Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora

Kumar, Rajesh; Chaturvedi, A. K.; Shukla, Praveen Kumar; Lakshmi, Vijai

doi:10.1016/j.bmcl.2006.12.052

Cited by 51 publications

(23 citation statements)

References 13 publications

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“…Wound healing was significantly better when compared to gold standard for minor wound treatment like flavine. This effect could be due to the large number of therapeutic properties of sea cucumber, which includes antioxidant (Althunibat et al 2009), antimicrobial (Kumar et al 2007), anti-inflammatory (Bordbr et al 2011), antiviral and other wound healing properties (Aydin et al 2011;Fredalina et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Optimum Dose of Sea Cucumber (Stichopus Chloronotus) Extract for Wound Healing

Mazliadiyana¹,

As²,

Mohamed³

2017

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ABSTRAK ABSTRACTIn Malaysia, sea cucumber is also known as Gamat. Among the Malays, Gamat is frequently used as a traditional or folk medicine to relieve pain, to treat wounds and burns. It is also used as a tonic to provide extra energy. Stichopus chloronotus is one of the species of sea cucumber which is found in Malaysia. An experimental study was carried out to determine the optimum dose of aqueous extract of Stichopus et al. 2011). Stichopus chloronotus (Black Knobby or green fish) is one of the common species that can be found around indo-Pacific Ocean such as Taiwan, Singapore, Thailand and Malaysia. It is the second most common species found in Malaysia (Choo 2008). It has been reported that Stichopus chloronotus has composition of fatty acid which is important and play a key role in wound healing process (Fredalina et al. 1999). Therefore, we conducted a scientific evaluation of optimum dose chloronotus on the healing of wounds in rat model. A series of concentrations 0.1%, 0.5% and 1% aqueous extract emulsifying ointment mixed with Stichopus chloronotus was applied once a day for 10 days on the excision wound model. Changes in the wound area were measured using a caliper and photographs were taken on day 1, 3, 6, 8 and 10 after the wound creation. The wound reduction rate and macroscopic observation were evaluated to determine the optimum dose concentration. Results demonstrated that percentage of wound reduction and macroscopic observation of 0.5% aqueous extract Stichopus chloronotus emulsifying ointment mixed group was significantly higher than the other groups from day 6 following wound creation. In conclusion, 0.5% aqueous extract of Stichopus chloronotus emulsifying ointment mixture demonstrated the best dose for wound healing in a rat model.

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Section: Discussionmentioning

confidence: 99%

Optimum Dose of Sea Cucumber (Stichopus Chloronotus) Extract for Wound Healing

Mazliadiyana¹,

As²,

Mohamed³

2017

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“…The antifungal activity has previously been described in some species of echinoderms (Batrakov et al 1980;Kumar et al 2007;Mohammadizadeh et al 2013;Mokhlesi et al 2011). The antifungal activity of the extracts of the respiratory tree was more than the extracts of the body wall and intestine of the sea cucumber, Holothuria scabra, against Candida albicans and Aspergillus niger (Mohammadizadeh et al 2013).…”

Section: Antifungal Effects Of the Extractsmentioning

confidence: 97%

Bioactivity of aqueous and organic extracts of sea cucumber Holothuria leucospilota (Brandt 1835) on pathogenic Candida and Streptococci

et al. 2018

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Holothurians (sea cucumbers) exist almost in all benthic marine environments and they are an important species for the commercial fisheries. In this study, the antimicrobial activity of different tissues of the sea cucumber, as a marine invertebrate, was investigated. The bacteria, Streptococcus mutans and Streptococcus sobrinus, the fungi, Candida parapsilosis, Candida albicans and Candida glabrata, were chosen for antimicrobial test, because they are opportunistic pathogens. The body wall, respiratory tree, and gastrointestinal tract of the sea cucumbers were utilized to make the extracts. Phosphate-buffered saline (PBS), ethanol (Et), and acetonitrile (ACN) were used as solvents for aqueous and organic extractions. The results showed that there were antimicrobial active compounds against infective streptococci and candid fungi. Streptococcus mutans was generally more tolerant than Streptococcus sobrinus to the sea cucumber extracts. The extracts of the respiratory tree with ACN and PBS, as solvents, showed the highest effect against Candida albicans, Candida parapsilosis and Candida glabrata. The extracts of gastrointestinal tract and the body wall with Et and PBS, respectively, had not any antifungal activity. The antimicrobial activities had been found in different extracts of the sea cucumber tissues, which could be related to the protein and non-protein compounds.

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“…The methanolic fraction showed the highest potential in growth inhibition tests against the two strains indicating the presence of bioactive compounds with antifungal properties. Numerous chemical and pharmacological studies carried out on several species of sea cucumbers indicate that these invertebrate contain triterpene glycoside (saponins) with bioactive properties as antifungal, anti-inflammatory, cytotoxic and others [5] [23]. Also, saponins are highly revealed in the methanolic fraction since they are a polar solvent [11].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

The Biotechnological and Seafood Potential of <i>Stichopus regalis</i>

Santos¹,

Dias²,

Pintéus³

et al. 2015

ABB

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Sea cucumbers are highly used not only for the production of the bêche-de-mer, but also recent studies have been showing the high potential of these marine invertebrates on the pharmaceutical industry, as they are rich in bioactive compounds with important functions. Stichopus regalis extracts (1 mg•mL −1 ) were used in antioxidant, antimicrobial and antitumor assays. The lipid profile was also evaluated. No significant antioxidant activity was detected in both methanolic and dichloromethane extracts. The methanolic fraction showed the highest antimicrobial potential against Candida albicans with an IC 50 of 475.4 μg•mL −1 . In the antitumor assays, the dichloromethane fraction showed a high potential for both cell lines, as revealed by the MTT method. The total fat content was 3.63% ± 0.11% and the fatty acid profile revealed the highest amount in C16:0 (9.43% ± 0.77%), C18:0 (12.43% ± 0.83%), C18:1 ω7 (5.63% ± 0.33%), EPA (12.49% ± 0.15%), DHA (7.35% ± 0.02%), ARA (19.29% ± 0.14%) and a ω3/ω6 ratio of 1.078. These findings led us to suggest the potential use of S. regalis as a new source of bioactive compounds with pharmacological potential and its nutritional benefits for human health.

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Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora

Cited by 51 publications

References 13 publications

Optimum Dose of Sea Cucumber (Stichopus Chloronotus) Extract for Wound Healing

Optimum Dose of Sea Cucumber (Stichopus Chloronotus) Extract for Wound Healing

Bioactivity of aqueous and organic extracts of sea cucumber Holothuria leucospilota (Brandt 1835) on pathogenic Candida and Streptococci

The Biotechnological and Seafood Potential of <i>Stichopus regalis</i>

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Antifungal activity in triterpene glycosides from the sea cucumber Actinopyga lecanora

Cited by 51 publications

References 13 publications

Optimum Dose of Sea Cucumber (Stichopus Chloronotus) Extract for Wound Healing

Optimum Dose of Sea Cucumber (Stichopus Chloronotus) Extract for Wound Healing

Bioactivity of aqueous and organic extracts of sea cucumber Holothuria leucospilota (Brandt 1835) on pathogenic Candida and Streptococci

The Biotechnological and Seafood Potential of &lt;i&gt;Stichopus regalis&lt;/i&gt;

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The Biotechnological and Seafood Potential of <i>Stichopus regalis</i>