Antifungal activity of <i>Glycyrrhiza glabra</i> extracts and its active constituent glabridin

Fatima, Atiya; Gupta, Vivek Kumar; Luqman, Suaib; Negi, Arvind S.; Kumar, Jonnala Kotesh; Shanker, Karuna; Saikia, Dharmendra; Srivastava, Sangeeta; Darokar, Mahendra P.; Khanuja, S. P. S.

doi:10.1002/ptr.2726

Cited by 89 publications

(58 citation statements)

References 11 publications

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“…Fatima et al, (2009) For the Candida strains in which considerable antifungal effect were observed, the effect on biofilm formation was carried out, namely to C. glabrata strains (ATCC2001, D1 and 513100) and C. tropicalis (ATCC750 and T2.2). Despite C. tropicalis strains, namely AG1 and T2.2, as well as ATCC750, 12 and 519468 have evidenced a similar response to the extract, a representative strain of each group was selected.…”

Section: Resultsmentioning

confidence: 99%

In vitro anti-Candida activity of Glycyrrhiza glabra L.

Martins

Ferreira

Henriques

et al. 2016

Industrial Crops and Products

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2 AbstractThe severity and frequency of opportunistic fungal infections still growing, concomitantly to the increasing rates of antimicrobial drug's resistance. Natural matrices have been used over years due to its multitude of health benefits, including antifungal potential. Thus, the present work aims to evaluate the anti-Candida potential of the phenolic extract and individual phenolic compounds of Glycyrrhiza glabra L.(licorice), by disc diffusion assay, followed by determination of the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) for both planktonic cells and biofilms.Licorice extract evidenced inhibitory potential against the nineteen tested Candida strains, but no pronounced effect was observed by testing the most abundant individual phenolic compounds. Candida tropicalis strains were the most sensible, followed by Candida glabrata, Candida parapsilosis and, then, Candida albicans. Lower MIC and MFC values were achieved to C. glabrata and C. tropicalis, which confirms its susceptibility to licorice extract; however, for C. tropicalis strains a higher variability was observed. Anti-biofilm potential was also achieved, being most evident in some C. glabrata and C. tropicalis strains. In general, a twice concentration of the MIC was necessary for planktonic cells to obtain a similar potential to that one observed for biofilms. Thus, an upcoming approach for new antifungal agents, more effective and safer than the current ones, is stablished; notwithstanding, further studies are necessary in order to understand its mechanism of action, as also to assess kinetic parameters.

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Section: Resultsmentioning

confidence: 99%

In vitro anti-Candida activity of Glycyrrhiza glabra L.

Martins

Ferreira

Henriques

et al. 2016

Industrial Crops and Products

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“…The antifungal effects of G. glabra extract, and its active constituent glabridin, on antibiotic-resistant Candida albicans species were studied in different studies (9). The current research showed antifungal effects of G. glabra extracts on C. albicans species.…”

Section: Discussionmentioning

confidence: 71%

Efficacy of Some Medicinal Plants Extracts for Potential Antifungal Activity

Abkhoo

Jahani

2016

Int J Infect

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Background: Peganum harmala, Glycyrrhiza glabra, Mentha spicata and Rosmarinus officinalis are often used in traditional medicine. Objectives: The current study aimed to screen the antifungal activity of ethanolic extracts of P. harmala, G. glabra, M. spicata and R. officinalis leaves collected from Sistan region, Iran against Fusarium oxysporum. Methods: Minimal inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of herbal extracts were determined. Results: Of the total herbal extracts, four showed fungistatic activities and two showed fungicidal activities. MIC values, ranged 6.25 -50 ppm and MFC values, ranged 12.5 -100 ppm. The ethanolic extract of G. glabra had the lowest MIC (6.25 ppm); while the ethanolic extract of R. officinalis had the highest MIC (50 ppm). Minimum bactericidal concentration (MBC) of the alcoholic extract of G. glabra showed the highest efficiency against F. oxysporum at the low value of 12.5 ppm. Conclusions:The results of the study showed the antifungal activity of medicinal plants against F. oxysporum. Especially, the bioactive compounds of G. glabra were effective to inhibit the growth of F. oxysporum.

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“…Therefore, Glycyrrhiza glabra might be useful in the treatment of diarrhea caused by rotavirus infection [16]. Antifungal activity of liquorice extract is due to its active compound identified as glabridin (3-(2',4'-dihydroxyphenyl)-8-dimethylpyrano [8,7-e]chroman) which also demonstrates the resistance modifying activity against drug resistant mutants Candida albicans and Aspergellus niger [17]. The in-vitro and in-vivo anti-malarial activity of 18-β-glycirrhetic acid an active constituent of Glycyrrhiza glabra was also found to be effective [18].…”

Section: Therapeutic Potentials and Traditional Usesmentioning

confidence: 99%

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Thakur¹,

Raj²

2017

JAPLR

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The Glycyrrhiza genus contains more than 30 species and widely distributed all over the world [7]. Glycyrrhiza genus plants are wide spread in Mediterranean, Southern and Central Russia and Asia, being minor to Iran. Many species are now grown throughout Europe, Syria, Asia, UK, USA, Italy, France, Germany, AbstractGlycyrrhiza glabra Linn. (Family: Fabaceae) is a traditional medicinal plant used in various ancient medicine systems and documented across the globe for its ethanopharmacological value to cure varieties of ailments. Glycyrrhizin is the major active constituent obtained from liquorice roots, one of the most widely used in herbal preparations for the treatment and management of chronic diseases. The present mini-review is focused mainly on major secondary metabolites, ethnopharmacology and potential medicinal uses of Glycyrrhiza glabra. The sources for the literature search were PubMed, ScienceDirect, SciFinder and Google Scholar. Reported pharmacological activities, characterized secondary metabolites and traditional uses of Glycyrrhiza glabra warrants its potential therapeutic uses. However, further scientific validations along with evidencebased studies are still required in support to its traditional uses, to serve as "lead" for development of novel agents and a better drug candidate in future. Keywords:

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Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin

Cited by 89 publications

References 11 publications

In vitro anti-Candida activity of Glycyrrhiza glabra L.

In vitro anti-Candida activity of Glycyrrhiza glabra L.

Efficacy of Some Medicinal Plants Extracts for Potential Antifungal Activity

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

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