Antifungal activity of medicinal plant extracts; preliminary screening studies

Webster, Duncan; Taschereau, P. M.; Belland, René J.; Sand, Crystal; Rennie, Robert

doi:10.1016/j.jep.2007.09.014

Cited by 156 publications

(128 citation statements)

References 16 publications

(24 reference statements)

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“…This higher antifungal activity might be related with the solubility of the active principles in the solvents used; phenolic compounds are one of the most abundant bioactive molecules present in those polar extracts. (Webster et al, 2008) C. krusei 12.5 mg/mL C. lusitaniae 12.5 mg/mL C. parapsilosis 12.5 mg/mL Adiantum capillus veneris C. albicans 1 mg/mL * (Ishaq et al, 2014) Allium sativum C. albicans 0.2 mg/mL (Shamim et al, 2004) 100 mg/mL * (Fei et al, 2008) 1 mg/mL * (Pathak, 2012) C. dublinensis 1 mg/mL * (Pathak, 2012) C. grabrata 0.2 mg/mL (Shamim et al, 2004) 1 mg/mL * (Pathak, 2012) C. krusei 100 mg/mL * (Fei et al, 2008) 1 mg/mL * (Pathak, 2012) C. tropicalis 0.2 mg/mL (Shamim et al, 2004) 100 mg/mL * (Fei et al, 2008) 1 mg/mL * (Pathak, 2012) Alnus viridis C. albicans 12.5 mg/mL (Webster et al, 2008) C. glabrata 25 mg/mL C. krusei 0.2 mg/mL C. lusitaniae 6 mg/mL C. parapsilosis 25 mg/mL C. tropicalis 3 mg/mL (Jasim and Al-khaliq, 2011) C. parapsilosis 2.5 mg/mL (Martins et al, 2015) C. tropicalis 1.25 mg/mL (Martins et al, 2015) Sapindus saponaria C. parapsilosis 0.16 mg/mL (Tsuzuki et al, 2007) Scutellaria baicalensis C. albicans 2.5 mg/mL (Wong and Tsang, 2009) C. glabrata 6.25 mg/mL C. guilliermondii 3.12 mg/mL C. krusei 3.12 mg/mL C. lusitaniae 1.56 mg/mL C. parapsilosis 3.12 mg/mL C. tropicalis 3.12 mg/mL * Dichloromethane extracts. MIC -Minimum inhibitory concentration.…”

Section: Discussionmentioning

confidence: 99%

Activity of phenolic compounds from plant origin against Candida species

Martins

Barros

Henriques

et al. 2015

Industrial Crops and Products

118

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Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival.Ergosterol, nucleic acids and glucan are the most studied molecular targets to destroy Candida species, being considered the basis of the development of new antifungal drugs. However, increasing levels of resistant Candida species to the current antifungal drugs have been observed, making ineffective those agents. Thus, other therapies more effective and safer than the current ones, are being studied, namely the use plant of extracts enriched in phenolic compounds. In this sense, this manuscript provide an historical perspective of the opportunistic fungal infections, molecular targets of the current anti-Candida drugs, as well as a general description of the active principles present in plants, focused on the antifungal potential of whole plant extracts and isolated phenolic compounds, against Candida species.

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Section: Discussionmentioning

confidence: 99%

Activity of phenolic compounds from plant origin against Candida species

Martins

Barros

Henriques

et al. 2015

Industrial Crops and Products

118

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“…The MIC of crude extracts is rarely found to be < 0.1 mg/ml but with more refined fractions or solitary compounds, MICs of < 0.1mg/ml may be suggestive of good antimicrobial activity and thus can be considered worthy for further investigations [9].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Properties of Marine Sponges from Mauritius Waters

Govinden-Soulange¹,

Marie²,

Kauroo³

et al. 2014

Trop. J. Pharm Res

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“…Fusarium genus is widely distributed in the soil, its representatives -necrotrophs are plant pathogens, most of which cause a series of plant diseases (Webster et al, 2008). Among the studied preparations, Biojodis was the most efficient in reducing the amount of Fusarium genus fungi on seeds, its biological efficiency comprised 81.8%.…”

Section: Resultsmentioning

confidence: 96%

Effect of biopreparations on seed germination and fungal contamination of winter wheat

Pekarskas¹,

Sinkevičienė²

2015

biologija

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The aim of the study was to investigate the influence of different biopreparations on the germination energy, germination and fungal infection of ecological winter wheat seeds.Germination energy and germination of winter wheat seeds were determined after 24, 480 and 960 h, while fungal infection after 24 and 960 h of their treatment. In the studies biopreparations Biokal 1 (10 l t -1 ), Biokal 2 (10 l t -1 ), Biojodis (2 l t -1 ) and Penergetic-p for roots (100 ml t -1 ) were used. It was found that the values of germination energy and germination of winter wheat treated with the biopreparations after 480 h increased by 4.45 and 0.62%, as compared to treated seeds after 24 h. After 960 h of treatment the value of germination energy, as compared to seeds treated after 480 h, decreased insignificantly, while the germination of seeds has reliably decreased by 0.84%, as compared to treated seeds after 24 h, the value of germination energy was by 3.45% higher, but no significant decrease in germination was ascertained.Biojodis after 24 h of the treatment was the most reliable in reducing wheat infection with the fungi of Fusarium, Alternaria, while Biokal 1 with Penicillium genera. The studied biopreparations after 960 h were insufficiently effective or had no influence at all on the development and spreading of fungi.The diseases of coleoptiles and roots of winter wheat after 24 h and 960 h were most reliably prevented by the biopreparation Biokal 2.

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Antifungal activity of medicinal plant extracts; preliminary screening studies

Cited by 156 publications

References 16 publications

Activity of phenolic compounds from plant origin against Candida species

Activity of phenolic compounds from plant origin against Candida species

Antibacterial Properties of Marine Sponges from Mauritius Waters

Effect of biopreparations on seed germination and fungal contamination of winter wheat

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