Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

Elias, Rebecca; Benhamou, Raphael I.; Jaber, Qais Z.; Dorot, Orly; Zada, Sivan Louzoun; Oved, Keren; Pichinuk, Edward; Fridman, Micha

doi:10.1016/j.ejmech.2019.07.003

Cited by 53 publications

(31 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Coumarin-based antifungal azoles had been further investigated by Elias and co-workers, who, in 2019, developed a series of 11 coumarins conjugated with 1,2,4-triazole and imidazole motifs [96]. The analysis of the biological effects of these novel chemical entities highlighted that imidazole-based derivatives ( Figure 24) were more efficient against several Candida strains compared to 1,2,4-triazole derivatives.…”

Section: Antifungal Activitymentioning

confidence: 99%

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

276

156

View full text Add to dashboard Cite

Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and it can be found in a considerable number of plants as well as in some fungi and bacteria. In the last years, these natural compounds have been gaining an increasing attention from the scientific community for their wide range of biological activities, mainly due to their ability to interact with diverse enzymes and receptors in living organisms. In addition, coumarin nucleus has proved to be easily synthetized and decorated, giving the possibility of designing new coumarin-based compounds and investigating their potential in the treatment of various diseases. The versatility of coumarin scaffold finds applications not only in medicinal chemistry but also in the agrochemical field as well as in the cosmetic and fragrances industry. This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches.

show abstract

Section: Antifungal Activitymentioning

confidence: 99%

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

276

156

View full text Add to dashboard Cite

show abstract

“…Coumarin-substituted triazole antifungals 20 were screened against a panel of Candida pathogens by Elias et al. [ 40 ] and live-cell imaging revealed that fluorescent 7-diethylaminocoumarin-based triazoles localized to the fungal cell endoplasmic reticulum ( Fig. 4 ).…”

Section: Biological Activities Of 124-triazole Derivativesmentioning

confidence: 99%

An insight on medicinal attributes of 1,2,4-triazoles

Aggarwal

Sumran²

2020

European Journal of Medicinal Chemistry

212

View full text Add to dashboard Cite

The present review aims to summarize the pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant, antituberculosis, antiviral, antiparasitic, analgesic and anti-inflammatory agents, etc. along with structure-activity relationship. The comprehensive compilation of work carried out in the last decade on 1,2,4-triazole nucleus will provide inevitable scope for researchers for the advancement of novel potential drug candidates having better efficacy and selectivity.

show abstract

“…The World Health Organization has launched a global action plan that calls on all countries to take measures against drugresistant microbes, and the discovery of effective and safer antimicrobials with new or multiple mechanisms of action has been an urgent need to combat resistant strains. Therefore, developing an antifungal drug against new, safe and resistant strains has been an important field of study for researchers [1][2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New Series Benzothiazole-Dithiocarbamate Derivatives As Potential Antifungal Agents

Osmaniye¹,

Sağlık²

2022

Deu Muhendislik Fakultesi Fen Ve Muhendislik

View full text Add to dashboard Cite

İnvaziv mantar enfeksiyonları (IFI'lar) insan için büyük bir tehdit olmuştur ve olmaya devam edecektir. Günümüzde birçok tıbbi araştırmanın amacı yeni daha güvenli ve daha etkili antifungal ajanlar bulmaktır. Benzotiyazol bileşikleri, çok çeşitli biyolojik aktiviteleri nedeniyle farmasötik kimyada önemli bir farmakofor yapıdır. Ayrıca, ditiyokarbamat bileşikleri kimyasal yapıları nedeniyle birçok aktivite için önemli hale gelmiştir. Bu çalışmada, yeni sentezlenen benzotiyazolditiyokarbamat bileşiklerinin antifungal etkinliklerinin belirlenmesi amaçlanmıştır. Elde edilen bileşiklerin yapıları, 1 H-NMR, 13 C-NMR ve kütle spektroskopisi kullanılarak aydınlatılmıştır.

show abstract

Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

Cited by 53 publications

References 41 publications

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

An insight on medicinal attributes of 1,2,4-triazoles

Synthesis and Characterization of New Series Benzothiazole-Dithiocarbamate Derivatives As Potential Antifungal Agents

Contact Info

Product

Resources

About