Antifungal activity of anthraquinone derivatives from Rheum emodi

Agarwal, S. K.; Singh, Sudhir S.; Verma, S. C.; Kumar, Sushil

doi:10.1016/s0378-8741(00)00195-1

Cited by 328 publications

(164 citation statements)

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“…Rhein and chrysophanol are known to be present in the roots [2], in addition to two other quinone pigments [18]. These anthraquinone derivatives are well known to exhibit a variety of biological activities [19], such as antimicrobial [2], antifungal [20], antitumor [21], antioxidant [22], cytotoxic [23], and hypoglycemic [24] activities. The flavonoid kaempferol has been reported to have anticancer properties [25,26].…”

Section: Published In Final Edited Form Asmentioning

confidence: 99%

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Fernand

Dinh

Washington

et al. 2008

Talanta

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A simple high performance liquid chromatography (HPLC) method was developed and validated for the determination of six phenolic compounds, five anthraquinones (rhein, aloe-emodin, emodin, chrysophanol and physcion) and a flavonoid (kaempferol), in root extracts from Cassia alata L. Solid-phase extraction, using C 18 cartridges, was used to remove interfering substances from the root extracts. The extracts were analyzed on a C 18 column using an isocratic mobile phase which consisted of acetonitrile, methanol, and 10 mM aqueous ammonium acetate (25: 55: 20, v/v). Identification of the analytes was performed by use of standards and on-line mass spectrometric detection using atmospheric pressure chemical ionization. The concentration of the phenolic compounds in the root extracts was determined using HPLC with ultraviolet detection at 260 nm. The limits of detection obtained for the anlytes were in the range of 0.23 -4.61 ppm. The overall R.S.D. precision values (intra and inter-day) for the retention times and peak-areas were lower than 0.16% and 2.10%, respectively. In addition, the recovery of the developed method for the analysis of these phenolic compounds was determined, and ranged from 81.2 ± 4.3% to 106 ± 2%.

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Section: Published In Final Edited Form Asmentioning

confidence: 99%

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Fernand

Dinh

Washington

et al. 2008

Talanta

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“…Anthraquinones have recently attracted increasing attention due to their various biological activities and a wide range of applications in the pharmaceutical industry [1][2][3][4]. Additionally, some anthraquinones have been proved to posses anti-cancer and antifungal properties [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, some anthraquinones have been proved to posses anti-cancer and antifungal properties [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…2 10.0 ν C13C15 (13), ν C10C11 (13), ν O5C9 (9), ν C12C13 (6), ν C8C19 (6), 3 β 3/R6 (5) 76 1615.0 82.5 6.3 ρ N3H23 (19), ν C6C19 (8), ν C8C19 (7), ν C16C18 (7), ν C10C11 (7), ν C7C18 (7), ν C13C15 (7), 1 β 2/R6 (5) 77 1627.4 34.0 15.0 ν C14C15 (14), ν C11C12 (11), ν O5C9 (8), 3 β 2/R6 (7), ν C12C13 (7), ν C6C7 (5) 78 1631.2 279.7 4.8 ν C6C7 (16), ν C8C19 (6), 1 β 3/R6 (6), ν C14C15 (6), ν O4C17 (6) (8), ω N3H23 (6) 7 162.7 0.4 0.3 4 bfl RR (14), τ N3C18 (10), 2 bfl RR (10), 1 (13), 4 bfl RR (10) 11 221.4 5.2 0.4 τ S1C20 (21), δ 2/C20H31H32 (12), 2 bfl RR (8), β C18N3C2 (7), 4 bfl RR (7) (14), ν C11C17 (10), δ 2/C20H31H32 (7), ν C9C16 (6) 17 425.5 10.2 0.3 3 τ 3/R6 (40), ρ C9O5 (12), 4 bfl RR (10), 3 (15), ν S1C20 (8), ρ C18N3 (6) 27 652.2 1.9 0.9 ν S1C20 (58), 3 (8), ω C15H29 …”

mentioning

confidence: 99%

“…1.6 ρ C20H31H32 (25), β C20S1H33 (14), 1 β 3/R6 (8), 1 β trig/R6 (5) 35 785.9 5.5 0.3 3 τ 1/R6 (18), 2 τ 1/R6 (13), ω C7H25 (12), ω C9O5 (10), ω C19H30 (10), ω C17O4 (9), ω C6H24 (9) 36 796.0 0.1 0.7 1 β trig/R6 (13), ρ C20H31H32 (12), β C20S1H33 (12), 3 β 2/R6 (10), 1 β 3/R6 (9), 3 β trig/R6 (7) 37 808.4 0.5 0.1 ω C9O5 (25), ω C13H27 (13) (12), ν C8C19 (10), ν C11C17 (7), ρ C6H24 (6), ρ C14H28 (6) 58 1221.4 39.6 0.5 τ C20H31H32 (51), τ C2H22H21 (10) 59 1256. (7) 61 1293.8 528.9 10.6 (5) 62 1317.6 120.0 1.…”

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Relationship between structure and entropy contributions in an anthraquinone mercapto derivative

2010

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The structural and thermodynamic properties of an anthraquinone derivative were studied by means of quantum-chemical calculations. As a result of the conformational analysis fourteen lowenergetic conformers were found by using ab initio and DFT methods. In order to discuss similarities and differences in entropy of the conformers, the rotational and vibrational contributions to entropy were correlated with changes in the conformer structure. The moment of inertia perpendicular to the molecular plane gives significant input to the ΔSrot, whereas the largest contributions to the ΔSvib have the vibrations associated with the τS1C20 coordinate.Response to Reviewers: Dear Prof. Andrzej Sokalski Editor in Chief of Journal of Molecular Modeling, I would like to thank the Referees for a careful reading of our manuscript and giving us the valuable comments that with no doubts will improve this paper (Mns.# JMMO1081). Please find below my answers to the Referees' suggestions and comments.Reviewer #1:Major Revisions 1. Some anthraquinones are proved to have anti-cancer and antifungal properties, as stated by the authors in the introduction. There, the anthraquinones are not in gas phase, but solved in the liquid phase or are interacting with the target in the liquid phase. In contrast, the calculations of the authors are performed in the gas phase. Thus, the authors should discuss, if their results have significance in drug research and for interaction between ligand and target. The molecular structure defined in the gas phase is a commonly accepted starting point in studies concerning biological activities of molecules. Indeed, we agree with the referee that the future research dealing strictly with biological activity of anthraquinones would require introduction of the solvent and simulation of a biological environment in computational models that is, by the way, a nontrivial problem. However, our studies on antraquinones brought us to finding of the entropic effect in the structures of the MEAA conformers and we decided to analyze this effect in detail. Therefore, our work, although mentioning biological functions of MEAA conformers, was in fact aimed to study the correlation of the rotational and vibrational contributions to entropy with changes in the conformer structure and to do this, the simplest possible model (the gas phase) occurred to us as the most preferable. In order to clarify our point of view we suggest adding two more sentences to Introduction (after : The highest emphasis was made on detailed analysis of the entropy effect in order to understand the relation between the structure and entropy contributions (translational, electronic, rotational and vibrational). The computations were done in the gas phase to simplify the computations. Nevertheless, it is hoped that this study can be a starting point in the future research concerning modeling of the biological activity of the MEAA in more complicated systems, mimicking the biological environment.2. How was the analysis of the potential energy p...

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Botany, Geographical Distribution, Phytochemistry and Phytopharmaceutical Potential ofRheum emodiWall. ex Meisn.: An Overview

Shahnawaz¹,

Dar²,

Jeelani³

et al. 2021

Phytopharmaceuticals

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Antifungal activity of anthraquinone derivatives from Rheum emodi

Cited by 328 publications

References 6 publications

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Relationship between structure and entropy contributions in an anthraquinone mercapto derivative

Botany, Geographical Distribution, Phytochemistry and Phytopharmaceutical Potential ofRheum emodiWall. ex Meisn.: An Overview

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