Antifungal action and targeted mechanism of Bio fabricated zinc oxide (ZnO) nanoparticles against Ascochytafabae

Sharma, Indu; Sharma, Manu Vineet; Haque, M. Akiful; Simal-Gandara, Jesus

doi:10.1016/j.heliyon.2023.e19179

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…The current study is a continuation of our research program aimed at developing antibacterial polymer-metal composites [49][50][51][52][53][54] and is focused on the PLA-Zn composites made from a matrix with hemostatic properties [35][36][37][38][39][40] (but without an inherent antibacterial effect [55]) and with an antipathogenic (antibacterial [56][57][58][59][60][61][62][63][64][65]; antiviral [66][67][68][69][70][71][72][73][74][75][76][77]; and antifungal [78][79][80][81][82][83][84][85][86][87]), hemostatic [88][89][90]…”

Section: Introductionmentioning

confidence: 99%

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Mrozińska,

Ponczek,

Kaczmarek

et al. 2024

Coatings

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This article presents the biochemical properties of poly(lactide)-zinc (PLA-Zn) composites obtained by DC magnetron sputtering of zinc onto melt-blown nonwoven fabrics. The biochemical properties were determined by the evaluation of the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The antimicrobial activity of the PLA-Zn samples was additionally tested against representative Gram-positive and Gram-negative bacteria strains. A structural study of the PLA-Zn has been carried out using specific surface area and total pore volume (BET) analysis, as well as atomic absorption spectrometry with flame excitation (FAAS). PLA-Zn composites exhibited an antibacterial effect against the analyzed strains and produced inhibition zones against E. coli and S. aureus. Biochemical investigations revealed that the untreated PLA fibers caused the acceleration of the clotting of human blood plasma in the intrinsic pathway. However, the PLA-Zn composites demonstrated significantly different properties in this regard, the aPTT was prolonged while the PT was not altered.

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