Antifungal activity of lactic acid bacteria of Lactobacillus genus

Klewicka, Elżbieta; Lipińska, Lidia

doi:10.15193/zntj/2016/104/098

Cited by 5 publications

(7 citation statements)

References 58 publications

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“…Of particular application interest are lactobacilli, which convert carbohydrates into lactic and acetic acids (primary metabolites), as well as a range of secondary metabolites, such as carbon dioxide, ethanol, hydrogen peroxide, fatty acids, acetoin, diacetyl, cyclic dipeptides, bacteriocins, and bacteriocin-like inhibitory substances [ 3 ]. Since these metabolites exhibit only weak antifungal properties, many research teams are seeking Lactobacillus strains with a higher natural ability to inhibit fungal and yeast growth [ 4 , 9 , 14 , 15 , 26 ]. Ryu et al [ 26 ] reported that Lactobacillus plantarum HD1 synthesizes 5-oxododecanoic acid (MW 214), 3-hydroxydecanoic acid (MW 188), and 3-hydroxy-5-dodecenoic acid (MW 214), which are considered antifungal.…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Lactobacillus pentosus ŁOCK 0979 in the Presence of Polyols and Galactosyl-Polyols

Lipińska

Klewicki

Sójka

et al. 2017

Probiotics & Antimicro. Prot.

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The antifungal activity of Lactobacillus pentosus ŁOCK 0979 depends both on the culture medium and on the fungal species. In the control medium, the strain exhibited limited antagonistic activity against indicator food-borne molds and yeasts. However, the supplementation of the bacterial culture medium with polyols (erythritol, lactitol, maltitol, mannitol, sorbitol, xylitol) or their galactosyl derivatives (gal-erythritol, gal-sorbitol, gal-xylitol) enhanced the antifungal properties of Lactobacillus pentosus ŁOCK 0979. Its metabolites were identified and quantified by enzymatic methods, HPLC, UHPLC-MS coupled with QuEChERS, and GC-MS. The presence of polyols and gal-polyols significantly affected the acid metabolite profile of the bacterial culture supernatant. In addition, lactitol and mannitol were used by bacteria as alternative carbon sources. A number of compounds with potential antifungal properties were identified, such as phenyllactic acid, hydroxyphenyllactic acid, and benzoic acid. Lactobacillus bacteria cultivated with mannitol synthesized hydroxy-fatty acids, including 2-hydroxy-4-methylpentanoic acid, a well-described antifungal agent. Scanning electron microscopy (SEM) and light microscopy confirmed a strong antifungal effect of L. pentosus ŁOCK 0979.

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Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Lactobacillus pentosus ŁOCK 0979 in the Presence of Polyols and Galactosyl-Polyols

Lipińska

Klewicki

Sójka

et al. 2017

Probiotics & Antimicro. Prot.

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“…8) The antifungal activity of Lactobacillus was enhanced in the presence of xylitol and sorbitol. 9,10) Xylitol and sorbitol also enhanced the fungicidal effect of benzethonium chloride in vitro C. albicans biofilm. 11) A decrease in the number of yeast in human stool was observed after a single 30 g oral dose of xylitol.…”

Section: Introductionmentioning

confidence: 92%

“…In the presence of xylitol and sorbitol, antifungal activities of Lactobacillus were enhanced and these effects were suggested to be due to the synthesis of specific metabolites and/or peptides with antifungal properties. 9,10) Similarly, the growth and invasion of C. albicans in the gastrointestinal tract were influenced by the types of carbohydrate supplementation. Xylitol intake inhibited the growth of C. albicans in the gastrointestinal tract compared to sucrose intake.…”

Section: Candidacidal Activity Of Xylitol and Sorbitol At A High Concmentioning

confidence: 99%

Candidacidal Activity of Xylitol and Sorbitol

Kim¹,

Kim²,

Chang³

et al. 2016

Journal of Oral Medicine and Pain

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Purpose: It has been reported that xylitol and sorbitol affect antifungal activities by enhancing antimicrobial activities of other substances. The purpose of this study was to investigate the direct candidacidal activities of xylitol and sorbitol at a wide range of concentration.Methods: Xylitol and sorbitol solubilized with simulated salivary buffer at a range of 0.8 µM to 1.05 M were used. Candida albicans strains, ATCC strains 10231, 11006, and 18804 were used for the candidacidal assay. The candidacidal activities of xylitol and sorbitol were determined by comparing the numbers of colony forming units between in the presence and absence of xylitol or sorbitol and calculating the percent loss of cell viability.Results: There were some differences in the candidacidal activities according to the types of sugar alcohols and C. albicans strains. The candidacidal activity of more than 10% was observed when a final concentration of 32.9 mM in xylitol or sorbitol was maintained and that of about 20% was observed when a final concentration of 131 mM was maintained. Even at a high concentration of 1.05 M, the candidacidal activity of xylitol or sorbitol was about 20%. Conclusions:Xylitol and sorbitol at the concentrations used in commercial oral health care products had some levels of candidacidal activities.

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“…Kefir is defined as a beverage with antibacterial, antifungal [9][10][11], and antioxidant properties [12][13][14]. There are also data indicating the anticancer properties of kefir [13,15,16]. Literature data showed that kefir grain microflora is a complex of microorganisms characterized by the ability to release and produce compounds with bioactive properties from milk and its fraction (whey) [6,9,16].…”

Section: Introductionmentioning

confidence: 99%

“…Factors affecting the growth of microorganisms include temperature, the concentration of hydrogen ions, redox potential, water activity, and hydrostatic pressure [15].…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Activity of Selected Lactic Acid Bacteria for Bioconversion of Milk and Whey from Goat Milk to Release Biomolecules with Antibacterial Activity

Biadała

Szablewski

Cegielska‐Radziejewska

et al. 2023

Molecules

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The aim of the study was to assess the antibacterial features of functional macromolecules released during the fermentation of goat milk and whey from goat milk by selected lactic acid bacteria strains that are components of kefir grain microflora. Two milk sources were used: goat milk and whey from goat milk. The lactic acid bacteria (LAB) and indicator microorganisms used were Lactobacillus plantarum PCM 1386, Lactobacillus fermentum PCM 491, Lactobacillus rhamnosus PCM 2677, Lactobacillus acidophilus PCM 2499, Escherichia coli PCM 2793, Salmonella enteritidis PCM 2548, Micrococcus luteus PCM 525, and Proteus mirabilis PCM 1361. The metabolic activity of LAB was described by the Gompertz model, and the parameters proposed for this experiment were the maximum rate of change of electrical impedance and potential biodegradability. Antibacterial activity was examined using the culture method in a liquid medium, determination of the reduction in indicator microorganisms, and optical density changes. Results show that the selective LAB produced certain active biomolecules with antibacterial activity from whey, a by-product that is sometimes troublesome for goat milk processors to manage. Lactobacillus acidophilus is a microorganism that is characterized by the highest metabolic activity in goat milk and whey from goat milk. It has the possibility to produce macromolecules with antibacterial activity.

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Antifungal activity of lactic acid bacteria of Lactobacillus genus

Cited by 5 publications

References 58 publications

Antifungal Activity of Lactobacillus pentosus ŁOCK 0979 in the Presence of Polyols and Galactosyl-Polyols

Antifungal Activity of Lactobacillus pentosus ŁOCK 0979 in the Presence of Polyols and Galactosyl-Polyols

Candidacidal Activity of Xylitol and Sorbitol

The Evaluation of Activity of Selected Lactic Acid Bacteria for Bioconversion of Milk and Whey from Goat Milk to Release Biomolecules with Antibacterial Activity

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