2022
DOI: 10.2217/fmb-2021-0095
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Antifungal Activity and Toxicity of an Octyl Gallate-Loaded Nanostructured Lipid System on Cells and Nonmammalian Animals

Abstract: Aim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering and showed adequate size (132.1 nm) and homogeneity (polydispersity index = 0.200). OG was active against Paraccoccidioides spp., and NLS-OG did not affect antifungal activity. NLS-OG demonstrated reduced toxicity to lung cells and zebrafish embryos compared with OG, whereas NLS was t… Show more

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