Antifouling zwitterionic hydrogel coating improves hemocompatibility of activated carbon hemoadsorbent

Cai, Nana; Li, Qingsi; Zhang, Jiamin; Xu, Tong; Zhao, Weiqiang; Yang, Jing; Zhang, Lei

doi:10.1016/j.jcis.2017.04.024

Cited by 76 publications

(57 citation statements)

References 47 publications

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“…The positive charges on the backbone of polysaccharide hydrogels are thought to be effective in disrupting the lipid membrane of microbes, resulting in antimicrobial activity. Another category of anti-biofouling hydrogel coatings is zwitterionic hydrogels, which are neutral but have an equal number of positive and negative charges along the polymer network [ 49 , 51 ]. The most frequently studied zwitterionic materials are prepared by adhering poly(sulfo-betaine) and poly(carboxybetaine) to methacrylate or acrylamide backbones.…”

Section: Functions and Applications Of Hydrogel Coatingsmentioning

confidence: 99%

Functional hydrogel coatings

Liu

Suo

et al. 2020

National Science Review

284

158

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Hydrogels—natural or synthetic polymer networks that swell in water—can be made mechanically, chemically, and electrically compatible with living tissues. There has been intense research and development of hydrogels for medical applications since the invention of the hydrogel contact lenses in 1960. More recently, functional hydrogel coatings with controlled thickness and tough adhesion have been achieved on various substrates. Hydrogel-coated substrates combine the advantages of hydrogels, such as lubricity, biocompatibility, and anti-biofouling properties, with the advantages of the substrates, such as stiffness, toughness, and strength. In this review, we focus on three aspects of functional hydrogel coatings: (1) applications and functions enabled by hydrogel coatings, (2) methods of coating various substrates with different functional hydrogels with tough adhesion, and (3) tests to evaluate the adhesion between functional hydrogel coatings and substrates. Conclusions and outlook are given at the end of this review.

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Section: Functions and Applications Of Hydrogel Coatingsmentioning

confidence: 99%

Functional hydrogel coatings

Liu

Suo

et al. 2020

National Science Review

284

158

View full text Add to dashboard Cite

show abstract

“…This further demonstrated the antiadhesive properties of the hydrogel after photocrosslinking. Results of the hemolysis assay also showed that all the HAD samples had no obvious hemolytic effect on blood cells, as the hemolysis ratios were <1%, indicating no obvious hemolysis [ 22 ] (Figure S13d,e, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

An Injectable Asymmetric‐Adhesive Hydrogel as a GATA6⁺ Cavity Macrophage Trap to Prevent the Formation of Postoperative Adhesions after Minimally Invasive Surgery

Guo

Ling

et al. 2021

Adv Funct Materials

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Antiadhesive hydrogels have been developed for preventing the formation of postoperative adhesions. However, it is challenging to design an injectable hydrogel with superior tissue retention properties that can be easily administered during minimally invasive surgical procedures to prevent the development of postsurgical adhesions. In this study, an injectable asymmetric‐adhesive hydrogel is fabricated using photocurable catechol‐grafted hyaluronic acid (HAD) for use during minimally invasive procedures to prevent the development of postoperative adhesions. The hydrogel exhibits superior tissue retention properties and favorably inhibits postoperative adhesion formation. This is the first time that an injectable hydrogel is designed via photocrosslinking to control asymmetric‐adhesive capability. The results show that laparoscopically delivered HAD precursor acts as a wet adhesive on the injured cecum, while its outward‐facing side is nonadherent after photocrosslinking. Intriguingly, the HAD acts as a physical barrier and polyanion trap to neutralize scavenger receptors, thereby inhibiting collagen deposition and uncontrolled recruitment of GATA6+ cavity macrophages. Furthermore, the HAD significantly downregulates the expression of fibrosis‐related and proinflammatory cytokines and promotes macrophage polarization. These results demonstrate that injection of the hydrogel can be readily integrated into laparoscopic surgery. Moreover, the HAD may be suitable for preventing adhesion formation after minimally invasive surgical procedures.

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“…Zwitterionic-based materials, which are famous for their excellent hydrophilicity and anti-adhesion property, were used as surface coating materials on hemoperfusion materials. [65][66][67][68][69][70][71] researches of Zhang et al 72 and Qi et al 73 respectively, the modified activated carbon demonstrated that the adsorbents were highly hemocompatible with fresh blood, while the adsorbing ability of pCBMA coating was much better than pCB coating. Besides, the hydrophilic polymer brushes were also used as surface coating materials due to their resistance to protein and cell adsorption.…”

Section: Materials Advances Accepted Manuscriptmentioning

confidence: 99%

A critical review of hemoperfusion adsorbents: materials, functionalization and matrix structure selection

et al. 2022

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Antifouling zwitterionic hydrogel coating improves hemocompatibility of activated carbon hemoadsorbent

Cited by 76 publications

References 47 publications

Functional hydrogel coatings

Functional hydrogel coatings

An Injectable Asymmetric‐Adhesive Hydrogel as a GATA6⁺ Cavity Macrophage Trap to Prevent the Formation of Postoperative Adhesions after Minimally Invasive Surgery

A critical review of hemoperfusion adsorbents: materials, functionalization and matrix structure selection

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Antifouling zwitterionic hydrogel coating improves hemocompatibility of activated carbon hemoadsorbent

Cited by 76 publications

References 47 publications

Functional hydrogel coatings

Functional hydrogel coatings

An Injectable Asymmetric‐Adhesive Hydrogel as a GATA6+ Cavity Macrophage Trap to Prevent the Formation of Postoperative Adhesions after Minimally Invasive Surgery

A critical review of hemoperfusion adsorbents: materials, functionalization and matrix structure selection

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An Injectable Asymmetric‐Adhesive Hydrogel as a GATA6⁺ Cavity Macrophage Trap to Prevent the Formation of Postoperative Adhesions after Minimally Invasive Surgery