Antifouling polyethersulfone hemodialysis membranes incorporated with poly (citric acid) polymerized multi-walled carbon nanotubes

Abidin, Muhammad Nidzhom Zainol; Goh, Pei Sean; Ismail, Ahmad Fauzi; Othman, Mohd Hafiz Dzarfan; Hasbullah, Hasrinah; Said, Noresah; Kadir, Siti Hamimah Sheikh Abdul; Kamal, Fatmawati; Abdullah, Mohd Sohaimi; Ng, Be Cheer

doi:10.1016/j.msec.2016.06.039

Cited by 66 publications

(44 citation statements)

References 39 publications

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“…This was due to the enhanced surface hydrophilicity of the membranes as the result of the good dispersion of hydrophilic IONPs. The lowest BSA adsorption achieved was 3.3 μg/cm 2 by the M1:25 membrane; this was lower compared to those (5.0 and 4.5 μg/cm 2 ) found in previous studies by Abidin et al . The improved dispersion of the IONPs ensured a uniform hydrophilic surface of the membrane and, hence, minimized protein adsorption.…”

Section: Resultscontrasting

confidence: 65%

“…The improved membrane porosity, supported by the increased hydrophilicity, also increased the water passage across the membrane . PWP enhancement was a good sign for efficient water separation, as the faster water flow left the hydrophobic protein molecules behind . Beyond an IONP/CA weight ratio of 1:20, the thicker membrane active skin layer with smaller pores on the surface of the membrane imposed more resistance toward the movement of water molecules and hence reduced the PWP.…”

Section: Resultsmentioning

confidence: 98%

“…It is the key to minimizing the protein adsorption, particularly on the membrane surface; this usually occurs because of the hydrophobic interactions between the membrane surface and the protein molecules . The protein adsorption may block the membrane pores and thus cause fouling of the membranes . Figure displays the contact angle measurements collected.…”

Section: Resultsmentioning

confidence: 99%

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Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Said

Hasbullah

Abidin

et al. 2019

J of Applied Polymer Sci

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Protein existence in wastewater is an important issue in wastewater management because proteins are generally present as contaminants and foulants. Hence, in this study, we focused on designing a polysulfone (PSf) hollow-fiber membrane embedded with hydrophilic iron oxide nanoparticles (IONPs) for protein purification by means of ultrafiltration. Before membrane fabrication, the dispersion stability of the IONPs was enhanced by the addition of a stabilizer, namely, citric acid (CA). Next, PSf-IONP-CA nanocomposite hollow-fiber membranes were prepared via a dry-wet spinning process and then characterized in terms of their hydrophilicity and morphology. Ultrafiltration and adsorption experiments were then conducted with bovine serum albumin as a model protein. The results that an IONP/CA weight ratio of 1:20 contributed to the most stable IONP dispersion. It was also revealed that the membrane incorporated with IONP-CA at a weight ratio of 1:20 exhibited the highest pure water permeability (58.6 L m −2 h −1 bar −1 ) and protein rejection (98.5%) while maintaining a low protein adsorption (3.3 μg/cm 2 ). The addition of well-dispersed IONPs enhanced the separation features of the PSf hollow-fiber membrane for protein purification.

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Section: Resultscontrasting

confidence: 65%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Said

Hasbullah

Abidin

et al. 2019

J of Applied Polymer Sci

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“…PEG brushes enhanced membranes to an extent, but instability and cleavage along with low hemocompatibility was still an issue. Beside PEG, several hydrophilic structures, such as poly(vinyl pyrrolidone) (PVP) [34] and poly(vinyl alcohol) (PVA) [44], sulfonated structures [45], and nanomaterials [46,47] were used for modification of dialysis membranes. Currently, researchers are targeting third generation, including zwitterionic polymeric surfaces which are believed to be better than second generation due to better performance of the PEG immobilizations due to higher hemocompatibility and stability [48][49][50][51].…”

Section: Hemocompatibility Enhancementsmentioning

confidence: 99%

Challenges and Advances in Hemodialysis Membranes

Mollahosseini¹,

Abdelrasoul²,

Shoker³

2020

Advances in Membrane Technologies

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Hemodialysis (HD) is a filtration vital process through which the bloods' toxins and contaminations are removed. However, several immune system activations occur during dialysis, which can result in morbidity and mortality. The efficiency of the currently available blood purification process is hindered, on one hand, by the deficient toxins and middle molecule removal, and on the other hand, with the loss of valuable blood components (such as plasma and its constituents). This chapter offers an overview of the challenges and advances in HD membranes. It includes an introduction of the end stage renal disease, concepts of dialysis, its historical background, and the path through which the configurations and materials evolved. The interactions between membrane polymeric materials with human blood is also discussed. The aspect of material modification is one of the critical areas in HD technology as it targets to solve the most immediate and prevalent HD issue of membrane bioincompatibility. High flux dialysis (HFD) and hemofiltration (HF) are introduced and discussed. This class of membranes was introduced to solve middle molecule (such as β2-microglobulin) related challenges. This chapter highlights the question of why the issue of incompatible materials still exists along with current membrane modifications.

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“…Despite their wide acceptance for many applications, PSf‐based membranes have some disadvantages which originate from their hydrophobic nature . The drawbacks include a decline in fluid transport properties and separation performance . Hydrophobic proteins, e.g.…”

Section: Introductionmentioning

confidence: 99%

Enhanced hydrophilic polysulfone hollow fiber membranes with addition of iron oxide nanoparticles

et al. 2017

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Membranes are at the heart of hemodialysis treatment functions to remove excess metabolic waste such as urea. However, membranes made up of pure polymers and hydrophilic polymers such as polyvinylpyrrolidone suffer problems of low flux and bio-incompatibility. Hence, this study aimed to improve polysulfone (PSf) membrane surface properties by the addition of iron oxide nanoparticles (IONPs). The membrane surface properties and separation performance of neat PSf membrane and membrane filled with IONPs at a loading of 0.2 wt% were investigated and compared. The membranes were characterized in terms of morphology, pure water permeability (PWP) and protein rejection using bovine serum albumin (BSA). A decrease in contact angle value from 66.62 ∘ to 46.23 ∘ for the PSf/IONPs membrane indicated an increase in surface hydrophilicity that caused positive effects on the PWP and BSA rejection of the membrane. The PWP increased by 40.74% to 57.04 L m −2 h −1 bar −1 when IONPs were incorporated due to the improved interaction with water molecules. Furthermore, the PSf/IONPs membrane rejected 96.43% of BSA as compared to only 91.14% by the neat PSf membrane. Hence, the incorporation of IONPs enhanced the PSf hollow fiber membrane hydrophilicity and consequently improved the separation performance of the membrane for hemodialysis application.

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Antifouling polyethersulfone hemodialysis membranes incorporated with poly (citric acid) polymerized multi-walled carbon nanotubes

Cited by 66 publications

References 39 publications

Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Facile modification of polysulfone hollow‐fiber membranes via the incorporation of well‐dispersed iron oxide nanoparticles for protein purification

Challenges and Advances in Hemodialysis Membranes

Enhanced hydrophilic polysulfone hollow fiber membranes with addition of iron oxide nanoparticles

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