceito em 11/1/11; publicado na web em 1/4/11 THIRD GENERATION ANTIFOULING PAINTS: NEW BIOCIDES IN THE AQUATIC ENVIRONMENT. Antifouling agents have been used on vessels and boats since ancient civilizations. Thus, a brief history on the three generations of antifouling paints was provided in the present review. Additionally, information about physic-chemical properties, environmental levels, toxicology and analytical methods was discussed for the 16 "new" booster biocides used as third-generation antifouling paints. The main problems, limitations and future trends related to this subject were also presented. Finally, actions were suggested in order to appraise the current status of the environmental impact caused by these compounds in South America.Keywords: antifouling; paint; booster biocides. INTRODUÇÃODentre os diversos grupos de contaminantes orgânicos potencialmente danosos a ecossistemas aquáticos, despontaram nos últimos anos os biocidas utilizados como princípio ativo de tintas antiincrustantes. Essas tintas são aplicadas como sistemas de proteção, com a finalidade de combater a formação e o estabelecimento de comunidades bioincrustantes (fouling) sobre superfícies expostas à água. Usualmente, tintas anti-incrustantes são aplicadas em embarcações comerciais e de passeio, plataformas petrolíferas, tubulações submarinas, comportas de represas, tanques destinados à aquicultura, dentre outras estruturas. 1Dentre as aplicações mencionadas para as referidas tintas, a utilização como revestimento protetor em embarcações tem sido apontada por muitos autores como a mais impactante para o ambiente, devido ao seu caráter altamente difundido em zonas costeiras.2 Segundo Kotrikla, 3 o emprego de sistemas anti-incrustantes em embarcações é justificado pelos seguintes motivos: o aumento da fricção entre o casco e a água, demanda uma maior potência dos motores e, consequentemente, gera um aumento no consumo de combustível; aumento da frequência de docagens, gerando um incremento de custos e de resíduos gerados; aumento das taxas de corrosão e, introdução não intencional de espécies exóticas em ambientes aquáticos.O primeiro registro de uso de sistemas anti-incrustantes data de 2 mil anos atrás, quando os cascos de madeira eram revestidos com chumbo e "untados" com misturas de óleo de baleia, enxofre e arsênio. Em 1625, uma receita letal combinando arsênio, cobre e goma em pó foi patenteada como agente anti-incrustante por Wilian Beale, na Inglaterra. A utilização de sistemas anti-incrustantes incorporados às tintas passou a ser comum, e cada vez mais frequente, na medida em que os cascos de madeira das embarcações foram substituídos por cascos metálicos, fato ocorrido em meados do século XVIII. A partir de então, a navegação comercial e o uso de embarcações de lazer se tornaram cada vez mais populares, aportando aos ambientes aquáticos quantidades cada vez maiores de biocidas utilizados em tintas anti-incrustantes. 1Em meados do século XX, os óxidos de cobre e de zinco foram os primeiros biocidas ut...

show abstract

Antifouling activity of natural products from Brazilian seaweeds

Cited by 45 publications

References 67 publications

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives

Tintas anti-incrustantes de terceira geração: novos biocidas no ambiente aquático

Contact Info

Product

Resources

About