Antifungal activity and Shore A hardness of a tissue conditioner incorporated with terpinen-4-ol and cinnamaldehyde

Maior, Laura de Fátima Souto; Maciel, Panmella Pereira; Ferreira, Víctor Yuri Nicolau; Dantas, Cíntia de Lima Gouveia; Lima, Jefferson Muniz de; Castellano, Lúcio Roberto Cançado; Batista, André Ulisses Dantas; Bonan, Paulo Rogério Ferreti

doi:10.1007/s00784-019-02925-w

Cited by 18 publications

(8 citation statements)

References 40 publications

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“…Zareshahrabadi et al showed that the viscoelastic modulus of an experimental antimicrobial modified tissue conditioner was reduced indicating increase in hardness value [ 21 ]. In another study by Manior et al, it was concluded that terpinen-4-ol and cinnamaldehyde resulted in increased shore A hardness of experimental and control tissue conditioner over 7 days period [ 22 ]. Similarly, Urban et.…”

Section: Discussionmentioning

confidence: 99%

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

et al. 2022

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This study aims to compare the hardness, sorption and solubility of commercially available tissue conditioner [TC] modified with chitosan [CS] and synthesized chitosan oligosaccharide [COS] in antifungal concentration. COS was synthesized by acid hydrolysis and characterized by FTIR and XRD. Experimental materials were formulated by incorporating each per gram of TC powder with effective antifungal concentration of chitosan 1.02 mg (Group 1: TC-CS) and 0.51 mg COS (Group 2: TC-COS). A commercially available TC was used as control (Group 0: CTC). Shore A hardness test was performed according to ASTM D 2240-05 (2010) standards on samples stored in dry environment, distilled water (DW) and artificial saliva (AS) at 37 °C (n = 5 per group). Percent weight changes (n = 5 per group) after storage in DW and AS was used to record sorption and solubility. One-way Anova with post hoc Tukey’s test was applied. FTIR and XRD confirmed low molecular weight and amorphous nature of COS. Experimental groups had higher Shore A hardness values; however, these changes were not significant. Greatest variations in durometer values (p ≤ 0.05) were observed during the first 24 h. Experimental groups had higher (p ≤ 0.05) percentage sorption and solubility. Samples stored in DW had significantly higher (p = 0.019) sorption, whereas material had higher (p = 0.005) solubility in AS. Mean solubility values in both immersion mediums was highest for Group 2, followed by group 1 and group 0. In addition, significant (p ≤ 0.05) increase in solubility upon aging was noted for each material. Experimental tissue conditioner had higher hardness, sorption and solubility. However, these changes are not substantial to interfere with their tissue healing property. Therefore, these materials may be considered and explored further as potential antimicrobial drug delivery agent for denture stomatitis patients.

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Section: Discussionmentioning

confidence: 99%

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

et al. 2022

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“…On the other hand, alcohols were the second major class, owing to the enrichment of oil with erpinene-4-ol (12.06%), spathulenol (5.8%), trans-ascaridol glycol (4.66%), and α -terpineol (4.43%). Terpinen-4-ol (4) exerted antibacterial and antifungal activities [ 42 ], while spathulenol (27, 33) demonstrated anti-hyperalgesic and anti-nociceptive effects in chronic pain [ 43 ]. trans-Ascaridol glycol (8) was previously reported in oils of Chenopodium, revealing antimicrobial and anti-inflammatory activities [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation

et al. 2022

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The GC-MS analysis of tea tree oil (TTO) revealed 38 volatile components with sesquiterpene hydrocarbons (43.56%) and alcohols (41.03%) as major detected classes. TTO efficacy is masked by its hydrophobicity; nanoencapsulation can address this drawback. The results showed that TTO-loaded solid lipid nanoparticles (SLN1), composed of glyceryl monostearate (2% w/w) and Poloxamer188 (5% w/w), was spherical in shape with a core-shell microstructure. TTO-SLN1 showed a high entrapment efficiency (96.26 ± 2.3%), small particle size (235.0 ± 20.4 nm), low polydispersity index (0.31 ± 0.01), and high negative Zeta potential (−32 mV). Moreover, it exhibited a faster active agent release (almost complete within 4 h) compared to other formulated TTO-SLNs as well as the plain oil. TTO-SLN1 was then incorporated into cellulose nanofibers gel, isolated from sugarcane bagasse, to form the ‘TTO-loaded nanolipogel’ which had a shear-thinning behavior. Second-degree thermal injuries were induced in Wistar rats, then the burned skin areas were treated daily for 7 days with the TTO-loaded nanolipogel compared to the unmedicated nanolipogel, the TTO-loaded conventional gel, and the normal saline (control). The measurement of burn contraction proved that TTO-loaded nanolipogel exhibited a significantly accelerated skin healing, this was confirmed by histopathological examination as well as quantitative assessment of inflammatory infiltrate. This study highlighted the success of the proposed nanotechnology approach in improving the efficacy of TTO used for the repair of skin damage induced by burns.

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“…48 Yakın tarihli bir başka çalışmada ise doku şartlandırıcıya terpinen-4-ol ve sinnamaldehit eklenmiş ve materyalin antifungal etkisi Candida aktivitesi ölçülerek araştırılmıştır. 49 Buna ilaveten Shore A sertliği değerlendirilmiştir. Çalışma sonucunda sinnamaldehitin, %10-40 konsantrasyonlarda Candida biyofilm oluşumunu inhibe ettiği ve terpinen-4-ol modifikasyonundan daha etkili olduğu bulunmuştur.…”

Section: çEşitli Tıbbi Bitkilerin Doku şArtlandırıcılara İlavesi Son...unclassified

“…Çalışma sonucunda sinnamaldehitin, %10-40 konsantrasyonlarda Candida biyofilm oluşumunu inhibe ettiği ve terpinen-4-ol modifikasyonundan daha etkili olduğu bulunmuştur. 49…”

Section: çEşitli Tıbbi Bitkilerin Doku şArtlandırıcılara İlavesi Son...unclassified

Tıbbi Bitkilerin Doku Şartlandırıcılara İlave Edilmesiyle Antibakteriyel ve Antifungal Etkinlik Sağlanabilir Mi?

TAS

EGİLMEZ

2023

ADO Klinik Bilimler Dergisi

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The aim of this study is to review the literature on the addition of medicinal plants to tissue conditioners in order to benefit from their anti-inflammatory, antibacterial and antioxidant properties and to provide evidence-based information for a successful treatment. In this study, a literature search was conducted in Medline database via PubMed in order to evaluate the antimicrobial and antifungal properties of plants in dentistry and to examine the results obtained when added to tissue conditioners. As a result of the evaluated articles, it has been determined that the addition of plants to tissue conditioners can be an alternative supportive treatment option in dentistry. However, after all the evaluations, further studies are needed in terms of the long-term success and clinical use of these applications.

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Antifungal activity and Shore A hardness of a tissue conditioner incorporated with terpinen-4-ol and cinnamaldehyde

Cited by 18 publications

References 40 publications

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation

Tıbbi Bitkilerin Doku Şartlandırıcılara İlave Edilmesiyle Antibakteriyel ve Antifungal Etkinlik Sağlanabilir Mi?

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