Antifungal Activity and Chemical Composition of the Essential Oils ofLippia alba(Miller) N.E Brown Grown in Different Regions of Colombia

Essential oils biological activity of the Lippia alba (Verbenaceae) shrub

“…Nematicidal activity of chemotypes I and III was reported on Meloidogyne incognita at concentrations from 0.1-2.5 ml/L, which had mean mortality percentages from 22 to 100 %, in dependent dosage; and diminished eclosion rate from 47 to 9 % (Moreira, Santos, & Innecco, 2009). Antimicrobial and antifungal activity has been reported on periodontal-pathogenic microorganisms (Juiz et al, 2015;Bersan et al, 2014), cariogenic organisms (Bersan et al, 2014), enterobacteria (Pino, Ortega, Rosado, Rodríguez, & Baluja, 1996;Machado, Nogueira, Pereira, Sousa, & Batista, 2014), dermatophytes (Costa et al, 2014;Tangarife-Castaño et al, 2012), phytopathogens (Mena-Rodríguez, Ortega-Cuadros, Merini, Melo- Ríos, & Tofiño-Rivera, 2018;Anaruma et al, 2010), sulfate reductase (Souza et al, 2017a), important pathogens in aquiculture (Souza et al, 2017b;Majolo, Rocha, Chagas, Chaves, & Bizzo, 2017;Sutili et al, 2015), Candida albicans (Mesa-Arango et al, 2010;Santos et al, 2016a;Mesa-Arango et al, 2009), aspergillosis (Mesa-Arango et al, 2010;Glamočlija, Soković, Tešević, Linde, & Colauto, 2011;Mesa-Arango, et al, 2009), Cryptococcosis (Santos et al, 2016a); gastrointestinal, cutaneous, and nosocomial infections (Pino et al, 1996;Machado et al, 2014;Porfírio et al, 2017); under the MIC interval between 4.0-9 370 µg/ml and MBC 6.5-2 500 µg/ml for bacteria (Table 2), and MIC 31.25-2 000 and MBC/ MFC 500-1 250 µg/ml for fungus (Table 3). 2008), and is approved for over-the-counter sale as antiseptic for external use and adjuvant in the treatment of anxiety of nervous origin in humans (INVIMA, 2018).…”

“…In biomedical sciences, research has provided effective tools to solve problems related with amoebic infections (Santos et al, 2016b), herpetic infections (Agudelo-Gómez et al, 2010), tropical diseases e.g. like dengue (Ocazionez et al, 2010), leishmaniasis (Escobar et al, 2010;Neira et al, 2018), trypanosomiasis (Escobar et al, 2010;Baldissera et al 2017;Moreno et al, 2018), and yellow fever (Meneses et al, 2009), control of vectors, like Aedes aegypti (Vera et al, 2014;Castillo et al, 2017;Ríos et al, 2017;Aldana & Cruz, 2017), mycosis (Mesa-Arango et al, 2010;Santos et al, 2016a;Glamočlija et al, 2011), in-hospital diseases (Santos et al, 2016a;Pino et al, 1996;Machado et al, 2014), and diseases related with the oral cavity (Juiz et al, 2015;Bersan et al, 2014).…”

HS-SPME as an efficient tool for discriminating chemotypes of Lippia alba (Mill.) N. E. Brown

“…[14][15][16] According to Hennebelle et al, 13 besides the existence of different morphotypes of L. alba, the plant also has seven chemotypes which are characterized by different major constituents in their essential oils. 13 Later on, Mesa-Arango et al 10 suggested the existence of at least twelve chemotypes of this species. These authors reported the citral and carvone chemotypes for the plant collected in Colombia, besides the promising antifungal activity of its essential oil.…”

“…[1][2][3][4] Additionally, L. alba displays sedative, anxiolytic, antiulcer, antifungal, antimicrobial, antioxidant, antispasmodic, anti-nociceptive and antiinflammatory activities. [5][6][7][8][9][10] The ethnopharmacological importance of L. alba was recognized in Europe by its introduction in the French Pharmacopeia and by its approval by the French Drug Agency (AFSSaPS). It is worth mentioning that L. alba and Senna alata (L.) Roxb.…”

“…These authors reported the citral and carvone chemotypes for the plant collected in Colombia, besides the promising antifungal activity of its essential oil. 10 The investigation of the essential oil composition of L. alba collected in Uruguay revealed the monoterpenes canfora and 1,8-cineole as major constituents, while the essential oil of the same species collected in Cuba has carvone and b-guaiene as major compounds. 17,18 Studies on the chemical composition of the essential oil of L. alba collected in different regions of Brazil also revealed the existence of different chemotypes of the plant.…”