Antifungal activities of azole agents against the Malassezia species

Malassezia Species Associated With Dermatitis in Dogs and Their Antifungal Susceptibility

“…More resistant species reported are M. pachydermatis (Nakamura et al, 2000), M. furfur (Duarte et al, 2006), M. globosa and M. restricta (Rincon et al, 2006). Whereas M. sympodialis has been frequently found more susceptible to the tested antifungals (Miranda et al, 2007). The susceptibility of the yeast isolates to antifungal agents via a disk diffusion methodology was assessed following disk diffusion guidelines and interpretive zone sizes based on the CLSI standard.…”

Antifungal Susceptibility of Malassezia Species Isolated From Pityriasis Versicolor Cases

“…In agreement with other reports, this study also found higher in vitro antifungal activity against all the tested clinical isolates of Malassezia spp, with itraconazole. [8,14,16] In this study fluconazole MICs were significantly higher than those observed for other azole drugs and ranged from ≤ 0.125 µg/mL -16µg/mL for all the isolates in PV cases. This is similar to or lower than those documented in various other studies.…”

“…These results are similar to or higher than those documented in various other studies. [15,18,19] MIC ranges against itraconazole shown in several studies are as follows: < 0.03-16µg/mL, [16] 0.007 -0.05μg/mL, [19] 3µg/mL -0.125µg/mL [6] and ≤ 0.03 -0.06 µg/mL. [4] Gupta AK et al [17] found the MIC data obtained for itraconazole were similar to MICs for itraconazole and ketoconazole with an MIC of 0.8µg/ml for both.…”

“…This is similar to or lower than those documented in various other studies. [15,16,18] The various MIC ranges against fluconazole shown in various studies are ≤ 0.125 -> 64 µg/mL, [16] 0.06 µg/mL -1.0 µg/mL, [18] ≤ 0.5 µg/mL -32 µg/mL, [6] 0.25µg/mL -4 µg/mL, [8] 0.25µg/mL -256 µg/mlL [14] and ≤ 0.125 -> 64µg/mL. Remya et al…”

Epidemiologic Study of Malassezia Yeasts in Seborrheic Dermatitis Patients by the Analysis of 26S rDNA PCR-RFLP

“…There are also other hypotheses, including a relationship with the lipophilic Malassezia yeasts as resident flora of the skin, and abnormalities of neurotransmitters and epidermal hyperplasia. Furthermore, there are several studies stating that clinical symptoms showed improvement along with decreased amounts of yeasts when treating SD with azole antimycotics 2,3 . In an animal experiment, when Malassezia yeasts are applied to the skin, a lesion similar to SD appeared, indicating a need for further study into the relationship between SD and Malassezia yeasts 4 .…”