Antifungal activity of<i>Pterocaulon alopecuroides</i>(Asteraceae) against chromoblastomycosis agents

Daboit, Tatiane Caroline; Stopiglia, Cheila Denise Ottonelli; Poser, Gilsane Lino von; Scroferneker, Maria Lúcia

doi:10.1111/j.1439-0507.2009.01704.x

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…An ethnoveterinary survey indicated that plants from the genus Pterocaulon (Asteraceae) are used in Brazilian traditional medicine to treat skin diseases caused by both bacteria and fungi [2]. In recent years, various pharmacological studies conducted on the extracts of these plants have supported their ethnomedical use and the biological properties are attributed to coumarins, the most abundant compounds found in these species [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Coumarins in Aqueous Extract of Pterocaulon balansae (Asteraceae) and Characterization of a New Compound

et al. 2015

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Abstract:Plants from the genus Pterocaulon are popularly used as antifungal and wound-healing agents. Such activities have been related to coumarins, which are abundant in those plants. Coumarins are soluble in organic solvents, such as hexane and dichloromethane, and some of them are also soluble in hot water. Considering that infusion and decoctions of these plants are used in traditional medicine, the aim of this study was to identify and quantify the coumarins in the aqueous extract of Pterocaulon balansae. The aqueous extract was obtained by dynamic maceration and the compounds were characterized by UPLC-UV-MS analysis. A new coumarin and 5-methoxy-6,7-methylenedioxycoumarin, used for validation of the analytical HPLC method were obtained by partition of the aqueous extract with n-hexane. The HPLC method validated was linear, specific, and precise. Seven coumarins were characterized in the aqueous extract in a range of 0.584-54 mg/g of dry plant material. The main compound, 5,6-dimethoxy-7-(3′-methyl-2′,3′-dihydroxybutyloxy)coumarin, is described for the first time in P. balansae together with a new compound, 5,6-dimethoxy-7-(2′,3′-epoxy-3′-methylbutyloxy)coumarin.

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Section: Introductionmentioning

confidence: 99%

Quantification of Coumarins in Aqueous Extract of Pterocaulon balansae (Asteraceae) and Characterization of a New Compound

et al. 2015

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“…Invasive pulmonary aspergillosis remains a frequently fatal complication of bone marrow transplantation and of cancer chemotherapy in patients with haematologic neoplasms 3,4 . In many cases, treatment of these invasive fungal infection diseases is hampered by the toxicity of a limited number of available antifungal agents and also resistance to these agents by fungal pathogens 5 . This situation has led to an ongoing search for fungicidal agents with different modes of action and fewer side effects and which can be administered parenterally.…”

Section: Introductionmentioning

confidence: 99%

Substituted 2‐aminothiophenes: antifungal activities and effect on Microsporum gypseum protein profile

Fogue

Lunga

Fondjo

et al. 2011

Mycoses

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The increasing recognition and importance of fungal infections, the difficulties encountered in their treatment and the increase in resistance to antifungal agents have stimulated the search for therapeutic alternatives. The objective of this study was to evaluate the antifungal activities of three substituted 2-aminothiophenes (1, 2 and 3) against some fungal species. The synthesis of substituted 2-aminothiophenes was carried out through the most versatile synthetic method developed by Gewald et al. The antifungal activity was performed against yeast, dermatophytes and Aspergillus species using the broth microdilution method. The effect of these aminothiophenes was examined on the protein content and profile. Compound 2 was the most active (MIC varying from 2.00 to 128 μg ml(-1) ). All the three substituted 2-aminothiophenes had a relatively important dose-dependent effect on Microsporum gypseum protein profile and content. These compounds affected the structure and dye fixation of macroconidia of this fungus. The overall results indicate that the tested substituted 2-aminothiophenes can be used as precursors for new antifungal drugs development.

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“…Plants of the genus Pterocaulon have shown activities against different fungi, bacteria, and protozoa (Alarcón et al 2008;Ródio et al 2008;Daboit 2010). This study has demonstrated that P. polystachyum essential oil can reduce the A. polyphaga trophozoites viability.…”

Section: Discussionmentioning

confidence: 69%

“…A study of Stein and colleagues (2005) and Daboit et al (2010) showed that Pterocaulum alopecuroides, Pterocaulum balansae, and Pterocaulum polystachyum extracts were active against a range of pathogenic fungi. The hexane extract of the latter plant showed amoebicidal activity against a pathogenic strain of Acanthamoeba (Ródio et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Amoebicidal activity and chemical composition of Pterocaulon polystachyum (Asteraceae) essential oil

Sauter¹,

Santos

Apel

et al. 2011

Parasitol Res

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Acanthamoeba species are free-living amoebae that constitute an etiological agent of Acanthamoeba keratitis, an illness that may cause severe ocular inflammation and blindness and has a very difficult treatment. These molecules that are found in plants may be an alternative for the development of new drugs. Plants of the genus Pterocaulon (Asteraceae) are used in folk medicine as an antiseptic and antifungal agent. In this work, we analyzed Pterocaulon polystachyum essential oil and assessed its amoebicidal activity against Acanthamoeba polyphaga. The leaves of the fresh plant submitted to hydrodistillation yielded 0.15% (w/v) of essential oil that was analyzed by gas chromatography-mass spectrometry being E-sesquilavandulyl acetate as the major component, representing 43.8% of the oil. For the assessment of the amoebicidal activity, concentrations of 20, 10, 5, 2.5, and 1.25 mg/mL of essential oil were tested, being lethal to 100% of the A. polyphaga trophozoites at the concentrations of 10 and 20 mg/mL in 24 and 48 h. The cytotoxic effect of essential oil was also tested in mammalian cells using MTT assay. Amoebicidal activity results are in accordance with previous work in which the lipophilic compounds from this plant were active against Acanthamoeba castellanii. However, further studies with the major component of the essential oil will be carried out.

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Antifungal activity ofPterocaulon alopecuroides(Asteraceae) against chromoblastomycosis agents

Cited by 13 publications

References 31 publications

Quantification of Coumarins in Aqueous Extract of Pterocaulon balansae (Asteraceae) and Characterization of a New Compound

Quantification of Coumarins in Aqueous Extract of Pterocaulon balansae (Asteraceae) and Characterization of a New Compound

Substituted 2‐aminothiophenes: antifungal activities and effect on Microsporum gypseum protein profile

Amoebicidal activity and chemical composition of Pterocaulon polystachyum (Asteraceae) essential oil

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